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How long does it take for Lyrica to work?

Medically reviewed by Leigh Ann Anderson, PharmD. Last updated on May 15, 2024.

Official answer


Key Points

  • In clinical studies with Lyrica (pregabalin) some patients experienced a decrease in pain as early as the first week, which persisted during the entire study period.
  • These studies looked at fibromyalgia, diabetic nerve pain, spinal cord injury nerve pain, and pain after shingles. The length of the studies ranged from 5 weeks to 13 weeks long.
  • Your results may vary. Lyrica begins working right away but for some people it may take several weeks to feel the pain-relieving effects from Lyrica.

If you are not feeling the pain relief you expect, contact your doctor, who may need to adjust your dose or reassess your pain level.

Related questions

Can you take Lyrica long-term?

You should take Lyrica every day as prescribed by your doctor. Many people will take Lyrica long-term to help control their pain or seizures.

Don’t stop taking Lyrica without talking to your doctor first. If you need to stop taking Lyrica, your doctor will slowly discontinue it over a period of time, usually at least one week.

Abruptly stopping Lyrica may lead to side effects such as headaches, diarrhea, nausea, anxiety, problems with sleep, and increased sweating. If you take Lyrica for epilepsy and suddenly stop your medicine, your seizures may occur more often.

This is not all the information you need to know about Lyrica for safe and effective use. Review the full Lyrica (pregabalin) information here, and discuss this information and any questions with your doctor or other health care provider.


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