Skip to main content

Cymbalta for Diabetic Peripheral Neuropathy User Reviews

Cymbalta has an average rating of 6.2 out of 10 from a total of 39 reviews for the treatment of Diabetic Peripheral Neuropathy. 56% of reviewers reported a positive experience, while 36% reported a negative experience.

Cymbalta rating summary

6.2/10 average rating

39 ratings from 42 user reviews.

Compare all 28 medications used in the treatment of Diabetic Peripheral Neuropathy.

10
23%
9
15%
8
18%
7
0%
6
5%
5
3%
4
0%
3
10%
2
3%
1
23%

Reviews for Cymbalta

  • Julles
  • May 26, 2020

"Took Cymbalta for severe nerve pain. (Hemangioblastoma removal inside spinal cord @ C4,5,6). It worked well for the pain and I had little side effects. Came to a point my doctor and I decided I didn’t need it anymore. Then the fun began. I don’t care what kind of issue you have or how much pain you are in - DO NOT TAKE THIS MEDICATION! Trying to get off this was the worst thing I could ever have imagined and it went on for months!! The list of symptoms was long and bizarre. I can’t stress enough how bad it was...please, please don’t take even 1. PS To Loulou: after being deathly ill for weeks I called my doctor, again, and they told me to just start taking it again and start tapering off again at another time! What?!? No frigging way so I suffered through almost six months of horrid withdrawal. It does go away, I promise! You aren’t alone - I felt EXACTLY the same way you do now! Hang in and do not start taking it again!! Good luck to you!"

1 / 10
Was this helpful?YesNo
65 Report
  • jesss...
  • February 10, 2015

"I was originally put on Cymbalta for depression. I was told to take it during the day, which I did. When I took the Cymbalta during the day, it made me incredibly sleepy to the point where I could not stay awake, so I discontinued its use. Fast forward a few years, and I started experiencing HORRIBLE Diabetic Peripheral Neuropathy. The doctor put me on Cymbalta to try and treat the pain. This time, I took it before bed. I didn't notice any sleepiness during the day, and my nerve pain got better, and eventually was completely gone. After a year of use and almost no pain at all, I started having some 'breakthrough pain'. Even though I am having 'breakthrough pain' after a year, the Cymbalta still makes life 100x better, and I am grateful to have it!"

10 / 10
Was this helpful?YesNo
107 Report
  • Anonymous
  • Taken for 2 to 5 years
  • January 27, 2016

"I have been on Cymbalta for over 2 years. I have M.S. and am a type 1 diabetic with severe neuropathy. Before this medication, the searing pain in my legs was unbearable. I could not walk because of it. I was originally put on gabapentin, and had such severe side effects that I quit taking it. My neurologist then prescribed me Cymbalta. He started me on a low dose, then after a month doubled it. Since then, I experience little to no pain. When I am a bit uncomfortable, I get in a warm bath and the pain is gone. I sleep better, have better control over my blood sugar as it does suppress appetite, but that means I am not munching or overeating. I cannot live without it!!!"

10 / 10
Was this helpful?YesNo
97 Report

Frequently asked questions

  • Anonymous
  • Taken for less than 1 month
  • January 25, 2013

"I'm a Type 1 Diabetic for 39 years. Had VERY painful muscle spasms/seizing and twitching. I tried various supplements which 'should' have helped but no improvement. I started Neurontin at 1,800mg/day and I had terrible swelling plus gained 18 lbs in 6 months (and my eating habits actually got better while on it). The 1,800mg of Neurontin no longer controlled the muscle spasms. I started Cymbalta, 30 mg before bed, and had significant reduction in pain the first morning. I did notice a very strong headache that first day. I had only 3-4 muscle spasms that first day as well...Wow!! Second day...almost NO pain in the morning and only a dull headache with much weaker muscle spasms. Side effects: Crazy dreams, difficulty sleeping, headache."

8 / 10
Was this helpful?YesNo
95 Report
  • Raz
  • August 5, 2016

"I have been taking the drug for just a little over 3 weeks , I want a life membership for this Drug , I hardly have any pain , I can feel my feet and feel great on it , I am one of the lucky ones after reading many posts , i Have had nerve pain for almost 3 years and it has been brutal , I have tied amtatriplean , and lyrica , both did not wok , feeling way better"

10 / 10
Was this helpful?YesNo
68 Report

Are you taking this medicine?

  • Potomac
  • March 10, 2015

"Excellent results with Cymbalta on 30mg once each night. Burning pain reduced by about 80%. Does generate dreams, but not uncomfortable dreams. This is the first medicine that helped. Side effects were too great with Neurontin; felt little to no effect with Lyrica."

10 / 10
Was this helpful?YesNo
68 Report
  • Anonymous
  • Taken for 1 to 2 years
  • September 14, 2012

"I was not sure how well it worked at first. Then I was unable to get it for a while, and was in a lot of pain, having trouble getting through the day. I just wanted to sleep. Once back in my system, I noticed the difference. This helps my depression, back pain, and the neuropathy."

9 / 10
Was this helpful?YesNo
74 Report

More FAQ

  • Kimbe...
  • July 25, 2009

"I've tried many, many different medicines for my nerve pain. Finally after being put on Cymbalta for my depression, I noticed that my nerve pain was not near as bad as it was before. I'm overwhelmed with my results. Almost to tears of joy, instead of tears of pain! Thank you!"

10 / 10
Was this helpful?YesNo
80 Report
  • hmmmm...
  • October 4, 2017

"I have taken Cymbalta for 12 years for Peripheral Neuropathy. The prior 15 years I had what felt like a million little electric eels burrowing just under the skin of my right thigh. Or it felt like my thigh was packed in ice. For 15 years I was blown off by every doctor I saw under my insurance. A Dr not covered by my insurance prescribed Cymbalta. I had an immediate improvement, which just kept getting better. 0 side effects. A year in and things unrelated to the neuropathy improved dramatically. A hand tremor went away, I no longer fell a lot. Eventually Kaiser would cover the Generic, which makes me throw up."

Was this helpful?YesNo
42 Report
  • Frosty
  • Taken for 2 to 5 years
  • June 11, 2019

"Diagnosed with Idiopathic Small Nerve fiber neuropathy and eventually put on Cymbalta. 60 mg daily. Been taking it for 5 years. First week was difficult but my Neurologist encouraged me to soldier through. Relief began after about the 5th day. My main complaint is fatigue. On the upside, I sleep like a teenager. I’m retired so I can sleep in. I don’t think I would be able to work on this though. Recently, I discovered I can get by with 60 mg every other day. That’s what brought me here. Looking for info about that. I have an appointment with my Neurologist in July and wanted more info before I discuss my condition"

10 / 10
Was this helpful?YesNo
32 Report
  • JoNigle
  • October 27, 2009

"Cymbalta was the first drug that actually improved the diabetic neuropathy pain I was experiencing in my legs, feet, arms and hands. For the first time, I was able to sleep through the night without waking in tears from the pain. I was so happy my doctor put me on this drug in conjunction with Neurontin. The pain almost disappeared! Approximately 6-8 weeks later, I noticed that the neuropathy pain started back up again despite continuing on the medicines. I too, had insomnia making it difficult, at best, to be alert, focused or have any energy the following day. To this day, I still have some insomnia and an increase in the neuropathy symptoms; BUT Cymbalta 60mg & Neurontin 600mg are the BEST drugs so far in lessening the pain."

9 / 10
Was this helpful?YesNo
69 Report
  • Amoya
  • Taken for 1 to 6 months
  • September 8, 2017

"I'm a recovering alcoholic of 16 years. I was diagnosed diabetic in 2008 and continued drinking until May 7th 2017. Unfortunately my addiction had caused a lot of damage to my body that I didn't notice while consuming 3-6 gallons of beer a day. In the past if I didn't have a drink I would start to feel pain in my legs so I drank more. Now after the first I weeks and the shakes went away I went to a doctor to get my health checked. After fully disclosing my situation he prescribed gabapentin.. I had a bad skin burring reaction after a few weeks and my legs and feet were like lighting storms of pain. He then prescribed Cymbalta. I was reluctant at first reading all the side effects. But now I take it 2 hours before bed and the pain is gone."

8 / 10
Was this helpful?YesNo
38 Report
  • Ssand...
  • Taken for less than 1 month
  • December 4, 2016

"I've been on Cymbalta/30mg for 1 week. Strong diarrhea first night, missed work the next day. Since then little trouble sleeping, napping on my days off. I work 12 hr shifts on my feet on a cement floor. I lost the feeling in my toes almost a year ago. Dealt with the hot coals burning on the bottom of my feet also. In such a short length of time I have had some relief in the burning of my soles and with the back pain. Hoping for continued improvement"

8 / 10
Was this helpful?YesNo
41 Report
  • Anonymous
  • February 1, 2010

"I have peripheral neuropathy and very bad pain in my back. Cymbalta made a huge improvement in my pain level. The doctor started me gradually to lessen the nausea. I have worked up to 30 mg. twice a day for a total of 60 mg. I have been taking it for 3 months and still find the pain level, and my frame of mind, much improved. I do have slight nausea occasionally, and dry mouth. The excessive sweating has gone away."

8 / 10
Was this helpful?YesNo
65 Report
  • Kitty
  • Taken for less than 1 month
  • November 28, 2020

"Horrible. Made my stomach upset, groggy, nausea, anxiety worse. After one day!!!I can't handle it. I can't believe how hard it is to find decent pain relief. Inhumane to keep someone alive with nerve pain."

1 / 10
Was this helpful?YesNo
23 Report
  • samit...
  • October 14, 2015

"I was on Cymbalta for a few years, and over that time, I didn't notice a significant reduction in the pain, but I did notice that my memory started to diminish. I asked my doctor to take me off of it, but he refused, so I quit cold-turkey. The side effects are significant and severe! I wouldn't suggest this tactic! All in all, I'm very happy to be off of it... my memory is improving noticeably, and the foot pain is just about the same."

3 / 10
Was this helpful?YesNo
39 Report
  • Justme
  • Taken for 1 to 6 months
  • October 15, 2017

"Was prescribed 20mg of this when my hands started burning, which caused me more anxiety than the idiopathic nerve damage in my feet that was detected on an EMG. Feeling much less anxious, NO nerve pain in my hands, and 80-90% less tingling/vibrating in my feet. The first week on this I had severe headaches in the morning, which I pushed thru and didn't have after about 10 days. I feel noticeably less energetic and groggy in the morning than I used to. Other than that, I haven't noticed any side effects, and I usually react to medications (which makes me cautious). I am not on ANY other meds. I would rate this a 10, but the awful headaches in the morning were a pain and feeling groggy until noon-ish is tolerable but not ideal."

Was this helpful?YesNo
32 Report
  • Fuzzy...
  • Taken for less than 1 month
  • June 6, 2019

"Joined this website solely to warn others that the side effects of Cymbalta were worse than any other med ever. After taking for 10 days nearly all the side effects that others mention were experienced, after stopping the scariest pains were felt down the middle of left arm and less down the right, groin pain radiating down the left leg and less down the right and the feeling someone was pushing their thumb into my neck on my jugular."

1 / 10
Was this helpful?YesNo
25 Report
  • MJano
  • Taken for 1 to 6 months
  • August 30, 2019

"I've been taking Cymbalta for 6 months 20 mg once a day it has helped with my neuropathy in my legs but nothing has stopped it so it's better than taking nothing which causes pain that is unbearable. But when taking the 60 mg it has me very nauseated and off balance. So I have not been able to take a larger amount, then 20 mg a day. I tried taking it at night but I was really restless oh, so I take it in the morning with food."

8 / 10
Was this helpful?YesNo
21 Report
  • Billi...
  • Taken for 10 years or more
  • August 7, 2017

"I have taken 60mg for 20 years. Three weeks ago my Dr. dropped the dosage to 30 mg. I had some hateful and days of crying. Now that passed but my feet and legs and lower back hurt so bad I can barely walk. Is this normal and would it stop if I took 60 again."

9 / 10
Was this helpful?YesNo
27 Report
  • dyot
  • Taken for 1 to 6 months
  • December 8, 2015

"Not diabetic neuropathy, but neuropathic pain nonetheless. Works wonderfully... ...except for the terrible acne it's causing, and the relatively frequent but terrible headaches. I also have some issues with anxiety; it has done exactly nothing of use there."

8 / 10
Was this helpful?YesNo
30 Report
  • Anonymous
  • Taken for 1 to 6 months
  • March 25, 2018

"I’ve been taking 30 mg a day for a few months, prescribed partly for depression but mainly for neuropathy. I’ve noticed a marked reduction in pain, a minimal positive effect on depression but the skyrocketing anxiety is crazy. It seemed to actually decrease anxiety for about a week, then went in the opposite direction. I asked my doctor about this, and discontinuing it, but he said not to, and instead go to 60 mg. This has put me in an awkward position of noncompliance (for good cause IMO). Ultimately though, I guess it’s my responsibility. If I don’t notice a decrease in the anxiety soon I’ll be stopping Cymbalta. No sense in paying a doctor to feel worse!"

3 / 10
Was this helpful?YesNo
24 Report
  • Anonymous
  • June 9, 2009

"Debilitating side effects after only 2 hours with only one 60mg pill. Extreme sweating, fatigue, difficulty swallowing and walking. Next came the nausea and intense insomnia. Had to call in sick to work the next day due to lack of sleep and weakness. Didn't get out of bed until 3 pm."

1 / 10
Was this helpful?YesNo
38 Report
  • Terry...
  • October 20, 2009

"It was like a wonder drug at first. Then, even though I went up to the maximum dose of 60 mg, I can no longer tell I am even taking it. I stop it - then start it back up - still no help. It's just no good anymore."

3 / 10
Was this helpful?YesNo
37 Report
  • hemaro
  • April 6, 2009

"Cymbalta has been a lifesaver for my Diabetic Neuropathy. In just a few days the pain and discomfort went away. The only problem I am facing with Cymbalta is insomnia even in combination with Xanax 4mg and Vistaril 150mg."

9 / 10
Was this helpful?YesNo
35 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.

Learn more about Diabetic Peripheral Neuropathy

Medicine.com guides (external)