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Lyrica CR (pregabalin) Drug Interactions

A total of 657 drugs are known to interact with Lyrica CR (pregabalin).

  • 6 major drug interactions
  • 649 moderate drug interactions
  • 2 minor drug interactions

Show all medications in the database that may interact with Lyrica CR (pregabalin).

Check for interactions

Type in a drug name to check for interactions with Lyrica CR (pregabalin).

Most frequently checked interactions

View interaction reports for Lyrica CR (pregabalin) and the medicines listed below.

  • amlodipine (Norvasc)
  • atorvastatin (Lipitor)
  • baclofen (Lioresal, Gablofen, Lioresal Intrathecal, Kemstro)
  • ciprofloxacin (Cipro, Cipro I.V., Cipro XR, Cipro Cystitis Pack, Proquin XR)
  • clonazepam (Klonopin, Klonopin Wafer)
  • Cymbalta (duloxetine)
  • duloxetine (Cymbalta, Irenka)
  • finasteride (Proscar, Propecia)
  • gabapentin (Neurontin, Gralise, Gabarone, Fanatrex)
  • levothyroxine (Synthroid, Levoxyl, Tirosint, Eltroxin, Levothroid, Levothyrox, Euthyrox, Unithroid, Levo-T, Oroxine, L Thyroxine Roche, Eutroxsig, Novothyrox, Tirosint-Sol, Levotabs, Levotec, Evotrox)
  • lisinopril (Zestril, Prinivil, Qbrelis)
  • losartan (Cozaar)
  • omeprazole (Prilosec, Prilosec OTC, Zegerid (Original Formulation), Omesec)
  • oxycodone (OxyContin, Roxicodone, Xtampza ER, OxyIR, Oxaydo, Dazidox, Oxyfast, Oxecta, RoxyBond, Oxydose, Percolone, M-Oxy, ETH-Oxydose, Endocodone, Roxicodone Intensol)
  • ranitidine (Zantac, Zantac 150, Zantac 300, Zantac 75, Acid Reducer, Deprizine, Acid Relief, Zantac 25 mg EFFERdose, Berkley and Jensen Acid Reducer Maximum Strength, Zantac GELdose, Zantac 300 GELdose, Zantac EFFERdose, Acid Reducer Non-Prescription Strength, Zantac Injection, Sunmark Acid Reducer Maximum Strength, Zantac 150 EFFERdose, Acid Control 75, Taladine, Careone Acid Reducer, Equaline Heartburn Relief, Acid Control 150)
  • sertraline (Zoloft)
  • topiramate (Topamax, Trokendi XR, Qudexy XR, Topiragen, Topamax Sprinkle)
  • tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Ultram ER, Tramahexal, ConZip, Larapam SR, Ryzolt, Tramal SR, GenRx Tramadol, Tramahexal SR, Tramedo, Zydol, Zamadol, Zydol XL, Rybix ODT, Ultram ODT)
  • trazodone (Desyrel, Oleptro, Desyrel Dividose)
  • Vitamin D3 (cholecalciferol)

Lyrica CR (pregabalin) alcohol/food interactions

There is 1 alcohol/food interaction with Lyrica CR (pregabalin)

Lyrica CR (pregabalin) disease interactions

There are 5 disease interactions with Lyrica CR (pregabalin) which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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