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Medications for Migraine Prevention (Migraine Prophylaxis)

About Migraine Prevention

Measures taken to prevent migraine headaches, a type of headache that some people get repeatedly over time.

Drugs used for Migraine Prevention

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
topiramate 5.9 603 reviews
Rx D N X

Generic name: topiramate systemic

Brand names:  Topamax, Qudexy XR

Drug class: carbonic anhydrase inhibitor anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Topamax 6.0 356 reviews
Rx D N X

Generic name: topiramate systemic

Drug class: carbonic anhydrase inhibitor anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

propranolol 7.5 184 reviews
Rx C N X

Generic name: propranolol systemic

Brand names:  Inderal LA, InnoPran XL

Drug class: non-cardioselective beta blockers, group II antiarrhythmics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Botox 6.2 130 reviews
Rx C N

Generic name: onabotulinumtoxinA systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

amitriptyline Off-label 7.7 332 reviews
Rx C N X

Generic name: amitriptyline systemic

Drug class: tricyclic antidepressants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off-label: Yes

Aimovig 4.8 507 reviews
Rx N

Generic name: erenumab systemic

Drug class: CGRP inhibitors

For consumers: dosage, side effects

For professionals: Prescribing Information

Emgality 4.7 261 reviews
Rx N

Generic name: galcanezumab systemic

Drug class: CGRP inhibitors

For consumers: dosage, side effects

For professionals: Prescribing Information

Ajovy 5.6 116 reviews
Rx N

Generic name: fremanezumab systemic

Drug class: CGRP inhibitors

For consumers: dosage, side effects

For professionals: Prescribing Information

onabotulinumtoxinA 6.3 132 reviews
Rx C N

Generic name: onabotulinumtoxinA systemic

Brand name:  Botox

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

erenumab 4.8 512 reviews
Rx N

Generic name: erenumab systemic

Brand name:  Aimovig

Drug class: CGRP inhibitors

For consumers: dosage, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

fremanezumab 5.6 117 reviews
Rx N

Generic name: fremanezumab systemic

Brand name:  Ajovy

Drug class: CGRP inhibitors

For consumers: dosage, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

galcanezumab 4.7 262 reviews
Rx N

Generic name: galcanezumab systemic

Brand name:  Emgality

Drug class: CGRP inhibitors

For consumers: dosage, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

Vyepti Rate Add review
Rx N

Generic name: eptinezumab systemic

Drug class: CGRP inhibitors

For consumers: dosage, side effects

For professionals: Prescribing Information

nortriptyline Off-label 7.8 184 reviews
Rx N N X

Generic name: nortriptyline systemic

Drug class: tricyclic antidepressants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off-label: Yes

Benicar Off-label 9.7 3 reviews
Rx D N

Generic name: olmesartan systemic

Drug class: angiotensin receptor blockers

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Off-label: Yes

verapamil 7.6 58 reviews
Rx C N X

Generic name: verapamil systemic

Brand names:  Calan SR, Calan, Verelan, Isoptin SR, Verelan PM …show all

Drug class: calcium channel blocking agents, group IV antiarrhythmics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Norvasc Off-label 9.3 7 reviews
Rx C N

Generic name: amlodipine systemic

Drug class: calcium channel blocking agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Off-label: Yes

amlodipine Off-label 9.0 48 reviews
Rx C N

Generic name: amlodipine systemic

Brand name:  Norvasc

Drug class: calcium channel blocking agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off-label: Yes

Depakote 6.0 42 reviews
Rx D N X

Generic name: divalproex sodium systemic

Drug class: fatty acid derivative anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

baclofen Off-label 6.9 18 reviews
Rx C N X

Generic name: baclofen systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off-label: Yes

lisinopril Off-label 9.0 26 reviews
Rx D N

Generic name: lisinopril systemic

Drug class: Angiotensin Converting Enzyme Inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off-label: Yes

Zonegran Off-label 7.2 19 reviews
Rx C N X

Generic name: zonisamide systemic

Drug class: carbonic anhydrase inhibitor anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Off-label: Yes

atenolol 7.9 28 reviews
Rx D N X

Generic name: atenolol systemic

Brand name:  Tenormin

Drug class: cardioselective beta blockers

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

zonisamide Off-label 6.1 46 reviews
Rx C N X

Generic name: zonisamide systemic

Brand name:  Zonegran

Drug class: carbonic anhydrase inhibitor anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off-label: Yes

Calan SR 10 3 reviews
Rx C N X

Generic name: verapamil systemic

Drug class: calcium channel blocking agents, group IV antiarrhythmics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Alternative treatments for Migraine Prevention

The following products are considered to be alternative treatments or natural remedies for Migraine Prevention. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However there may be historical, cultural or anecdotal evidence linking their use to the treatment of Migraine Prevention.

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription Only.
OTC Over the Counter.
Rx/OTC Prescription or Over the Counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
EUA An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.