Rimegepant Side Effects

Medically reviewed by Philip Thornton, DipPharm. Last updated on Mar 17, 2025.

Applies to rimegepant: oral tablet disintegrating.

Precautions

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to use it.

Check with your doctor if you used this medicine and it did not work. Also, check with your doctor if your migraine headaches are worse or if they are occurring more often since you started using this medicine.

This medicine may cause serious allergic reactions and may require immediate medical attention. Call your doctor right away if you have a rash, hives, fever, trouble breathing or swallowing, nausea, unusual tiredness or weakness, or any reddening or swelling of your eyes, face, or mouth while you are using this medicine.

Using rimegepant alone or in combination with other migraine medicines for 15 or more days per month may lead to worsening of headache. You may keep a headache diary to record your headache frequency and drug use.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of rimegepant

Along with its needed effects, rimegepant may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking rimegepant:

For healthcare professionals

Applies to rimegepant: oral tablet disintegrating.

General adverse events

The most common adverse reaction was nausea for both acute use and preventive use.^[Ref]

Gastrointestinal

• Common (1% to 10%): Nausea, abdominal pain/dyspepsia^[Ref]

Abdominal pain/dyspepsia includes epigastric discomfort, gastro-esophageal reflux disease, abdominal tenderness, abdominal distention, and low and upper abdominal pain.^[Ref]

Genitourinary

• Common (1% to 10%): Urinary tract infection

Hypersensitivity

• Uncommon (0.1% to 1%): Hypersensitivity reactions (including dyspnea and severe rash)^[Ref]

Respiratory

• Common (1% to 10%): Nasopharyngitis, upper respiratory tract infection, sinusitis

See also:

Frequently asked questions

• How do Ubrelvy, Qulipta and Nurtec compare for migraines?
• What are the new drugs for the treatment of migraine?
• How fast and effective is Nurtec ODT for migraines?
• How often can you take Nurtec ODT?
• Does Nurtec ODT cause weight gain?
• What is the mechanism of action for Nurtec ODT?
• Nurtec coupon: Do I qualify and how much can I save?

Further information

Rimegepant side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer