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Procainamide (injection)

Generic name: procainamide (injection) [ proe-KANE-a-mide ]
Brand names: Pronestyl, Procan SR, Pronestyl-SR, Procanbid
Dosage form: injectable solution (100 mg/mL; 500 mg/mL)
Drug class: Group I antiarrhythmics

Medically reviewed by on Sep 4, 2023. Written by Cerner Multum.

What is procainamide injection?

Procainamide is used to help keep the heart beating normally in people with certain heart rhythm disorders of the ventricles (the lower chambers of the heart that allow blood to flow out of the heart).

Procainamide may also be used for purposes not listed in this medication guide.

Procainamide injection side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your medical caregivers right away if you have:

Common side effects of procainamide may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Procainamide can cause serious side effects and is for use only to treat life-threatening heart rhythm problems. If you receive procainamide during an emergency, make sure any follow-up doctor knows you received procainamide.

Before taking this medicine

You may not be able to receive procainamide if:

If possible during an emergency, tell your medical caregivers if you've ever had:

It is not known if procainamide will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Do not breastfeed.

How is procainamide injection given?

Procainamide is injected into a muscle or vein by a healthcare provider.

Your heart function, blood pressure, and other vital signs will be watched closely.

You may get infections more easily, even serious or fatal infections. You may need medical tests for a short time after you receive procainamide injection.

What happens if I miss a dose?

In a medical setting you are not likely to miss a dose.

What happens if I overdose?

In a medical setting an overdose would be treated quickly.

What should I avoid while receiving procainamide injection?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

What other drugs will affect procainamide injection?

Tell your doctor about all other medicines you use, especially:

This list is not complete. Other drugs may affect procainamide, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I find more information?

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.