Amlodipine Side Effects
Medically reviewed by Drugs.com. Last updated on Oct 11, 2021.
Commonly reported side effects of amlodipine include: edema. Other side effects include: fatigue, palpitations, and flushing. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to amlodipine: oral capsules, oral tablets
Side effects include:
Edema, dizziness, flushing, palpitations, fatigue, nausea, abdominal pain, somnolence. Edema, flushing, palpitations, and somnolence may be more common in women than men. Edema may be less frequent with concomitant ACE inhibitor or angiotensin II receptor antagonist therapy.
For Healthcare Professionals
Applies to amlodipine: oral liquid, oral suspension, oral tablet, oral tablet disintegrating
Edema occurred in 14.6% of female patients given this drug compared to 5.6% of male patients, and was more likely to occur in patients given the 10 mg dose (compared to the 5 and 2.5 mg doses).[Ref]
Very common (10% or more): Edema (up to 14.6%)
Common (1% to 10%): Palpitations, ankle edema
Uncommon (0.1% to 1%): Hypotension, chest pain
Very rare (less than 0.01%): Myocardial infarction, arrhythmia (including bradycardia, ventricular tachycardia, atrial fibrillation), vasculitis, cardiac failure, pulse irregularity, extrasystoles, hot flush
Frequency not reported: Tachycardia, peripheral ischemia, postural hypotension[Ref]
Common (1% to 10%): Somnolence, dizziness, headache
Uncommon (0.1% to 1%): Tremor, taste perversion/dysgeusia, syncope, hypoesthesia, paresthesia
Headache occurred commonly during clinical trials, especially at the beginning of treatment.
Extrapyramidal syndrome may be associated with this drug.[Ref]
Common (1% to 10%): Abdominal pain, nausea
Common (1% to 10%): Flushing
Common (1% to 10%): Fatigue
Uncommon (0.1% to 1%): Tinnitus, asthenia, pain, malaise
Frequency not reported: Rigors, thirst[Ref]
Very rare (less than 0.01%): Dysuria, polyuria
Frequency not reported: Male/female sexual dysfunction[Ref]
Uncommon (0.1% to 1%): Arthralgia, myalgia, muscle cramps, back pain
Very rare (less than 0.01%): Muscle weakness
Frequency not reported: Arthrosis, twitching[Ref]
Rare (0.01% to 0.1%): Confusion
Uncommon (0.1% to 1%): Dyspnea, rhinitis
Very rare (less than 0.01%): Cough
Frequency not reported: Epistaxis[Ref]
Uncommon (0.1% to 1%): Visual disturbance (including diplopia)
Very rare (less than 0.01%): Abnormal visual accommodation, xerophthalmia
Uncommon (0.1% to 1%): Weight increase/decrease
Very rare (less than 0.01%): Hyperglycemia, increased appetite
Frequency not reported: Anorexia[Ref]
Uncommon (0.1% to 1%): Purpura
Uncommon (0.1% to 1%): Gynecomastia[Ref]
Increased hepatic enzymes were mostly consistent with cholestasis.
Very rare (less than 0.01%): Hepatitis, jaundice, hepatic enzymes increased[Ref]
Frequently asked questions
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- How do I reduce swelling from amlodipine?
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More about amlodipine
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- Drug class: calcium channel blocking agents
Related treatment guides
1. "Product Information. Norvasc (amlodipine)." Pfizer U.S. Pharmaceuticals (2002):
2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
3. Cerner Multum, Inc. "Australian Product Information." O 0
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.