Generic name: gabapentin (GA ba PEN tin)
Brand name: Gralise, Horizant, Neurontin, Gabarone
Drug class: Gamma-aminobutyric acid analogs
What is gabapentin?
Gabapentin is used together with other medicines to treat partial seizures in adults and children at least 3 years old.
Use only the brand and form of gabapentin your doctor has prescribed. Check your medicine each time you get a refill to make sure you receive the correct form.
The Gralise brand of gabapentin is indicated for the management of neuropathic pain only. It is not used for epilepsy.
Horizant is used to treat nerve pain and restless legs syndrome (RLS).
The Neurontin brand is used to treat seizures in adults and children who are at least 3 years old, in addition to neuropathic pain.
Gabapentin can cause life-threatening breathing problems, especially if you already have a breathing disorder or if you use other medicines that can make you drowsy or slow your breathing. Seek emergency medical attention if you have very slow breathing.
Some people have thoughts about suicide or behavior changes while taking gabapentin. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.
Avoid driving or hazardous activity until you know how gabapentin will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.
Do not stop using gabapentin suddenly, even if you feel fine.
Before taking this medicine
You should not use gabapentin if you are allergic to it.
To make sure gabapentin is safe for you, tell your doctor if you have ever had:
breathing problems or lung disease, such as chronic obstructive pulmonary disease (COPD);
kidney disease (or if you are on dialysis);
a seizure (unless you take gabapentin to treat seizures);
heart disease; or
(for patients with RLS) if you are a day sleeper or work a night shift.
Some people have thoughts about suicide while taking this medicine. Children taking gabapentin may have behavior changes. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Seizure control is very important during pregnancy, and having a seizure could harm both mother and baby. Do not start or stop taking gabapentin for seizures without your doctor's advice, and tell your doctor right away if you become pregnant.
If you are pregnant, your name may be listed on a pregnancy registry to track the effects of gabapentin on the baby.
It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.
How should I take gabapentin?
Take gabapentin exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take in larger or smaller amounts or for longer than recommended.
If your doctor changes your brand, strength, or type of gabapentin, your dosage needs may change. Ask your pharmacist if you have any questions about the new kind of gabapentin you receive at the pharmacy.
Both Gralise and Horizant should be taken with food.
Neurontin can be taken with or without food.
If you break a Neurontin tablet and take only half of it, take the other half at your next dose. Any tablet that has been broken should be used as soon as possible or within a few days.
Swallow the capsule or tablet whole and do not crush, chew, break, or open it.
Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).
Do not stop taking this medicine suddenly, even if you feel fine. Stopping suddenly may cause increased seizures. Follow your doctor's instructions about tapering your dose.
In case of emergency, wear or carry medical identification to let others know you have seizures.
This medicine can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using gabapentin.
Store both the tablets and capsules at room temperature away from light and moisture.
Store the liquid medicine in the refrigerator. Do not freeze.
Usual Adult Dose for Epilepsy:
Initial dose: 300 mg orally on day one, 300 mg orally 2 times day on day two, then 300 mg orally 3 times a day on day three
Maintenance dose: 300 to 600 mg orally 3 times a day
Maximum dose: 3600 mg orally daily (in 3 divided doses)
-Maximum time between doses in the 3 times a day schedule should not exceed 12 hours
-The safety and effectiveness of gabapentin available under the trade name Gralise or Horizant in patients with epilepsy has not been studied.
Use: Adjunctive therapy in the treatment of partial onset seizures, with and without secondary generalization
Usual Adult Dose for Postherpetic Neuralgia:
-Initial dose: 300 mg orally on day one, 300 mg orally 2 times day on day two, then 300 mg orally 3 times a day on day three
-Titrate up as needed for pain relief
-Maximum dose: 1800 mg per day (600 mg orally 3 times a day)
Gabapentin available under the trade name Gralise:
-Maintenance dose: Gralise should be titrated to 1800 mg orally once daily with the evening meal.
-Recommended titration schedule:
Day 1: 300 mg orally with the evening meal
Day 2: 600 mg orally with the evening meal
Days 3 through 6: 900 mg orally with the evening meal
Days 7 through 10: 1200 mg orally with the evening meal
Days 11 through 14: 1500 mg orally with the evening meal
Day 15: 1800 mg orally with the evening meal
-Gralise is not interchangeable with other gabapentin products because of differing pharmacokinetic profiles that affect the frequency of administration.
Gabapentin enacarbil extended release tablets are available under the trade name Horizant:
-The recommended dosage is 600 mg orally 2 times a day. Therapy should be initiated at a dose of 600 mg orally in the morning for 3 days of therapy, then increased to 600 mg 2 times a day (1200 mg/day) on day four.
Gabapentin enacarbil extended release tablets available under the trade name Horizant and gabapentin are not interchangeable.
Use: Postherpetic neuralgia
Usual Adult Dose for Restless Legs Syndrome:
Gabapentin enacarbil available under the trade name Horizant:
600 mg orally once daily with food at about 5 PM
Use: For the treatment of moderate-to-severe primary Restless Legs Syndrome (RLS) in adults
Usual Pediatric Dose for Epilepsy:
Less than 3 years: Not recommended
Greater than or equal to 3 and less than 12 years:
Starting Dose: Ranges from 10 to 15 mg/kg/day in 3 divided doses
Effective Dose: Reached by upward titration over a period of approximately 3 days; the effective dose in patients 5 years of age and older is 25 to 35 mg/kg/day in divided doses (3 times a day). The effective dose in pediatric patients ages 3 and 4 years is 40 mg/kg/day and given in divided doses (3 times a day). Gabapentin may be administered as the oral solution, capsule, or tablet, or using combinations of these formulations. Dosages up to 50 mg/kg/day have been well tolerated in a long term clinical study. The maximum time interval between doses should not exceed 12 hours.
Greater than 12 years:
-Initial dose: 300 mg orally on day one, 300 mg orally 2 times a day on day two, then 300 mg orally 3 times a day on day three
-Maintenance dose: 900 to 1800 mg orally in 3 divided doses; the dose may be increased up to 1800 mg/day. Dosages up to 2400 mg/day have been well tolerated in long term clinical studies. Doses of 3600 mg/day have also been administered to a small number of patients for a relatively short duration, and have been well tolerated. The maximum time between doses in the three times a day schedule should not exceed 12 hours.
Use: Adjunctive therapy in the treatment of partial onset seizures, with and without secondary generalization in patients 3 years of age and older
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
If you take Horizant: Skip the missed dose and use your next dose at the regular time. Do not use two doses of Horizant at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What to avoid
Avoid driving or hazardous activity until you know how gabapentin will affect you. Your reactions could be impaired. Dizziness or drowsiness can cause falls, accidents, or severe injuries.
Avoid taking an antacid within 2 hours before you take gabapentin. Antacids can make it harder for your body to absorb gabapentin.
Avoid drinking alcohol while taking gabapentin.
Gabapentin side effects
Get emergency medical help if you have signs of an allergic reaction to gabapentin: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, upper stomach pain, or yellowing of your skin or eyes.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), depressed, or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have:
weak or shallow breathing;
blue-colored skin, lips, fingers, and toes;
confusion, extreme drowsiness or weakness;
problems with balance or muscle movement;
unusual or involuntary eye movements; or
Gabapentin can cause life-threatening breathing problems. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up. Breathing problems may be more likely in older adults or in people with COPD.
Some side effects are more likely in children taking gabapentin. Contact your doctor if the child taking this medicine has any of the following side effects:
changes in behavior;
trouble concentrating; or
acting restless, hostile, or aggressive.
Common gabapentin side effects may include:
fever, chills, sore throat, body aches, unusual tiredness;
swelling of your legs and feet;
dizziness, drowsiness, tiredness;
problems with balance or eye movements; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect gabapentin?
Using gabapentin with other drugs that make you drowsy or slow your breathing can cause dangerous side effects or death. Ask your doctor before using opioid medication, a sleeping pill, cold or allergy medicine, a muscle relaxer, or medicine for anxiety or seizures.
other drugs may interact with gabapentin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Gabapentin is approved to treat the type of nerve pain (neuralgia) that results from nerve damage. Gabapentin is used to treat neuralgia caused by a herpes zoster viral infection, also known as shingles. This pain is called post-herpetic neuralgia (PHN), and it can be severe and chronic. Gabapentin is also used to treat pain from diabetic neuropathy, which happens when nerves in the feet damaged by diabetes cause chronic burning pain. Continue reading
Gabapentin may cause weight gain, but it is a rare side effect. Studies have shown that a small number of people taking gabapentin weight gain. People who do gain weight may gain about 5 pounds after 6 weeks of use. Continue reading
Case reports have shown that gabapentin withdrawal can last for up to 5 days or longer, but the duration has not been well established in human studies. The symptoms and how long they last depend on how much of the drug you are taking and for how long you’ve been taking it. Continue reading
Unless you have a side effect or reaction to gabapentin, it may not make you feel any different. Gabapentin is used to treat seizures, nerve pain and the symptoms of restless legs syndrome. If gabapentin works for you, you may feel relief from these symptoms. Continue reading
It can take several weeks for gabapentin to reach its full effect, but this depends on the condition being treated and your individual response to the drug. Continue reading
The anti-seizure medication gabapentin is not currently considered a narcotic or controlled substance by the federal government, but certain states have enacted legislation so that the medication is treated as one or monitored by the state’s prescription drug monitoring program. Continue reading
More about gabapentin
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Patient Tips
- Drug Images
- Drug Interactions
- Compare Alternatives
- Pricing & Coupons
- En Español
- 2272 Reviews
- Drug class: gamma-aminobutyric acid analogs
- Advanced Reading
- Gabapentin Capsules
- Gabapentin Oral Solution
- Gabapentin Tablets (PHN)
- Gabapentin Tablets 600 mg and 800 mg
Related treatment guides
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use gabapentin only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2022 Cerner Multum, Inc. Version: 17.01.