Medically reviewed on January 9, 2017
What is milnacipran?
Milnacipran affects certain chemicals in the brain called neurotransmitters. An abnormality in these chemicals is thought to be related to fibromyalgia (a medical condition that causes chronic pain in the muscles and joints). Milnacipran is not used to treat depression but it works similarly to how some antidepressants work.
Milnacipran is used to treat the chronic pain caused by fibromyalgia.
Milnacipran may also be used for purposes not listed in this medication guide.
Do not use milnacipran if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. After you stop taking milnacipran, you must wait at least 5 days before you start taking an MAOI.
Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms.
Milnacipran is not approved for use by anyone younger than 18 years old.
Before taking this medicine
You should not use milnacipran if you are allergic to it.
Do not use milnacipran if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others. After you stop taking milnacipran, you must wait at least 5 days before you start taking an MAOI.
To make sure milnacipran is safe for you, tell your doctor if you have:
heart disease, high blood pressure;
bipolar disorder (manic depression);
a bleeding or blood clotting disorder such as hemophilia;
low levels of sodium in your blood;
problems with urination;
if you drink alcohol.
Some young people have thoughts about suicide when first taking milnacipran. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.
Taking this medicine during pregnancy may cause serious lung problems or other complications in the baby. However, you may have a relapse of your symptoms if you stop taking milnacipran. Tell your doctor right away if you become pregnant. Do not start or stop taking this medicine during pregnancy without your doctor's advice.
If you are pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of milnacipran on the baby.
Milnacipran can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
Milnacipran should not be given to a child younger than 18 years old.
How should I take milnacipran?
Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use milnacipran in larger or smaller amounts or for longer than recommended.
You may take medicine with or without food, but food may help you tolerate the medicine better.
Your blood pressure and heart rate will need to be checked often.
Do not stop using milnacipran suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using milnacipran.
Tell your doctor if the medicine seems to stop working as well in relieving your fibromyalgia pain.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include extreme drowsiness, slow heart rate, weak pulse, fainting, and slow breathing (breathing may stop).
What should I avoid while taking milnacipran?
Avoid drinking alcohol.
Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) for pain, arthritis, fever, or swelling. This includes aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others. Using an NSAID with milnacipran may cause you to bruise or bleed easily.
Milnacipran may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Milnacipran side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, depression, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have:
a light-headed feeling, like you might pass out;
pounding heartbeats or fluttering in your chest;
blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
little or no urinating;
manic episodes--racing thoughts, increased energy, unusual risk-taking behavior, extreme happiness, being irritable or talkative;
low levels of sodium in the body--headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady;
liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
dangerously high blood pressure--severe headache, blurred vision, pounding in your neck or ears, nosebleed, anxiety, confusion, severe chest pain, shortness of breath, irregular heartbeats.
Some side effects may be more likely in older adults.
Common side effects may include:
nausea, vomiting, constipation;
increased sweating, flushing (warmth, redness, or tingly feeling);
sleep problems (insomnia); or
high blood pressure, pounding heartbeat.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
Milnacipran dosing information
Usual Adult Dose for Fibromyalgia:
Maintenance dose: 50 mg orally 2 times a day
Maximum dose: 100 mg orally 2 times a day (200 mg orally per day)
-Dosing may be titrated according to the following schedule:
-Initial dose on day 1: 12.5 mg orally once
-Days 2 and 3: 12.5 mg orally 2 times a day
-Days 4 through 7: 25 mg orally 2 times a day
-After day 7: 50 mg orally 2 times a day
Use: Management of fibromyalgia
What other drugs will affect milnacipran?
Taking milnacipran with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking milnacipran with a sleeping pill, narcotic pain medicine, prescription cough medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.
Some medicines can interact with milnacipran and cause a serious condition called serotonin syndrome. Be sure your doctor knows if you also take medicine for depression, mental illness, Parkinson's disease, migraine headaches, ADHD, narcolepsy, serious infections, or prevention of nausea and vomiting. Ask your doctor before making any changes in how or when you take your medications.
Other drugs may interact with milnacipran, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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More about milnacipran
- Milnacipran Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- En Español
- 316 Reviews
- Drug class: serotonin-norepinephrine reuptake inhibitors
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