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Generic name: milnacipran (mil NA si pran)
Brand name: Savella, Savella Titration Pack
Dosage forms: oral tablet (100 mg; 12.5 mg; 25 mg; 50 mg; varying strength)
Drug class: Serotonin-norepinephrine reuptake inhibitors

Medically reviewed by on Mar 29, 2021. Written by Cerner Multum.

What is milnacipran?

Milnacipran is used to treat chronic pain caused by fibromyalgia (a medical condition that causes chronic pain in the muscles and joints).

Milnacipran may also be used for purposes not listed in this medication guide.


Some young people have thoughts about suicide when first taking milnacipran. Stay alert to changes in your mood or symptoms.

Do not use milnacipran if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. After you stop taking milnacipran, you must wait at least 5 days before you start taking an MAOI.

Milnacipran is not approved for use by anyone younger than 18 years old.

Before taking this medicine

You should not use milnacipran if you are allergic to it.

Do not use milnacipran if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, and tranylcypromine. After you stop taking milnacipran, you must wait at least 5 days before you start taking an MAOI.

Milnacipran should not be given to a child younger than 18 years old.

Tell your doctor if you have ever had:

Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with milnacipran and cause a serious condition called serotonin syndrome.

Some young people have thoughts about suicide when first taking milnacipran. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Taking this medicine during pregnancy may cause serious lung problems or other complications in the baby. Tell your doctor right away if you become pregnant. Do not start or stop taking this medicine during pregnancy without your doctor's advice.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of milnacipran on the baby.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

How should I take milnacipran?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Tell your doctor if you feel an increased urge to take more of milnacipran.

You may take medicine with or without food, but food may help you tolerate the medicine better.

Your blood pressure and heart rate will need to be checked often.

Do not stop using milnacipran suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using milnacipran.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include extreme drowsiness, slow heart rate, weak pulse, fainting, and slow breathing (breathing may stop).

What should I avoid while taking milnacipran?

Avoid driving or hazardous activity until you know how milnacipran will affect you. Your reactions could be impaired.

Avoid drinking alcohol.

Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others. Using an NSAID with milnacipran may cause you to bruise or bleed easily.

Milnacipran side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, depression, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

  • little or no urination;

  • blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;

  • a seizure;

  • a light-headed feeling, like you might pass out;

  • liver problems--stomach pain (upper right side), itching, dark urine, jaundice (yellowing of the skin or eyes);

  • low sodium level--headache, confusion, severe weakness, vomiting, problems with thinking or memory, feeling unsteady; or

  • manic episodes--racing thoughts, increased energy, unusual risk-taking behavior, extreme happiness, being irritable or talkative.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Some side effects may be more likely in older adults.

Common side effects may include:

  • nausea, vomiting, constipation;

  • dry mouth;

  • increased blood pressure;

  • fast or pounding heartbeats;

  • increased sweating, flushing (warmth, redness, or tingly feeling);

  • headache, dizziness; or

  • trouble sleeping.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Milnacipran dosing information

Usual Adult Dose for Fibromyalgia:

Maintenance dose: 50 mg orally 2 times a day
Maximum dose: 100 mg orally 2 times a day (200 mg orally per day)

-Dosing may be titrated according to the following schedule:
-Initial dose on day 1: 12.5 mg orally once
-Days 2 and 3: 12.5 mg orally 2 times a day
-Days 4 through 7: 25 mg orally 2 times a day
-After day 7: 50 mg orally 2 times a day

Use: Management of fibromyalgia

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What other drugs will affect milnacipran?

Using milnacipran with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Other drugs may affect milnacipran, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.