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Cymbalta Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Cymbalta Remove Cymbalta from your drug comparison Bupropion Remove Bupropion from your drug comparison Zoloft Remove Zoloft from your drug comparison
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Cymbalta duloxetine Remove Cymbalta from your drug comparison Bupropion Remove Bupropion from your drug comparison Zoloft sertraline Remove Zoloft from your drug comparison

Cymbalta has antidepressant, anti-anxiety, and pain-relieving properties; however, it has been associated with a discontinuation syndrome on withdrawal even when tapered. Prescribed for Back Pain... View more

Bupropion may be used in the treatment of depression or as an aid to smoking cessation; however, side effects may include insomnia, neuropsychiatric adverse events, or seizures. It carries a black... View more

Zoloft is an effective antidepressant with less potential for drowsiness than many other antidepressants. Prescribed for Panic Disorder, Obsessive Compulsive Disorder, Major Depressive Disorder... View more

Prescription only

Prescription only

Prescription only

Ratings & Reviews

View all 1605 reviews

View all 2447 reviews

View all 1639 reviews

Drug Class

Side Effects

Common side effects include: asthenia, constipation, diarrhea, dizziness, drowsiness, fatigue, hypersomnia, insomnia, nausea, sedated state, headache, xerostomia.

See the full Cymbalta side effects document.

Commonly reported side effects include: insomnia, nausea, pharyngitis, weight loss, constipation, dizziness, headache, xerostomia.

See the full bupropion side effects document.

Common side effects include: diarrhea, dizziness, drowsiness, dyspepsia, fatigue, insomnia, loose stools, nausea, tremor, headache, paresthesia, anorexia, decreased libido, delayed ejaculation, diaphoresis, ejaculation failure, xerostomia.

See the full Zoloft side effects document.

Pricing and Coupons

* Prices are without insurance
Quantity 21 delayed release capsule
Dosage 60 mg
Per Unit* $11.61
Cost* $243.73

View all Cymbalta prices and generic prices

Quantity 30 each
Dosage 150 mg/24 hours
Per Unit* $1.64
Cost* $49.22

View all bupropion prices

Quantity 30 tablet
Dosage 100 mg
Per Unit* $13.13
Cost* $393.84

View all Zoloft prices and generic prices

Get free Discount Card

Get free Discount Card

Get free Discount Card

Generic Availability

Yes

Yes (this medicine)

Yes

Dosage Form(s) Available
  • Oral delayed release capsule
  • Oral tablet
  • Oral tablet, extended release
  • Oral concentrate
  • Oral tablet

Brand Names
Other duloxetine brands include: Drizalma Sprinkle, Irenka Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR, Wellbutrin XL Other sertraline brands include: Zercapli

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

17 hours

30 hours

66 hours

CSA Schedule**

View glossary of terms.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category
C
Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.
C
Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.
C
Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Drug Interactions

A total of 568 drugs are known to interact with Cymbalta:

  • 101 major drug interactions (451 brand and generic names)
  • 444 moderate drug interactions (1936 brand and generic names)
  • 23 minor drug interactions (181 brand and generic names)

A total of 423 drugs are known to interact with bupropion:

  • 212 major drug interactions (925 brand and generic names)
  • 206 moderate drug interactions (862 brand and generic names)
  • 5 minor drug interactions (16 brand and generic names)

A total of 630 drugs are known to interact with Zoloft:

  • 144 major drug interactions (566 brand and generic names)
  • 480 moderate drug interactions (1994 brand and generic names)
  • 6 minor drug interactions (26 brand and generic names)

Alcohol/Food/Lifestyle Interactions
  • DULoxetine may cause liver damage, and taking it with alcohol may increase that risk. You should... View more
  • Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures... View more
  • You should avoid or limit the use of alcohol while being treated with sertraline. Alcohol can... View more

Disease Interactions

First Approval Date

N/A

December 30, 1985

December 30, 1991

WADA Class

View World Anti-Doping Agency classifications.

N/A

N/A

N/A

More Information

Consumer Resources

Professional Resources

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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