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Amlodipine Dosage

Applies to the following strength(s): 2.5 mg ; 5 mg ; 10 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Geriatric Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Hypertension

Initial dose: 5 mg orally once a day
Maintenance dose: 5 to 10 mg orally once a day
Maximum dose: 10 mg/day

Comments:
-Patients who are small or fragile may be started on 2.5 mg orally once a day.
-The dosage should be adjusted according to patient response. In general, titration should proceed over 7 to 14 days. If clinically warranted, titration may proceed more rapidly, provided the patient is assessed frequently.

Use:
-Alone or in combination with other antihypertensive agents to treat hypertension

Usual Adult Dose for Angina Pectoris

Maintenance dose: 5 to 10 mg orally once a day
Maximum dose: 10 mg/day

Comments:
-In clinical studies, most patients with angina or coronary artery disease (CAD) required 10 mg orally once a day.
-The dosage should be adjusted according to patient response. In general, titration should proceed over 7 to 14 days. If clinically warranted, titration may proceed more rapidly, provided the patient is assessed frequently.

Uses:
-Alone or in combination with other antianginal agents for the symptomatic treatment of chronic stable angina
-Alone or in combination with other antianginal agents for the treatment of confirmed/suspected vasospastic angina
-To reduce the risk of hospitalization for angina and to reduce the risk of a coronary revascularization procedure in patients with recently documented CAD by angiography and without heart failure or an ejection fraction less than 40%

Usual Adult Dose for Coronary Artery Disease

Maintenance dose: 5 to 10 mg orally once a day
Maximum dose: 10 mg/day

Comments:
-In clinical studies, most patients with angina or coronary artery disease (CAD) required 10 mg orally once a day.
-The dosage should be adjusted according to patient response. In general, titration should proceed over 7 to 14 days. If clinically warranted, titration may proceed more rapidly, provided the patient is assessed frequently.

Uses:
-Alone or in combination with other antianginal agents for the symptomatic treatment of chronic stable angina
-Alone or in combination with other antianginal agents for the treatment of confirmed/suspected vasospastic angina
-To reduce the risk of hospitalization for angina and to reduce the risk of a coronary revascularization procedure in patients with recently documented CAD by angiography and without heart failure or an ejection fraction less than 40%

Usual Geriatric Dose for Hypertension

Initial dose: 2.5 mg orally once a day
Maintenance dose: 2.5 to 10 mg orally once a day
Maximum dose: 10 mg/day

Comment:
-The dosage should be adjusted according to patient response. In general, titration should proceed over 7 to 14 days. If clinically warranted, titration may proceed more rapidly, provided the patient is assessed frequently.

Use:
-Alone or in combination with other antihypertensive agents to treat hypertension

Usual Geriatric Dose for Angina Pectoris

Initial dose: 5 mg orally once a day
Maintenance dose: 5 to 10 mg orally once a day
Maximum dose: 10 mg/day

Comments:
-In clinical studies, most patients with angina or coronary artery disease (CAD) required 10 mg orally once a day.
-The dosage should be adjusted according to patient response. In general, titration should proceed over 7 to 14 days. If clinically warranted, titration may proceed more rapidly, provided the patient is assessed frequently.

Uses:
-Alone or in combination with other antianginal agents for the symptomatic treatment of chronic stable angina
-Alone or in combination with other antianginal agents for the treatment of confirmed/suspected vasospastic angina
-To reduce the risk of hospitalization for angina and to reduce the risk of a coronary revascularization procedure in patients with recently documented CAD by angiography and without heart failure or an ejection fraction less than 40%

Usual Pediatric Dose for Hypertension

6 to 17 years:
-Maintenance dose: 2.5 to 5 mg orally once a day
-Maximum dose: 5 mg/day

Comments:
-Doses higher than 5 mg have not been studied in pediatric patients.
The dosage should be adjusted according to patient response. In general, titration should proceed over 7 to 14 days. If clinically warranted, titration may proceed more rapidly, provided the patient is assessed frequently.

Use:
-Alone or in combination with other antihypertensive agents to treat hypertension

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Hypertension:
-Initial dose: 2.5 mg orally once a day

Angina pectoris/coronary artery disease (CAD):
-Initial dose: 5 mg orally once a day

Comments:
-Most patients with angina or CAD will require a dosage of 10 mg/day.
-The dosage should be adjusted according to patient response. In general, titration should proceed over 7 to 14 days. If clinically warranted, titration may proceed more rapidly, provided the patient is assessed frequently.

Dose Adjustments

Patients using other concomitant antihypertensive drugs:
-Recommended initial dose: 2.5 mg orally once a day

Precautions

Safety and efficacy have not been established in patients younger than 6 years.

Consult WARNINGS section for additional precautions.

Dialysis

No adjustment recommended.

Other Comments

Administration advice:
-The oral tablet formulation may be taken with or without food.
-The oral solution should not be shaken or mixed with food/beverages prior to administration.

Storage requirements:
-The manufacturer product information should be consulted.

General:
-The oral solution formulation contains glycerol, which could result in upset stomach, headache, and/or diarrhea.
-This drug has been used safely in patients with chronic obstructive pulmonary disease, well-compensated heart failure, peripheral vascular disease, diabetes mellitus, and with abnormal lipid profiles.
-The magnitude of blood pressure reduction is correlated with the height of pretreatment elevation (e.g., patients with moderate hypertension had a 50% greater response in than patients with mild hypertension).

Monitoring:
-Blood pressure
-Periodic liver function tests

Patient advice:
-Inform patients that this drug may cause drowsiness, dizziness, headache, or nausea, and they should avoid driving or operating machinery until the full effects of the drug are seen.
-Instruct patients to immediately report any signs/symptoms of Stevens-Johnson syndrome, hepatitis/jaundice, or hypersensitivity reactions.
-Patients should be advised to speak to a healthcare provider if they become pregnant, intend to become pregnant, or are breastfeeding.
-Patients should be advised to report all concurrent prescription and nonprescription medications or herbal products they are taking.

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