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Topiramate Drug Interactions

A total of 637 drugs are known to interact with topiramate.

  • 361 major drug interactions
  • 267 moderate drug interactions
  • 9 minor drug interactions

Show all medications in the database that may interact with topiramate.

Check for interactions with topiramate

Type in a drug name and select a drug from the list.

Common medications checked in combination with topiramate

  • Abilify (aripiprazole)
  • Adderall (amphetamine / dextroamphetamine)
  • Advil (ibuprofen)
  • Ambien (zolpidem)
  • amitriptyline (Elavil, Endep, Vanatrip)
  • aspirin (Aspir 81, Ecotrin, Acetylsalicylic Acid, Aspirin Low Strength, Aspir-Low, Bayer Aspirin, Ecotrin Adult Low Strength, Ascriptin, Fasprin, Arthritis Pain, Low Dose ASA, Aspiritab, Bufferin, Durlaza, Aspirin Lite Coat, Aspirtab, Halfprin, Bayer Children's Aspirin, St. Joseph 81 mg Aspirin Enteric Safety-Coated, Easprin, Aspergum, Buffered Aspirin, Ascriptin Enteric, Acuprin 81, Miniprin, Bayer Aspirin Regimen, St. Joseph 81 mg Chewable Aspirin, Empirin, Ecotrin Maximum Strength, St. Joseph Aspirin, Ecpirin, Bayer Women's Aspirin With Calcium, Ascriptin Maximum Strength, Arthritis Foundation Pain Reliever, Bayer Aspirin with Heart Advantage, Aspi-Cor, Bufferin Low Dose, Medi-Seltzer, Sloprin, ZORprin, Bayer Aspirin Extra Strength Plus, Buffex, Entercote, Extra Strength Bayer, Genacote, Gennin-FC, Genprin, Litecoat Aspirin, Minitabs, Tri-Buffered Aspirin, Entaprin, Bufferin Arthritis Strength, Bufferin Extra Strength, Therapy Bayer, Stanback Analgesic, Norwich Aspirin, Zero-Order Release, YSP Aspirin, Migralex, Heartline, Bayer Advanced Aspirin, Buffasal)
  • Benadryl (diphenhydramine)
  • bupropion (Wellbutrin, Wellbutrin XL, Wellbutrin SR, Zyban, Buproban, Budeprion, Forfivo XL, Aplenzin, Budeprion SR, Budeprion XL)
  • citalopram (Celexa)
  • Control (phenylpropanolamine)
  • Cymbalta (duloxetine)
  • ethanol (Alcohol (contained in alcoholic beverages), Ethyl Alcohol, Alcohol 5% in Dextrose 5%, Alcohol And Dextrose Injections USP Hypertonic, Palcohol, Dehydrated Alcohol, Ablysinol)
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • gabapentin (Neurontin, Gralise, Gabarone, Fanatrex)
  • garcinia cambogia
  • ibuprofen (Advil, Motrin, IBU, Proprinal, Advil Liqui-Gels, Motrin IB, IBU-200, Nuprin, Children's Motrin, Motrin Migraine Pain, Advil Migraine, Caldolor, Ibuprofen PMR, Advil Children's, Addaprin, NeoProfen, Advil Infant's Concentrated Drops, A-G Profen, Motrin Childrens, Childrens Ibuprofen Berry, Ibu-6, Ibu-8, Motrin Infant Drops, Ibu-Tab, Rufen, Genpril, Haltran, Menadol, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, Advil Junior Strength, Midol Maximum Strength Cramp Formula, Actiprofen, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Motrin Junior Strength, Help I Have An Aching Body, Children's ElixSure IB, Cap-Profen, Motrin Pediatric, Advil Film-Coated)
  • Lexapro (escitalopram)
  • Lyrica (pregabalin)
  • metformin (Glucophage, Glumetza, Glucophage XR, Riomet, Fortamet)
  • methadone (Methadose, Dolophine, Methadone Diskets, Methadose Sugar-Free)
  • naproxen (Aleve, Naprosyn, Naproxen Sodium DS, Anaprox, Naprelan, Anaprox-DS, Flanax Pain Reliever, Leader Naproxen Sodium, EC-Naprosyn, Aflaxen, All Day Pain Relief, Comfort Pac with Naproxen, Pamprin All Day Relief, Midol Extended Relief, All Day Relief)
  • Nexium (esomeprazole)
  • Norco (acetaminophen / hydrocodone)
  • phentermine (Adipex-P, Lomaira, Fastin, Suprenza, Ionamin, Teramine, Obenix, Atti-Plex P, Pro-Fast HS, Phentercot, Oby-Cap, Phentride, Obephen, Panshape M, Pro-Fast SR, T-Diet, Zantryl, Oby-Trim, Pro-Fast SA, Teramine ER)
  • ProAir HFA (albuterol)
  • propranolol (Inderal, Inderal LA, InnoPran XL, Hemangeol, Inderal XL)
  • Seroquel (quetiapine)
  • Singulair (montelukast)
  • Synthroid (levothyroxine)
  • tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Tramedo, Ultram ER, Larapam SR, GenRx Tramadol, ConZip, Zydol, Ryzolt, Tramahexal, Zamadol, Tramal SR, Tramahexal SR, Zydol XL, Rybix ODT, Ultram ODT)
  • Tylenol (acetaminophen)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin C (ascorbic acid)
  • Vitamin D2 (ergocalciferol)
  • Vitamin D3 (cholecalciferol)
  • Wellbutrin (bupropion)
  • Xanax (alprazolam)
  • Zyrtec (cetirizine)

Topiramate alcohol/food interactions

There is 1 alcohol/food interaction with topiramate

Topiramate disease interactions

There are 9 disease interactions with topiramate which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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