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Medications for Diabetic Peripheral Neuropathy

Other names: Diabetic Nerve Damage; DPN

About Diabetic Peripheral Neuropathy

A common complication of diabetes mellitus in which nerves are damaged as a result of hyperglycemia (high blood sugar levels).

Drugs used to treat Diabetic Peripheral Neuropathy

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
gabapentin Off-label 6.2 50 reviews
Rx C N X

Generic name: gabapentin systemic

Drug class: gamma-aminobutyric acid analogs

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off-label: Yes

Lyrica 6.3 65 reviews
Rx C 5 X

Generic name: pregabalin systemic

Drug class: gamma-aminobutyric acid analogs

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Topamax Off-label 9.0 7 reviews
Rx D N X

Generic name: topiramate systemic

Drug class: carbonic anhydrase inhibitor anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Off-label: Yes

Cymbalta 6.3 40 reviews
Rx C N X

Generic name: duloxetine systemic

Drug class: serotonin-norepinephrine reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Nucynta ER 8.1 8 reviews
Rx C 2 X

Generic name: tapentadol systemic

Drug class: narcotic analgesics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

pregabalin 6.2 69 reviews
Rx C 5 X

Generic name: pregabalin systemic

Brand names:  Lyrica, Lyrica CR

Drug class: gamma-aminobutyric acid analogs

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

duloxetine 6.0 44 reviews
Rx C N X

Generic name: duloxetine systemic

Brand names:  Cymbalta, Irenka

Drug class: serotonin-norepinephrine reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

tapentadol 8.2 9 reviews
Rx C 2 X

Generic name: tapentadol systemic

Brand name:  Nucynta ER

Drug class: narcotic analgesics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

topiramate Off-label 7.4 13 reviews
Rx D N X

Generic name: topiramate systemic

Brand name:  Topamax

Drug class: carbonic anhydrase inhibitor anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off-label: Yes

capsaicin 4.9 9 reviews
Rx/OTC B N

Generic name: capsaicin topical

Brand names:  Zostrix, Capsin, Capzasin-HP, Sloan's Liniment, Castiva Warming, Menthac Arthritis Cream with Capsaicin, Qutenza …show all

Drug class: miscellaneous topical agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts

nortriptyline Off-label 5.0 5 reviews
Rx N N X

Generic name: nortriptyline systemic

Drug class: tricyclic antidepressants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off-label: Yes

carbamazepine Off-label Rate Add review
Rx D N X

Generic name: carbamazepine systemic

Drug class: dibenzazepine anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off-label: Yes

mexiletine Off-label 8.0 1 review
Rx C N

Generic name: mexiletine systemic

Drug class: group I antiarrhythmics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off-label: Yes

Irenka Rate Add review
Rx C N X

Generic name: duloxetine systemic

Drug class: serotonin-norepinephrine reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Zostrix 5.5 3 reviews
Rx/OTC B N

Generic name: capsaicin topical

Drug class: miscellaneous topical agents

For consumers: dosage, interactions, side effects

Capsin Rate Add review
Rx/OTC B N

Generic name: capsaicin topical

Drug class: miscellaneous topical agents

For consumers: dosage, interactions, side effects

Lyrica CR Rate Add review
Rx C 5 X

Generic name: pregabalin systemic

Drug class: gamma-aminobutyric acid analogs

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Capzasin-HP 1.0 2 reviews
Rx/OTC B N

Generic name: capsaicin topical

Drug class: miscellaneous topical agents

For consumers: dosage, interactions, side effects

Sloan's Liniment Rate Add review
Rx/OTC B N

Generic name: capsaicin topical

Drug class: miscellaneous topical agents

For consumers: dosage, interactions, side effects

Castiva Warming Rate Add review
Rx/OTC B N

Generic name: capsaicin topical

Drug class: miscellaneous topical agents

For consumers: dosage, interactions, side effects

Menthac Arthritis Cream with Capsaicin Rate Add review
Rx/OTC B N

Generic name: capsaicin topical

Drug class: miscellaneous topical agents

For consumers: dosage, interactions, side effects

Qutenza Rate Add review
Rx B N

Generic name: capsaicin topical

Drug class: miscellaneous topical agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Alternative treatments for Diabetic Peripheral Neuropathy

The following products are considered to be alternative treatments or natural remedies for Diabetic Peripheral Neuropathy. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However there may be historical, cultural or anecdotal evidence linking their use to the treatment of Diabetic Peripheral Neuropathy.

  • Evening primrose

Learn more about Diabetic Peripheral Neuropathy

IBM Watson Micromedex

Drugs.com Health Center

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription Only.
OTC Over the Counter.
Rx/OTC Prescription or Over the Counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.