Lyrica Patient Tips
How it works
Lyrica is a brand of pregabalin. Pregabalin binds to specific sites in nerve tissue which is thought to be the mechanism for its nerve-pain relieving and antiseizure properties.
Used in the treatment of nerve pain associated with diabetes, shingles infection, and spinal cord injury. Also used in the treatment of fibromyalgia and partial onset seizures.
If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:
- May cause dizziness, drowsiness, and affect your ability to drive or operate machinery. Avoid alcohol.
- May cause edema, particularly in the feet or hands. This fluid retention may be noticed as weight gain, although weight gain can occur independent of fluid retention.
- Other side effects include headache, tremor, abnormal thinking, dry mouth, constipation, blurred vision, lack of energy, changes in some laboratory test results, and ECG changes.
- Similar to other medicines used to treat seizures, Lyrica increases the risk of depression and suicidal thoughts.
- Avoid abrupt or rapid discontinuation as discontinuation symptoms (including insomnia, nausea, headache, anxiety, increased sweating and diarrhea) have been reported. Taper dosage down gradually on a doctor's advice over a minimum of one week.
Notes: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. For a complete list of all side effects, click here.
- May be taken with or without food.
- Do not stop abruptly; discontinue slowly over at least a week. Exception is if you notice any facial or neck swelling, shortness of breath, or a skin rash then discontinue Lyrica immediately and seek urgent medical advice.
- Do not drive or operate machinery if Lyrica makes your drowsy or impairs your judgement.
- Notify your doctor if vision changes occur, if you experience unusual muscle pain or weakness, or if you are unexpectedly gaining weight.
- If you are planning to father a child, be aware that an association between Lyrica and birth defects has been reported in some animal studies.
Response and Effectiveness
Peak concentrations occur within 1.5 hours and effects last for approximately eight hours. Full antiseizure or nerve-pain relieving effects may take several weeks to develop, although some people experience relief as early as the first week.
Lyrica (pregabalin) [package insert]. Revised 08/2014. Parke-Davis Div of Pfizer Inc. https://www.drugs.com/pro/lyrica.html Accessed 02/2016
More about Lyrica (pregabalin)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Español
- 641 Reviews – Add your own review/rating
- Drug class: gamma-aminobutyric acid analogs
Related treatment guides
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Lyrica only for the indication prescribed.
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