Generic Name: mexiletine (mex IL e teen)
Brand Name: Mexitil
What is mexiletine?
Mexiletine affects the way that your heart beats.
Mexiletine is used to treat seriously irregular heartbeats.
Mexiletine may also be used for purposes not listed in this medication guide.
You should not use mexiletine if you have a serious heart condition such as "AV block" (unless you have a pacemaker).
Before taking this medicine
You should not use mexiletine if you are allergic to it, or if you have:
a serious heart condition such as "AV block" (unless you have a pacemaker).
To make sure mexiletine is safe for you, tell your doctor if you have:
congestive heart failure;
epilepsy or other seizure disorder;
a weak immune system (caused by disease or by using certain medicine); or
FDA pregnancy category C. It is not known whether mexiletine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.
Mexiletine can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.
How should I take mexiletine?
Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Mexiletine is usually given at first in a hospital.
Take mexiletine with food or an antacid to lessen stomach upset.
Your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG).
Do not skip doses, change your dosing schedule, or stop taking mexiletine without talking to your doctor. Changing your schedule could make your condition much worse.
Store at room temperature away from moisture, heat, and light.
What happens if I miss a dose?
Try not to miss any doses of this medication. Missing doses could be very dangerous.
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking mexiletine?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Mexiletine side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Mexiletine may cause you to have abnormal liver function tests, especially if you also have congestive heart failure, or blood circulation problems.
Call your doctor at once if you have:
a new or a worsening irregular heartbeat pattern; or
liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Common side effects may include:
dizziness, feeling lightheaded;
tremors, feeling nervous;
problems with coordination; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
Mexiletine dosing information
Usual Adult Dose for Ventricular Tachycardia:
Initial dose: 200 mg orally every 8 hours when rapid control of arrhythmia is not essential.
A minimum of 2-3 days between dose adjustments is recommended.
Dose may be adjusted in 50 or 100 mg increments up or down.
Usual Pediatric Dose for Arrhythmias:
1.4 to 5 mg/kg/dose given every 8 hours. Begin with lower initial dosages and titrate to desired effects and serum concentrations.
What other drugs will affect mexiletine?
Other drugs may interact with mexiletine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
More about mexiletine
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Español
- 6 Reviews – Add your own review/rating
- Drug class: group I antiarrhythmics
Other brands: Mexitil
Related treatment guides
Where can I get more information?
- Your pharmacist can provide more information about mexiletine.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 5.01.
Last reviewed: November 10, 2014
Date modified: March 06, 2018