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How long does it take for Cymbalta to work?

Medically reviewed by Carmen Pope, BPharm. Last updated on Jan 10, 2022.

Official answer


It may take up to 6 to 8 weeks for the full effects of Cymbalta to be seen, although some improvement in symptoms, such as sleep, energy, or appetite may show an improvement in 1-2 weeks. Symptoms such as depressed mood and lack of interest in activities may take the full 6-8 weeks to resolve. When Cymbalta is used for pain, it generally improves within two weeks.

Side effects such as include feeling sick, a dry mouth, headache, constipation, or feeling sleepy may occur early on, but these are usually mild and go away after a couple of weeks.

  • Duloxetine 31 January 2022.
  • Duloxetine (Cymbalta). NAMI.
  • Cymbalta (duloxetine) Updated 09/2021. Eli Lilly and Company.

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