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Pronunciation: you-brel-vee
Generic name: ubrogepant
Dosage form: 50mg tablet, 100mg tablet
Drug class: CGRP inhibitors

Medically reviewed by Melisa Puckey, BPharm. Last updated on Jan 18, 2024.

What is Ubrelvy?

Ubrelvy tablets are used to treat migraine headaches in adults, that are with or without aura. Ubrelvy works by blocking a protein called CGRP in the nerve endings that are involved in pain and migraines, this helps reduce pain and migraine symptoms. Ubrelvy is from the CGRP inhibitor class of medicines and is a prescription medicine.

Ubrelvy is used when you have a migraine headache, it is not used to prevent a migraine headache.

Ubrelvy (ubrogepant) received FDA approval on December 23, 2019, for the acute treatment of migraine with or without aura in adults. They are available as Ubrelvy 100mg tablets and Ubrelvy 50mg tablets.

Ubrelvy side effects

Common Ubrelvy side effects may include nausea or sleepiness.

Serious Ubrelvy side effects Get emergency medical help if you have signs of an allergic reaction to Ubrelvy: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


You should not take Ubrelvy if you are taking medicines known as strong CYP3A4 Inhibitors, such as:

Ask your healthcare provider if you are not sure if you are taking any of these medicines. Your healthcare provider can tell you if it is safe to take Ubrelvy with other medicines.

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.

Before taking this medicine

Many drugs can interact and cause dangerous effects. Some drugs should not be used together with Ubrelvy. Your doctor may change your treatment plan if you also use:

To make sure this medicine is safe for you, tell your doctor if you have:

Ubrelvy is not approved for use by anyone younger than 18 years old.


Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether Ubrelvy will harm an unborn baby. However, having migraine headaches during pregnancy may cause complications such as diabetes or eclampsia (dangerously high blood pressure that can lead to medical problems in both mother and baby). The benefit of treating migraines may outweigh any risks to the baby.


It may not be safe to breastfeed while using this medicine. Ask your doctor about any risks.

How should I take Ubrelvy?

Take Ubrelvy exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

You may take this medicine with or without food. Avoid grapefruit or grapefruit juice.

After taking Ubrelvy: If your headache does not completely go away or goes away and comes back, you may take a second tablet if it has been at least 2 hours since your first dose. If your symptoms have not improved, contact your doctor before taking any more tablets.

You should not take a second tablet within 24 hours if you have consumed a grapefruit product or if you also take any of the following medications:

Call your doctor if you have more than 8 headaches in one month (30 days). Tell your doctor if this medicine seems to stop working as well in treating your migraine attacks.

What is the cost of Ubrelvy?

The cost of prescription drugs varies depending on your insurance plan and which pharmacy you use. Refer to our Ubrelvy price guide page for more information about the cost.

You may also be eligible for a Ubrelvy savings card, Ubrelvy coupon or Ubrelvy copay card. Ask your doctor or pharmacist if you qualify.

Ubrelvy Dosing information

Usual Adult Dose for Migraine: Take 50 mg to 100 mg orally once, then after 2 hours, a second dose may be taken if needed.
Maximum dose: 200 mg in a 24-hour period

Comments: The safety of treating more than 8 migraines in a 30-day period is unknown.

What happens if I miss a dose?

Since Ubrelvy is used when needed, it does not have a daily dosing schedule. Do not take more than 200 milligrams in a 24-hour period. Do not use this medicine to treat more than 8 headaches per month.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What to avoid

Grapefruit may interact with ubrogepant and lead to unwanted side effects. You should not take a second Ubrelvy tablet within 24 hours after consuming grapefruit or grapefruit juice.

What other drugs will affect Ubrelvy?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Tell your doctor about all your current medicines. Many drugs can interact with Ubrelvy, especially:

This list is not complete and many Other drugs may interact with ubrogepant. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Ubrelvy Package Insert

Review the full Ubrelvy prescribing information here for more detailed information about this medicine. Discuss any medical questions you have with your doctor or other health care provider. This is not all the information you need to know about Ubrelvy for safe and effective use and does not take the place of talking to your doctor about your treatment.


Store at room temperature between 68ºF to 77ºF (20ºC to 25ºC).


Active ingredient: ubrogepant

Inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, mannitol, microcrystalline cellulose, polyvinylpyrrolidone vinyl acetate copolymer, sodium chloride, sodium stearyl fumarate, and vitamin E polyethylene glycol succinate.


Manufactured for: AbbVie Inc. North Chicago, IL 60064

Popular FAQ

Ubrelvy, Qulipta and Nurtec ODT are all medicines used by adults for migraines. They are all from the same group of medicines often called gepants but their full name is calcitonin gene-related peptide (CGRP) receptor antagonist. Continue reading

Ubrelvy and Imitrex are both oral tablets used to treat migraine, but there are differences in the way they work. Ubrelvy prevents a protein called CGRP thought to play a role in migraine attacks from binding to its receptor and Imitrex is thought to bind to serotonin 5‑HT1B/1D receptors, and inhibit pro-inflammatory substances Although no head-to-head comparison trials compare Ubrelvy to Imitrex, indirect evidence suggests that overall, Ubrelvy is no more effective, and may be inferior to Imitrex at relieving migraine in adults who are able to tolerate triptans. For those adults with moderate-to-severe migraine attacks that cannot tolerate triptans or who have found them ineffective, Ubrelvy is beneficial for treating migraines compared to no treatment. Ubrelvy is associated with fewer side effects than Imitrex, but is more expensive, costing almost twice as much. Continue reading

Some patients may not be able to use NSAIDs or triptans to treat acute migraine headaches due to side effects or health conditions. In these circumstances, newer agents like Ubrelvy (ubrogepant), a calcitonin gene-related peptide (CGRP) antagonist, may be an appropriate option. Continue reading

Rebound or medication overuse headache has not been reported to be an issue for people using Ubrelvy (ubrogepant) to treat their migraine headaches.

Ubrelvy belongs to a group of medications known as small molecule calcitonin gene-related peptide receptor antagonists or gepants. It is available in tablet form (50 and 100mg) and is taken orally.

Ubrelvy is used to treat migraine with or without aura and can be taken twice in a 24 hour period, up to a maximum of Ubrelvy 200mg per day. A minimum of 2 hours between doses is necessary. It’s not known whether it’s safe to use Ubrelvy for the treatment of more than 8 migraines in 30 days. Continue reading

Ubrelvy is not classified as a narcotic (opioid) and is not a controlled substance. Ubrelvy is a calcitonin gene-related peptide (CGRP) receptor antagonist that helps to relieve pain and inflammation associated with acute migraine headaches. Ubrelvy is not used for the prevention of migraine headaches. It is available in oral tablet form. Continue reading

No reports of clinically apparent liver injury were made during clinical development of Ubrelvy (ubrogepant) and none have been made since the drug’s launch in the US in 2019. Continue reading

The mechanism of action for Ubrelvy (generic name: ubrogepant) involves the blockade of a nerve protein called calcitonin gene-related peptide (CGRP) that contributes to migraine headache pain. Ubrelvy is used to treat an acute migraine, with or without auras, once it starts. It is not used to prevent a migraine. Continue reading

No, Ubrelvy is not a triptan, it belongs to the class of medicines known as CGRP inhibitors. CGRP stands for calcitonin gene-related peptide (CGRP) receptor antagonists (also known as gepants) and Ubrelvy works by preventing CGRP from attaching to CGRP receptors on nerve endings. CGRP is a protein that is thought to play a role in migraine attacks by causing pain, dilation of blood vessels, and inflammation. By preventing CGRP from binding to its receptor, Ubrelvy stops migraine pain and other symptoms. Continue reading

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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Ubrelvy only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.