Capzasin-HP Side Effects
Generic Name: capsaicin topical
Note: This page contains information about the side effects of capsaicin topical. Some of the dosage forms included on this document may not apply to the brand name Capzasin-HP.
For the Consumer
Applies to capsaicin topical: topical cream, topical film, topical gel/jelly, topical liquid, topical lotion, topical ointment, topical pad, topical patch extended release, topical stick
In addition to its needed effects, some unwanted effects may be caused by capsaicin topical (the active ingredient contained in Capzasin-HP). In the event that any of these side effects do occur, they may require medical attention.
Major Side Effects
You should check with your doctor immediately if any of these side effects occur when taking capsaicin topical:More common - all forms
- Burning, itching, dryness, pain, redness, swelling, or soreness at the application site
- cough-producing mucus
- difficulty with breathing
- shortness of breath or troubled breathing
- sore throat
- stuffy or runny nose
- tightness in the chest or wheezing
- Blurred vision
- pounding in the ears
- slow or fast heartbeat
- Bloating or swelling of the face, arms, hands, lower legs, or feet
- increased sensitivity to pain
- increased sensitivity to touch
- rapid weight gain
- tingling in the hands and feet
- unsteadiness or awkwardness
- unusual weight gain or loss
- weakness in the arms, hands, legs, or feet
Minor Side Effects
Some of the side effects that can occur with capsaicin topical may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:Less common - patch only
- muscle aches
- pain or tenderness around the eyes and cheekbones
- unusual tiredness or weakness
- Abnormal skin color
- change in taste
- loss of taste
For Healthcare Professionals
Applies to capsaicin topical: compounding powder, topical cream, topical film, topical gel, topical kit, topical liquid, topical lotion, topical stick
The most commonly reported side effects were application site erythema and application site pain.[Ref]
Very common (10% or more): Application site erythema (63%), application site pain (42%)
Common (1% to 10%): Application site pruritus, application site papules, application site edema, application site swelling, application site dryness
Uncommon (0.1% to 1%): Application site urticaria, application site paresthesia, application site dermatitis, application site hyperesthesia, application site excoriation, application site warmth, application site anesthesia, application site bruising, application site inflammation, application site exfoliation[Ref]
Common (1% to 10%): Hypertension
Uncommon (0.1% to 1%): First degree atrio-ventricular (AV) block, tachycardia, palpitations, increased blood pressure[Ref]
Uncommon (0.1% to 1%): Herpes zoster, pruritus
Frequency not reported: Abnormal skin odor, second degree burns[Ref]
Common (1% to 10%): Nasopharyngitis, bronchitis, sinusitis
Uncommon (0.1% to 1%): Cough, throat irritation
Frequency not reported: Sneezing, dyspnea, wheezing, exacerbation of asthma, irritation of the mucous membranes of the respiratory tract (such as nasal and throat irritation)[Ref]
Common (1% to 10%): Nausea[Ref]
Uncommon (0.1% to 1%): Pain in extremity, muscle spasms[Ref]
Uncommon (0.1% to 1%): Dysgeusia, hypoesthesia, burning sensation
Frequency not reported: Headache, peripheral sensory neuropathy, dizziness, dysgeusia, hyperesthesia[Ref]
Uncommon (0.1% to 1%): Eye irritation
Frequency not reported: Irritation of the mucous membranes of the eyes, runny eyes[Ref]
Frequency not reported: Peripheral edema[Ref]
1. "Product Information. Zostrix-HP (capsaicin topical)." Medicis Pharmaceutical Corporation, Scottsdale, AZ.
2. "Product Information. Qutenza (capsaicin topical)." NeurogesX Inc, San Mateo, CA.
3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
4. "Product Information. Zostrix (capsaicin topical)." Southwood Pharmaceuticals Inc, Lake Forest, CA.
5. Cerner Multum, Inc. "Australian Product Information." O 0
6. "Product Information. Axsain (capsaicin topical)." Rodlen Laboratories, Vernon Hills, IL.
Not all side effects for Capzasin-HP may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
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