Skip to Content

User Reviews for Milnacipran

Also known as: Savella

Milnacipran has an average rating of 6.7 out of 10 from a total of 345 ratings on 53% of those users who reviewed Milnacipran reported a positive effect, while 22% reported a negative effect.

Condition Avg. Rating Reviews Compare
Somatoform Pain Disorder  Off-label 10.0
2 reviews 12 medications
Reflex Sympathetic Dystrophy Syndrome  Off-label 7.0
4 reviews 2 medications
Fibromyalgia   6.7
339 reviews 20 medications
Summary of Milnacipran reviews 6.7 345 reviews

Reviews may be moderated or edited before publication to correct grammar and spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest in the medication will not be published. As reviews and ratings are subjective and self-reported, this information should not be used as the basis for any statistical analysis or scientific studies.

Reviews for Milnacipran

Masik · Taken for 2 to 5 years February 22, 2021

Savella (milnacipran) for Fibromyalgia: “This medication is life saver. Have been taking for 4 years 100 mg 2 times a day. Pain is gone. The only side effect I had is elevated pulse. Dr prescribed propranolol and no problems now. Highly recommend this medication. Give it 2 weeks to start working.”

10 / 10
zero stars · Taken for 10 years or more January 21, 2021

Savella (milnacipran) for Fibromyalgia: “I was prescribed Savella for chronic pain in 2009. I took it until 2020. It did not help pain at all. I experienced severe hot flashes my pain was worse taking it. Once I stopped taking Savella I felt immediate relief. I would not recommend Savella to my worst enemy. I think it aged my body and skin. I lost out on 10 years of life because I couldn't attend events with family or work. I'm now a 53 year old female. Savella to me was the biggest mistake of my life. I didn't taper off I stopped cold turkey with no issues. Run do not walk from this horrible drug.”

1 / 10
Anonymous · Taken for 5 to 10 years December 8, 2020

Savella (milnacipran) for Fibromyalgia: “Before I tried Savella nothing else helped my fibro pain. Savella is a miracle drug for me.”

10 / 10
DeeDee · Taken for 6 months to 1 year November 26, 2020

For Fibromyalgia: “I found that Joncia (another brand of milnacipran) helped my pain greatly. Unfortunately my heartbeat went up to 240 beats and my blood pressure also increased. I was admitted to hospital for another condition and the nurses though the blood pressure monitor was broken They ended up referring me to a cardiologist. Once I stopped taking the Joncia everything has returned to normal. I had an ablation but the side effects of the Joncia continued to effect my heart. I miss it for the pain relief but it was just too risky to continue taking it.”

3 / 10
Lizz · Taken for 2 to 5 years November 23, 2020

Savella (milnacipran) for Fibromyalgia: “Savella is the only thing that has helped my FM in years. I'm finally back at work and loving life. Can’t believe they have stopped making it.”

10 / 10
LeeAnn · Taken for 1 to 6 months November 22, 2020

Savella (milnacipran) for Fibromyalgia: “I was on Savella for Autoimmune diseases, it never helped me in any way. Never decreased my pain but it did give me awful headaches. Would not recommend.”

1 / 10
Mslovely41 · Taken for 1 to 6 months February 11, 2020

Savella (milnacipran) for Fibromyalgia: “I've been on Savella for a month now, I had nausea and headache for the first week but that stopped and then I noticed that my body isn't swollen anymore (my body has been constantly swollen for 12 years, never knowing why, it was my muscles inflamed) and my muscles aren't killing me to move. In 12 years I've had zero relief and this had given me some, unfortunately I've had to come down to half does because I am having heart issues... I already suffer from palpitations and it seems like my heart just isn't finding the normal rhythm anymore. I don't want to stop taking this as nothing has ever happens me and I'm loving not being swollen anymore and it's bliss to not have that severe muscle pain! Oh and those who want to scare people from taking this,.please stop.... We are all different when it comes to medication...”

5 / 10
Vanessa B · Taken for 6 months to 1 year January 30, 2020

Savella (milnacipran) for Fibromyalgia: “After an on the job accident in 2016, Every day was a struggle. I seriously did not want to exist. Any pain or injury I ever incurred in my life seemed to be radiating through my body every minute of every day. I started the meds and within the first 3 days I was weeping over the fact I felt alive again. I do sneeze every morning after taking the first one for the day. I take 50mg 2x a day. I also suffer from freezing feet and occasionally some nausea .I cannot exercise as 5 sit ups causes me to feel like I did 1000 and I pay dearly for it for days, so my course of treatment is no exercise except what I get in my everyday work and personal life. I understand the med isn’t going to work for everyone but even though it is so expensive, there is no price on the relief from the disease. I wish it was a little more affordable.”

10 / 10
Mickey · Taken for less than 1 month January 28, 2020

Savella (milnacipran) for Fibromyalgia: “Not sure how this Savella will work. first few days felt great then as each day passed started to feel worse with headaches and leg muscle pain. That's only 1 weeks of experience”

2 / 10
Severna January 11, 2020

Savella (milnacipran) for Fibromyalgia: “I have been using Savella for over 6 years for fibromyalgia and have had extremely good results. I have a absolutely no discernible side effects. It has taken me more than 10 years to finally get the right reuptake inhibitor and dosage correct. I went through years of trying first just pain meds like tramadol, buprenorphine patches etc, with poor results. I did Cymbalta for years (an SNRI) and got good relief from fibromyalgia, but it wiped out my sexual response. I finally found Savella and this has been the best. I have normal sexual response and everything else is normal.”

10 / 10
Elaine December 12, 2019

Savella (milnacipran) for Fibromyalgia: “This medication Savella did wonders for my fibromyalgia for the month I was on it. My muscle and joint pain disappeared and I had energy and could focus again! The caveat: it made me sweat profusely. Dripping sweat. It made me look like a drowned rat every day. My blood pressure also skyrocketed and I often felt my heart racing. So I have weaned off the medication and now I am in pain again. At least I'm, not worried I'll have a stroke and I don't look like a drowned rat anymore! On to try something else.”

9 / 10
Srudy · Taken for 5 to 10 years December 2, 2019

Savella (milnacipran) for Fibromyalgia: “Started taking this drug 8 years ago. The hot flashes and sweats were really bad at the beginning. Was told by my rheumatologist that I should push through. The good outweighed the bad for many years-it helped with my fibromyalgia pain, anxiety, adhd and ocd. But now I have had headaches more often, but recently noticed my blood pressure creeping up every time I go to the doctor. I’m vegan, and am pretty healthy so this is odd to me. Dr says it’s not the Savella but I think it is. GP wants to start me on BP meds-ugh. Should I stop the Savella or just keep taking it and add the BP meds?”

5 / 10
I don't like snow · Taken for less than 1 month November 12, 2019

Savella (milnacipran) for Fibromyalgia: “Well, I've only been taking Savella for a few days for my FM, but it's affecting me negatively. I'm so dizzy, I have no energy but my heart is racing. The side effects are too much for me.”

1 / 10
Fibromom August 8, 2019

Savella (milnacipran) for Fibromyalgia: “I was diagnosed with Fibro 10 years ago. Rheumatologist started me on flexeril, tramadol & Ambien. Never had an increase in meds and felt good. Then insurance changed and sent me to pain management. They were awful - so I got fed up and fired them - walked away. Here I am 2 years later, tons of pain and back to my rheumatologist I went. I am allergic to cymbalta and lyrica. Can’t take NSAIDS so he prescribed Gabapentin & Savella and flexeril. I am NEVER going to take GABA I have always said. Nevertheless starting that and Savella at the same time! I’m on day 4 of Savella and I’m always dizzy, nauseous (with or without food) - heart rate escalates, clump of hair fell out today and my vision is blurry and my restless legs are WORSE. My nights have been excruciating and I will NOT be taking it anymore. Has not helped me or given any relief (just grief) - for those of you who it helped, I’m happy your found something but it’s NOT for this gal.”

1 / 10
Dragonfly · Taken for 1 to 6 months July 8, 2019

Savella (milnacipran) for Fibromyalgia: “My neurologist took me off Cymbalta which was working and started me on Savella. I worked up to 100 mg. That night my heart rate skyrocket to 160 BPM. I went to emergency room thinking I was having a heart attack. I Googled the side effects of Savella and saw tachycardia on the list. I’m warning myself off. Really scary to think that doctors do not consider crossed side effects of multiple medications. Learned my lesson.”

2 / 10
Eton · Taken for 1 to 2 years June 26, 2019

For Fibromyalgia: “Cymbalta sent me on a downward spiral, whereas Milnacipran saved me. It works wonders for me. I can function again.”

10 / 10
Farris · Taken for less than 1 month June 18, 2019

Savella (milnacipran) for Fibromyalgia: “Just started Savella about 2 weeks ago for my Fibromyalgia pain. It has relieved my pain some but not liking the side effects at all which have included dizziness, abdominal pain & discomfort & anxiety. Still trying to weigh out whether this script is worth taking or not. Going to finish up dosage & then make a decision from there.”

5 / 10
Nettie · Taken for less than 1 month June 16, 2019

Savella (milnacipran) for Fibromyalgia: “This does help with the nerve pain, but I could not function even with the low dose. Gave me dizziness, felt high, no energy.”

3 / 10
Pain · Taken for less than 1 month June 11, 2019

Savella (milnacipran) for Fibromyalgia: “This help with inflammation ,however I believe it's like chemotherapy the side effects is horrible ,nausea ,vomiting just feel ugh!!!”

6 / 10
Charly April 3, 2019

Savella (milnacipran) for Fibromyalgia: “Almost killed me- literally. I am still not ok weeks later. This medication should not be on the shelf prescribed in too large of dosages AND not be monitored daily - yup that scary and yup called the doc called the pharmacist- this is a very very serious lethal bad reaction drug”

1 / 10
i · Taken for 1 to 6 months April 2, 2019

Savella (milnacipran) for Fibromyalgia: “I take Tramadol for my Fibro and it helps with pain but needed something for severe fatigue and listlessness. I started Savella 25 mg twice daily and went up to 50mg twice a day . The sweating is unbelievable. I change PJ's twice a night because I'm soaked. The last two days now I'm experiencing severe shakes , palpations, sweating when ever I want to clean something . I have to get off of it because I'm afraid something will happen to me. I have no difference In the fatigue at all all. I'm making a appointment with a neurologist in the hopes he can help .”

1 / 10
UCTDJill · Taken for less than 1 month February 8, 2019

Savella (milnacipran) for Fibromyalgia: “Have undifferentiated connective tissue disease, lupus markers, could be fibro. Anyway muscles hurt. Savella the first week gave me the feeling of loosing all hope. The feeling of why am I here? what is my purpose? I stopped taking, didn’t get through the first pack. I called pharmacist and asked how long will it take for this med to leave my system. He said 3 days. For me Tramadol works the best. Teva brand out of all.”

1 / 10
FreddyMeds · Taken for less than 1 month January 31, 2019

For Fibromyalgia: “AMAZING! Finally something that works. I have a severe case of fibromyalgia which leave me in excruciating nerve, joint and muscle pain together with cervical myelopathy. I have tried all the recommended medications for fibromyalgia including Pregabalin, Gabapentin, Duloxetine etc. as well as opiates. In the long run they didn't provide either adequate or sustained relief. Having tried so many medications & treatments, nothing worked for the relentless deep, stabbing, pulling & burning nerve pain that was destroying my quality of life together with horrible paralysing stiffness. Milnacipran is not approved for fibro in my country but I managed to get a private prescription for the generic. After only 5 days on 12.5mg I am amazed how all of my nerve and muscle pain has completely disappeared !!! My stiffness and joint pain is also c 70% reduced. I strongly recommend you try this medication. The side effects are pretty minimal too.”

9 / 10
Luckyprincess · Taken for 6 months to 1 year January 17, 2019

Savella (milnacipran) for Fibromyalgia: “I really wanted to love Savella. It seems ok the first 4 to 6 months I was on it until I started getting heart palpitations and short of breath, my heart rate would go up to almost 200 with minor tasks. I didn’t realize how bad it was I until I had to go to the ER to get checked out. Be careful on this med, when it works it works great but I was only on 50mg a day and I’m pretty sure it messed up my heart for good. The reason it hasn’t been approved in a lot go places over in Europe is because the risks outweigh the benefits in most of their studies.”

2 / 10
Oohma · Taken for less than 1 month December 12, 2018

Savella (milnacipran) for Fibromyalgia: “I was only on Savella 1 week when I developed a severe reaction to the medication. It started with migraine and within a day I had swelling of my throat and face. I had to make an emergency trip to the hospital.”

1 / 10

This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.