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Medications for Migraine Prevention (Migraine Prophylaxis)

About Migraine Prevention:  Measures taken to prevent migraine headaches, a type of headache that some people get repeatedly over time.

Drugs Used for Migraine Prevention

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Popularity
Topamax D N X 316 reviews
6.0

Generic name: topiramate systemic

Drug class: carbonic anhydrase inhibitor anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

topiramate D N X 504 reviews
6.0

Generic name: topiramate systemic

Brand names:  Topamax, Topamax Sprinkle, Topiragen, Qudexy XR …show all

Drug class: carbonic anhydrase inhibitor anticonvulsants

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

propranolol C N X 154 reviews
7.0

Generic name: propranolol systemic

Brand names:  Inderal, Inderal LA, InnoPran XL

Drug class: non-cardioselective beta blockers, group II antiarrhythmics

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

amitriptyline Off Label C N X 283 reviews
7.0

Generic name: amitriptyline systemic

Drug class: tricyclic antidepressants

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

Benicar Off Label D N 3 reviews
9.0

Generic name: olmesartan systemic

Drug class: angiotensin receptor blockers

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Off Label: Yes

verapamil C N X 47 reviews
7.0

Generic name: verapamil systemic

Brand names:  Calan SR, Calan, Verelan, Isoptin SR, Verelan PM …show all

Drug class: calcium channel blocking agents, group IV antiarrhythmics

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

nortriptyline Off Label N N X 163 reviews
8.0

Generic name: nortriptyline systemic

Drug class: tricyclic antidepressants

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

Norvasc Off Label C N 5 reviews
9.0

Generic name: amlodipine systemic

Drug class: calcium channel blocking agents

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Off Label: Yes

Inderal C N X 29 reviews
7.0

Generic name: propranolol systemic

Drug class: non-cardioselective beta blockers, group II antiarrhythmics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

amlodipine Off Label C N 32 reviews
8.0

Generic name: amlodipine systemic

Brand name:  Norvasc

Drug class: calcium channel blocking agents

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

Depakote D N X 35 reviews
5.0

Generic name: divalproex sodium systemic

Drug class: fatty acid derivative anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Botox C N 90 reviews
6.0

Generic name: onabotulinumtoxinA systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Lioresal Off Label C N X 2 reviews
10

Generic name: baclofen systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Off Label: Yes

Zonegran Off Label C N X 16 reviews
7.0

Generic name: zonisamide systemic

Drug class: carbonic anhydrase inhibitor anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Off Label: Yes

baclofen Off Label C N X 13 reviews
7.0

Generic name: baclofen systemic

Brand names:  Lioresal, Kemstro

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

atenolol D N X 24 reviews
8.0

Generic name: atenolol systemic

Brand name:  Tenormin

Drug class: cardioselective beta blockers

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Tenormin D N X 3 reviews
9.0

Generic name: atenolol systemic

Drug class: cardioselective beta blockers

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Calan SR C N X 3 reviews
10

Generic name: verapamil systemic

Drug class: calcium channel blocking agents, group IV antiarrhythmics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

divalproex sodium D N X 67 reviews
6.0

Generic name: divalproex sodium systemic

Brand names:  Depakote, Depakote ER, Depakote Sprinkles

Drug class: fatty acid derivative anticonvulsants

For consumers: dosage, interactions,

For professionals: Prescribing Information

lisinopril Off Label D N 20 reviews
8.0

Generic name: lisinopril systemic

Drug class: Angiotensin Converting Enzyme Inhibitors

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

Depakote ER D N X 22 reviews
7.0

Generic name: divalproex sodium systemic

Drug class: fatty acid derivative anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

olmesartan Off Label D N 5 reviews
9.0

Generic name: olmesartan systemic

Brand name:  Benicar

Drug class: angiotensin receptor blockers

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

zonisamide Off Label C N X 37 reviews
6.0

Generic name: zonisamide systemic

Brand name:  Zonegran

Drug class: carbonic anhydrase inhibitor anticonvulsants

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

clonazepam Off Label D 4 X 23 reviews
8.0

Generic name: clonazepam systemic

Drug class: benzodiazepines, benzodiazepine anticonvulsants

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

Inderal LA C N X 9 reviews
6.0

Generic name: propranolol systemic

Drug class: non-cardioselective beta blockers, group II antiarrhythmics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

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Alternative treatments for Migraine Prevention

The following products are considered to be alternative treatments or natural remedies for Migraine Prevention. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However there may be historical, cultural or anecdotal evidence linking their use to the treatment of Migraine Prevention.

Legend

Off Label This medication may not be approved by the FDA for the treatment of this condition.
Prescription Only / Over the Counter
Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Pregnancy
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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