Generic Name: pregabalin (pre GAB a lin)
Brand Names: Lyrica
What is Lyrica?
Lyrica (pregabalin) is an anti-epileptic drug, also called an anticonvulsant. It works by slowing down impulses in the brain that cause seizures. Pregabalin also affects chemicals in the brain that send pain signals across the nervous system.
Lyrica is used to control seizures and to treat fibromyalgia. It is also used to treat pain caused by nerve damage in people with diabetes (diabetic neuropathy), herpes zoster (post-herpetic neuralgia), or spinal cord injury.
Lyrica may also be used for purposes not listed in this medication guide.
Lyrica can cause a severe allergic reaction. Stop taking this medicine and seek emergency medical help if you have hives or blisters on your skin, trouble breathing, or swelling in your face, mouth, or throat.
Some people have thoughts about suicide while taking Lyrica. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.
If you have diabetes or heart problems, call your doctor if you have weight gain or swelling in your hands or feet while taking this medicine.
If you are taking pregabalin to prevent seizures, keep taking the medication even if you feel fine.
Do not stop using Lyrica suddenly, even if you feel fine. Stopping suddenly may cause withdrawal symptoms.
Do not change your dose without your doctor's advice. Tell your doctor if the medication does not seem to work as well in treating your condition.
Before taking this medicine
You should not use Lyrica if you are allergic to pregabalin.
To make sure this medicine is safe for you, tell your doctor if you have ever had:
a mood disorder, depression, or suicidal thoughts;
heart problems (especially congestive heart failure);
a bleeding disorder;
low levels of platelets in your blood;
kidney disease (or if you are on dialysis);
diabetes (unless you are taking Lyrica to treat diabetic neuropathy);
drug or alcohol addiction; or
a severe allergic reaction (angioedema).
Some people have thoughts about suicide while taking Lyrica. Your doctor will need to check your progress at regular visits while you are using topiramate. Your family or other caregivers should also be alert to changes in your mood or symptoms.
Follow your doctor's instructions about taking seizure medication if you are pregnant. Seizure control is very important during pregnancy, and having a seizure could harm both mother and baby. Do not start or stop taking this medicine without your doctor's advice, and tell your doctor right away if you become pregnant.
If you are pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of Lyrica on the baby.
This medication can decrease sperm count and may affect fertility in men (your ability to have children). In animal studies, pregabalin also caused birth defects in the offspring of males treated with this medicine. However, it is not known whether these effects would occur in humans. Ask your doctor about your risk.
It is not known whether pregabalin passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.
Lyrica is not approved for use by anyone younger than 18 years old.
How should I take Lyrica?
Take Lyrica exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Take the medicine at the same time each day, with or without food.
Do not crush, chew, or break a Lyrica CR extended-release tablet. Swallow the tablet whole.
Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.
Do not stop using Lyrica suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.
Call your doctor if your symptoms do not improve, or if they get worse.
Wear a medical alert tag or carry an ID card stating that you take Lyrica. Any medical care provider who treats you should know that you take seizure medication.
Store at room temperature away from moisture, light, and heat.
Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.
See also: Dosage Information (in more detail)
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking Lyrica?
Avoid drinking alcohol. It may increase certain side effects of Lyrica.
This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Lyrica side effects
Lyrica can cause a severe allergic reaction. Stop taking this medicine and get emergency medical help if you have: hives or blisters on your skin; difficult breathing; swelling of your face, lips, tongue, or throat.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, depression, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have:
skin sores (if you have diabetes);
swelling in your hands or feet, rapid weight gain (especially if you have diabetes or heart problems); or
unexplained muscle pain, tenderness, or weakness (especially if you also have fever, unusual tiredness, or dark colored urine).
If you have diabetes, tell your doctor right away if you have any new sores or other skin problems.
Common Lyrica side effects may include:
swelling, weight gain;
nausea, dry mouth; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Lyrica?
Taking Lyrica with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking a sleeping pill, narcotic (opioid) medication, muscle relaxer, or medicine for anxiety, depression, or seizures.
Tell your doctor about all your current medicines and any you start or stop using, especially:
oral diabetes medicine - pioglitazone, rosiglitazone; or
an ACE inhibitor - benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril, quinapril, ramipril, or trandolapril.
This list is not complete. Other drugs may interact with pregabalin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
More about Lyrica (pregabalin)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Compare Alternatives
- Support Group
- Pricing & Coupons
- En Español
- 688 Reviews – Add your own review/rating
- Drug class: gamma-aminobutyric acid analogs
Other brands: Lyrica CR
Related treatment guides
Where can I get more information?
- Your pharmacist can provide more information about Lyrica.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Lyrica only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2018 Cerner Multum, Inc. Version: 6.02.
Date modified: February 28, 2018
Last reviewed: January 17, 2018