Generic name: trospium [ tros-PEE-um ]
Brand names: Sanctura XR, Regurin, Sanctura
Dosage forms: oral capsule, extended release (60 mg), oral tablet (20 mg)
Drug class: Urinary antispasmodics

Medically reviewed by Drugs.com on Aug 8, 2023. Written by Cerner Multum.

What is trospium?

Trospium relieves spasms of the bladder.

Trospium is used to treat overactive bladder and symptoms of urinary incontinence, frequency, and urgency.

Trospium may also be used for purposes not listed in this medication guide.

Trospium side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using trospium and call your doctor at once if you have a serious side effect such as:

• severe stomach pain or bloating;

• severe constipation;

• urinating less than usual or not at all; or

• confusion, hallucinations.

Less serious side effects may include:

• dry mouth or throat;

• headache;

• mild constipation;

• upset stomach, gas;

• dizziness, drowsiness, or

• dry eyes.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings

You should not take trospium if you are allergic to trospium, or if you have untreated or uncontrolled narrow-angle glaucoma, a blockage in your digestive system, or if you are unable to urinate.

Take trospium on an empty stomach, at least 1 hour before a meal.

Avoid drinking alcohol within 2 hours before or after you take trospium. Drinking alcohol can increase certain side effects of trospium.

This medication may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Trospium can decrease sweating, which makes it easier for you to have heat stroke. Drink plenty of fluids while you are taking this medication.

Before using trospium, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by trospium.

Before taking this medicine

You should not use trospium if you are allergic to it, or if you have:

• untreated or uncontrolled narrow-angle glaucoma;

• a blockage in your digestive system; or

• if you are unable to urinate.

To make sure you can safely take trospium, tell your doctor if you have any of these other conditions:

• glaucoma;

• liver disease;

• kidney disease;

• a stomach or intestinal disorder such as ulcerative colitis;

• a muscle disorder such as myasthenia gravis; or

• an enlarged prostate.

FDA pregnancy category C. It is not known whether trospium will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether trospium passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Older adults may be more likely to have side effects from this medicine.

How should I take trospium?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Take trospium on an empty stomach, at least 1 hour before a meal. Extended-release trospium (Sanctura XR) should be taken once each morning, at least 1 hour before a meal.

Do not crush, chew, break, or open an extended-release capsule. Swallow it whole. Breaking or opening the pill may cause too much of the drug to be released at one time.

Store at room temperature away from moisture and heat.

Trospium dosing information

Usual Adult Dose for Urinary Incontinence:

Immediate-release formulation:
20 mg orally 2 times a day

Extended-release formulation:
60 mg orally once a day in the morning

Use: for overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency

Usual Adult Dose for Urinary Frequency:

Immediate-release formulation:
20 mg orally 2 times a day

Extended-release formulation:
60 mg orally once a day in the morning

Use: for overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency

Usual Geriatric Dose for Urinary Incontinence:

Immediate-release formulation:
75 years and older:
20 mg orally once a day based on tolerability

Extended-release formulation:
60 mg orally once a day in the morning

Use: for overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency

Usual Geriatric Dose for Urinary Frequency:

Immediate-release formulation:
75 years and older:
20 mg orally once a day based on tolerability

Extended-release formulation:
60 mg orally once a day in the morning

Use: for overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency

What happens if I miss a dose?

Take the missed dose 1 hour before your next meal. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe forms of some of the side effects listed in this medication guide.

What should I avoid while taking trospium?

This medication may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

Avoid drinking alcohol within 2 hours before or after you take trospium. Drinking alcohol can increase certain side effects of trospium.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Trospium can decrease sweating, which makes it easier for you to have heat stroke. Drink plenty of fluids while you are taking this medication.

What other drugs will affect trospium?

Before using trospium, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by trospium.

Tell your doctor about all other medicines you use, especially:

• atropine (Atreza, Sal-Tropine, and others);

• belladonna (Donnatal, and others);

• benztropine (Cogentin);

• dimenhydrinate (Dramamine);

• metformin (Actoplus Met, Avandamet, Glucophage, Glucovance, Janumet, Kombiglyze, Metaglip, PrandiMet);

• morphine (Kadian, MS Contin, Oramorph);

• procainamide (Procanbid, Pronestyl);

• tenofovir (Viread);

• vancomycin (Vancocin);

• bronchodilators such as ipratropium (Atrovent) or tiotropium (Spiriva);

• bladder or urinary medications such as darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), tolterodine (Detrol), or solifenacin (Vesicare);

• irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Hyomax), or propantheline (Pro Banthine); or

• ulcer medications such as glycopyrrolate (Robinul) or mepenzolate (Cantil).

This list is not complete and other drugs may interact with trospium. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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