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Drizalma Sprinkle

Generic name: duloxetinedu-LOX-e-teen ]
Brand names: Cymbalta, Drizalma Sprinkle, Irenka
Drug class: Serotonin-norepinephrine reuptake inhibitors

Medically reviewed by on Nov 1, 2021. Written by Cerner Multum.

What is Drizalma Sprinkle?

Drizalma Sprinkle is a serotonin and norepinephrine reuptake inhibitor antidepressant (SNRI).

Drizalma Sprinkle is used to treat major depressive disorder in adults. This medicine is also used to treat general anxiety disorder in adults and children at least 7 years old.

Drizalma Sprinkle is also used in adults to treat diabetic nerve pain or chronic muscle or joint pain (such as low back pain and osteoarthritis pain).

Some brands of duloxetine are also used to treat fibromyalgia (a chronic pain disorder). Drizalma is for treating fibromyalgia only in adults. Cymbalta may be used to treat fibromyalgia in adults and children at least 13 years old.

Drizalma Sprinkle may also be used for purposes not listed in this medication guide.


People with depression or mental illness may have thoughts about suicide. Some young people may have increased suicidal thoughts when first starting a medicine to treat depression. Tell your doctor right away if you have any sudden changes in mood or behavior, or thoughts about suicide.

Do not stop using Drizalma Sprinkle without first asking your doctor.

Before taking this medicine

You should not use Drizalma Sprinkle if you are allergic to it.

Do not take Drizalma Sprinkle within 5 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine. A dangerous drug interaction could occur.

Tell your doctor if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. An interaction with Drizalma Sprinkle could cause a serious condition called serotonin syndrome.

Not approved for use by anyone younger than 7 years old.

Tell your doctor if you have ever had:

People with depression or mental illness may have thoughts about suicide. Some young people may have increased suicidal thoughts when first starting a medicine to treat depression. Stay alert to changes in your mood or symptoms. Your family or caregivers should also watch for sudden changes in your behavior.

Taking Drizalma Sprinkle during pregnancy could harm the baby, but stopping the medicine may not be safe for you. Do not start or stop Drizalma Sprinkle without asking your doctor.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of duloxetine on the baby.

If you are breastfeeding, tell your doctor if you notice drowsiness, feeding problems, and slow weight gain in the nursing baby.

How should I take Drizalma Sprinkle?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Taking Drizalma Sprinkle in higher doses or more often than prescribed will not make it more effective, and may increase side effects.

Swallow the capsule whole and do not crush, chew, break, or open it.

Take with or without food.

Your blood pressure will need to be checked often.

Tell your doctor if you have any changes in sexual function, such as loss of interest in sex, trouble having an orgasm, or (in men) problems with erections or ejaculation. Some sexual problems can be treated.

Your symptoms may not improve for up to 4 weeks.

Do not stop using Drizalma Sprinkle suddenly, or you could have unpleasant symptoms (such as agitation, confusion, tingling or electric shock feelings). Ask your doctor before stopping the medicine.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include vomiting, dizziness or drowsiness, seizures, fast heartbeats, fainting, or coma.

What should I avoid while taking Drizalma Sprinkle?

Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen, naproxen, Advil, Aleve, Motrin, and others. Using an NSAID with Drizalma Sprinkle may cause you to bruise or bleed easily.

Avoid driving or hazardous activity until you know how Drizalma Sprinkle will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Drinking alcohol may increase your risk of liver damage, especially if you take Drizalma.

Drizalma Sprinkle side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Tell your doctor right away if you have new or sudden changes in mood or behavior, including new or worse depression or anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, more active or talkative, or have thoughts about suicide or hurting yourself.

Drizalma Sprinkle may cause serious side effects. Call your doctor at once if you have:

  • pounding heartbeats or fluttering in your chest;

  • a light-headed feeling, like you might pass out;

  • easy bruising, unusual bleeding;

  • vision changes;

  • painful or difficult urination;

  • liver problems--right-sided upper stomach pain, itching, dark urine, jaundice (yellowing of the skin or eyes);

  • low blood sodium--headache, confusion, problems with thinking or memory, weakness, feeling unsteady; or

  • manic episodes--racing thoughts, increased energy, decreased need for sleep, risk-taking behavior, being agitated or talkative.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Common side effects of Drizalma Sprinkle may include:

  • drowsiness;

  • nausea, constipation, loss of appetite;

  • dry mouth; or

  • increased sweating.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Drizalma Sprinkle?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Many drugs can affect Drizalma Sprinkle. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all other medicines you use.

Popular FAQ

Not being able to sleep (also called insomnia) is one of the most common side effects reported by people taking Cymbalta. In some people, this side effect improves after a couple of weeks of taking Cymbalta, but difficulty falling asleep or staying asleep can persist in others. Here are some ways you can improve sleep while taking Cymbalta:

  • Take your dose of Cymbalta in the morning. Cymbalta may be given once a day or twice a day but for those people experiencing insomnia, it should be taken just once a day in the morning
  • Swallow Cymbalta capsules whole; do not crush, chew, or open up the capsules and sprinkle them on food because this may cause Cymbalta to be absorbed more quickly than intended, increasing the risk of side effects such as insomnia...
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It may take up to 6 to 8 weeks for the full effects of Cymbalta to be seen, although some improvement in symptoms, such as sleep, energy, or appetite may show an improvement in 1-2 weeks. Symptoms such as depressed mood and lack of interest in activities may take the full 6-8 weeks to resolve. When Cymbalta is used for pain, it generally improves within two weeks. Continue reading

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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.