Skip to main content
Print

Cymbalta Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Cymbalta Buprenex Oxycodone
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Cymbalta (duloxetine) Buprenex (buprenorphine) Oxycodone
Prescription only

Cymbalta has antidepressant, anti-anxiety, and pain-relieving properties; however, it has been associated with a discontinuation syndrome on withdrawal even when tapered. Prescribed for Back Pain... View more

Prescription only

Buprenex is a potent analgesic that should be only used to treat moderate to severe pain under strict conditions when other analgesics have proved inadequate. Sedation is the main side effect and it... View more

Prescription only

Oxycodone is a potent pain-relieving medicine that should be reserved for mainly cancer-related pain. It carries a high potential for addiction and common side effects include sedation and... View more

More about Cymbalta (duloxetine) More about Buprenex (buprenorphine) More about Oxycodone
Generic Status

Lower-cost generic is available

Lower-cost generic is available

Lower-cost generic is available
Ratings & Reviews

Cymbalta has an average rating of 6.2 out of 10 from a total of 1826 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 30% reported a negative effect.

Buprenex has an average rating of 8.4 out of 10 from a total of 6 ratings on Drugs.com. 80% of reviewers reported a positive effect, while 20% reported a negative effect.

Oxycodone has an average rating of 7.0 out of 10 from a total of 1108 ratings on Drugs.com. 63% of reviewers reported a positive effect, while 24% reported a negative effect.

View all 1826 reviews

View all 6 reviews

View all 1108 reviews

Drug Class
Side Effects

Common side effects include:

  • asthenia
  • constipation
  • diarrhea
  • dizziness
  • drowsiness
  • fatigue
  • hypersomnia
  • insomnia
  • nausea
  • sedated state
  • headache
  • xerostomia
  • show all 12

See also: Cymbalta side effects in more detail.

See also: Buprenex side effects in more detail.

Commonly reported side effects include:

  • constipation
  • drowsiness
  • nausea
  • pruritus
  • vomiting

See also: oxycodone side effects in more detail.
Pricing and Coupons * Prices are without insurance
Quantity 30 delayed release capsule
Dosage 60 mg
Per Unit* $10.16
Cost* $304.87

View all Cymbalta prices and generic prices

Quantity 5 mL
Dosage 0.3 mg/mL
Per Unit* $17.87
Cost* $89.37

View all Buprenex prices and generic prices

Quantity 100 each
Dosage 5 mg
Per Unit* $0.26
Cost* $26.23

View all oxycodone prices

Get free Discount Card

Get free Discount Card

Get free Discount Card

Dosage Form(s) Available
  • Oral delayed release capsule
  • Injectable solution
  • Oral capsule
  • Oral concentrate
  • Oral solution
  • Oral tablet
  • Oral tablet, extended release
Brand Names
Other duloxetine brands include: Drizalma Sprinkle, Irenka Other buprenorphine brands include: Belbuca, Butrans, Sublocade Dazidox, Endocodone, ETH-Oxydose, Oxaydo, OxyContin, Oxydose, Oxyfast, Roxicodone, RoxyBond, Xtampza ER View more
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

17 hours

48 hours

5.6 hours
CSA Schedule ** View glossary of terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
3
Moderate abuse potential

Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
2
High potential for abuse

Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
Pregnancy Category
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
N
Category N Not classified

See the full pregnancy warnings document.
Drug Interactions

A total of 578 drugs are known to interact with Cymbalta:

  • 104 major drug interactions (459 brand and generic names)
  • 451 moderate drug interactions (1963 brand and generic names)
  • 23 minor drug interactions (182 brand and generic names)

A total of 662 drugs are known to interact with Buprenex:

  • 201 major drug interactions (686 brand and generic names)
  • 457 moderate drug interactions (1843 brand and generic names)
  • 4 minor drug interactions (9 brand and generic names)

A total of 561 drugs are known to interact with oxycodone:

  • 208 major drug interactions (746 brand and generic names)
  • 352 moderate drug interactions (1404 brand and generic names)
  • 1 minor drug interactions (3 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • DULoxetine may cause liver damage, and taking it with alcohol may increase that risk. You should... View more
  • Using buprenorphine together with other medications that also cause central nervous system... View more
  • Do not use alcohol or medications that contain alcohol while you are receiving treatment with... View more
Disease Interactions
First Approval Date

N/A

N/A

October 20, 2010
WADA Class View World Anti-Doping Agency classifications.

N/A
More Information
Patient resources

N/A
Professional Resources
Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Compare Drugs

To view a report comparing 3 (or more) medications, please sign in or create an account.

Create an account Sign In