Skip to Content

Amlodipine: 6 things you should know

Medically reviewed by C. Fookes, BPharm Last updated on Nov 2, 2018.

1. How it works

  • Amlodipine may be used to treat heart conditions such as angina and high blood pressure.
  • Amlodipine inhibits the influx of calcium ions across cardiac (heart) and smooth muscle causing relaxation of these muscles and dilation (widening). The exact way amlodipine works in angina is not known; however, experts believe it helps prevent spasm of the coronary artery and reduces how hard the heart has to work to pump blood around the body, lowering its oxygen requirements. Amlodipine does not change the levels of calcium in the blood.
  • Amlodipine belongs to a class of medicines called calcium channel blockers (sometimes called calcium channel antagonists).

2. Upsides

  • May be used for the treatment of high blood pressure (hypertension), alone or in combination with other agents for high blood pressure.
  • May be used as an ongoing treatment to relieve symptoms such as chest pain in people with chronic stable angina, or angina due to coronary artery spasm. Will not relieve acute episodes of angina (other medications such as sublingual nitroglycerin are used for this purpose).
  • In African Americans, calcium channel blockers such as amlodipine may be recommended over other types of heart medications (for example ACE inhibitors, ARBs) for the treatment of hypertension.
  • Appears to have little or no interaction with grapefruit or grapefruit products or antacids.
  • Can improve a person's tolerance to exercise and keep their blood pressure at acceptable levels during exercise. Heart rate at maximal exercise does not change or is slightly reduced.
  • Generic amlodipine is available.

3. Downsides

If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:

  • Edema (swelling around the ankles) is the main side effect. Shortness of breath, dizziness, fast or irregular heart beat, flushing, and wheezing have also been reported.
  • Lower doses may be needed in patients with liver disease.
  • Rarely, excessively low blood pressure may be experienced by some people. The risk is higher for people with severe aortic stenosis.
  • Rarely, some patients may experience an increase in the frequency or severity of angina or acute myocardial infarction (heart attack) when starting amlodipine. The risk is greater in those with severe obstructive coronary artery disease.
  • May interact with a number of other drugs including those that inhibit hepatic enzymes CYP3A and other drugs that also lower blood pressure. See prescribing information for a full list of drug interactions.

Notes: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. For a complete list of all side effects, click here.

4. Bottom Line

Amlodipine may be used for the treatment of angina or to lower blood pressure but can cause edema in the feet.

5. Tips

  • May be taken with or without food.
  • The manufacturer states that there is no concern about taking amlodipine with grapefruit juice.
  • Be careful when going from sitting to standing as blood pressure may drop.
  • Report to your doctor any signs of dizziness, tiredness, flushing, nausea, indigestion, shortness of breath, excessive weight gain, muscle rigidity or tremors, or edema.
  • Dial 911 or report to an emergency department if wheezing, facial swelling, chest tightness, cough, or seizures occur suddenly.
  • Do not stop taking amlodipine suddenly. Although no "rebound" effect has been reported, it is better to slowly decrease the dosage over a period of time.
  • Your doctor may advise you to take sublingual nitroglycerin for any break-through angina pain.

6. Response and Effectiveness

  • Peak concentrations of amlodipine occur between 6 and 12 hours of an oral dose. The effect of amlodipine lasts for approximately 24 hours.


Amlodipine [Package Insert]. Revised 05/2018. Teva Pharmaceuticals USA, Inc.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use amlodipine only for the indication prescribed.

Copyright 1996-2019 Revision date: November 2, 2018.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.