Rimegepant Dosage

Medically reviewed by Drugs.com. Last updated on Mar 21, 2025.

Usual Adult Dose for Migraine

75 mg orally as needed
Maximum dose: 75 mg in 24 hours

Comments:

• The safety of taking more than 18 doses in a 30-day period is unknown.

Use: For the acute treatment of migraine with or without aura

Usual Adult Dose for Migraine Prophylaxis

75 mg orally every other day

Use: For the preventative treatment of episodic migraine

Renal Dose Adjustments

Mild to Severe Renal Dysfunction (CrCl 15 mL/min or greater): No adjustment recommended
End Stage Renal Disease (CrCl less than 15 mL/min): Avoid use

Liver Dose Adjustments

Mild to Moderate Liver dysfunction (Child-Pugh A or B): No adjustment recommended
Severe Liver dysfunction (Child-Pugh C): Avoid use

Dose Adjustments

Concomitant Use with CYP450 3A4 Inhibitors:

• Strong CYP450 3A4 inhibitors: Avoid concomitant administration.
• Moderate CYP450 3A4 inhibitors: Avoid a second dose of this drug within 48 hours.

Concomitant Use with CYP450 3A4 Inducers:

• Strong or moderate CYP450 3A4 inducers: Avoid concomitant administration as this may lead to loss of efficacy of this drug

Concomitant Use with P-gp (P-glycoprotein):

• Potent P-gp inhibitors: Avoid a second dose of this drug within 48 hours.

Precautions

CONTRAINDICATIONS:

• History of hypersensitivity reaction to this drug (or any of its formulations), or any of its components; delayed serious hypersensitivity has occurred

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

• Advise patients not to remove the blister from the outer aluminum pouch until ready to take the drug. Hands should be dry when opening the blister pack.
• Instruct the patient to peel back the foil covering the blister and gently remove the orally disintegrated tablet (ODT). The tablet should not be pushed through the foil. Take immediately and do not store outside of the pack for future use.
• The tablet should be placed on or under the tongue, allowing it to dissolve in the saliva, and be swallowed without additional liquid.
• Advise patients not to take more than one dose in a day.
• Discuss signs and symptoms of hypersensitivity reactions with patients and inform them that it can occur days after administration.

Storage requirements:

• Store at room temperature, 20C to 25C (68F to 77F); with excursions permitted between 15C to 30C (59F to 86F).

Patient advice:

• Read the US FDA-approved patient labeling (Patient Information).
• Contact your healthcare provider immediately if you experience signs or symptoms of hypersensitivity reaction.
• Speak with your healthcare provider about all other medicines you are taking including over-the-counter medications and herbal supplements.
• Speak with your healthcare provider if you become pregnant or plan to become pregnant, are breastfeeding, or plan to breastfeed during therapy.

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See also:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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