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Medications for Diabetic Peripheral Neuropathy

Other names: Diabetic Nerve Damage; DPN

About Diabetic Peripheral Neuropathy:  A common complication of diabetes mellitus in which nerves are damaged as a result of hyperglycemia (high blood sugar levels).

Drugs Used to Treat Diabetic Peripheral Neuropathy

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Popularity
gabapentin Off Label C N X 39 reviews
6.0

Generic name: gabapentin systemic

Drug class: gamma-aminobutyric acid analogs

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

Lyrica C 5 X 56 reviews
6.0

Generic name: pregabalin systemic

Drug class: gamma-aminobutyric acid analogs

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Cymbalta C N X 34 reviews
6.0

Generic name: duloxetine systemic

Drug class: serotonin-norepinephrine reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Topamax Off Label D N X 4 reviews
9.0

Generic name: topiramate systemic

Drug class: carbonic anhydrase inhibitor anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Off Label: Yes

Nucynta ER C 2 X 8 reviews
8.0

Generic name: tapentadol systemic

Drug class: narcotic analgesics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

pregabalin C 5 X 58 reviews
6.0

Generic name: pregabalin systemic

Brand names:  Lyrica, Lyrica CR

Drug class: gamma-aminobutyric acid analogs

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph

duloxetine C N X 37 reviews
6.0

Generic name: duloxetine systemic

Brand names:  Cymbalta, Irenka

Drug class: serotonin-norepinephrine reuptake inhibitors

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

tapentadol C 2 X 8 reviews
8.0

Generic name: tapentadol systemic

Brand name:  Nucynta ER

Drug class: narcotic analgesics

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph

topiramate Off Label D N X 9 reviews
6.0

Generic name: topiramate systemic

Brand names:  Topamax, Topamax Sprinkle, Topiragen

Drug class: carbonic anhydrase inhibitor anticonvulsants

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

capsaicin B N 7 reviews
4.0

Generic name: capsaicin topical

Brand names:  Zostrix Diabetic Foot Pain, Capsicum Oleoresin, Capzasin, Axsain, Capsin, Salonpas Pain Patch with Capsaicin, Zostrix, Capzasin-HP, Capzasin-P, Icy Hot PM Patch, Menthac Arthritis Cream with Capsaicin, Salonpas Gel-Patch, Sloan's Liniment, Trixaicin, Trixaicin HP, Capzasin Back and Body, Castiva Warming, Zostrix Sports …show all

Drug class: miscellaneous topical agents

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts

nortriptyline Off Label N N X 3 reviews
4.0

Generic name: nortriptyline systemic

Drug class: tricyclic antidepressants

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

carbamazepine Off Label D N X Add review
7.0

Generic name: carbamazepine systemic

Drug class: dibenzazepine anticonvulsants

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

Zostrix Diabetic Foot Pain B N 1 review
1.0

Generic name: capsaicin topical

Drug class: miscellaneous topical agents

For consumers: dosage, interactions, side effects

Capsicum Oleoresin B N Add review Rate

Generic name: capsaicin topical

Drug class: miscellaneous topical agents

For consumers: dosage, interactions, side effects

Capzasin B N Add review Rate

Generic name: capsaicin topical

Drug class: miscellaneous topical agents

For consumers: dosage, interactions, side effects

Axsain B N Add review Rate

Generic name: capsaicin topical

Drug class: miscellaneous topical agents

For consumers: dosage, interactions, side effects

Capsin B N Add review Rate

Generic name: capsaicin topical

Drug class: miscellaneous topical agents

For consumers: dosage, interactions, side effects

Irenka C N X Add review Rate

Generic name: duloxetine systemic

Drug class: serotonin-norepinephrine reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

mexiletine Off Label C N 1 review
8.0

Generic name: mexiletine systemic

Drug class: group I antiarrhythmics

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

Salonpas Pain Patch with Capsaicin B N Add review Rate

Generic name: capsaicin topical

Drug class: miscellaneous topical agents

For consumers: dosage, interactions, side effects

Topamax Sprinkle Off Label D N X Add review Rate

Generic name: topiramate systemic

Drug class: carbonic anhydrase inhibitor anticonvulsants

For consumers: dosage, interactions, side effects

Off Label: Yes

Topiragen Off Label D N X Add review Rate

Generic name: topiramate systemic

Drug class: carbonic anhydrase inhibitor anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Off Label: Yes

Zostrix B N 3 reviews
5.0

Generic name: capsaicin topical

Drug class: miscellaneous topical agents

For consumers: dosage, interactions, side effects

Capzasin-HP B N 1 review
1.0

Generic name: capsaicin topical

Drug class: miscellaneous topical agents

For consumers: dosage, interactions, side effects

Capzasin-P B N Add review Rate

Generic name: capsaicin topical

Drug class: miscellaneous topical agents

For consumers: dosage, interactions, side effects

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Alternative treatments for Diabetic Peripheral Neuropathy

The following products are considered to be alternative treatments or natural remedies for Diabetic Peripheral Neuropathy. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However there may be historical, cultural or anecdotal evidence linking their use to the treatment of Diabetic Peripheral Neuropathy.

  • Evening primrose

Learn more about Diabetic Peripheral Neuropathy

Micromedex® Care Notes

Drugs.com Health Center

Legend

Off Label This medication may not be approved by the FDA for the treatment of this condition.
Prescription Only / Over the Counter
Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Pregnancy
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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