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Medications for Migraine

Drugs associated with Migraine

The following drugs and medications are in some way related to, or used in the treatment of this condition.

What is Migraine: Migraine headaches are a type of headache that some people get repeatedly over time. Migraines are different from other headaches because they occur with symptoms such as nausea, vomiting, or sensitivity to light.

Some people who get migraines have warning symptoms, called an aura, before the actual headache begins. Most people, however, do not have such warning symptoms.

Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Popularity
sumatriptan Rx C N 221 reviews
8.0

Generic name: sumatriptan systemic

Brand names:  Imitrex, Imitrex Statdose, Sumavel DosePro, Imitrex Nasal, Alsuma, Onzetra Xsail, Zecuity, Zembrace SymTouch

Drug class: antimigraine agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Imitrex Rx C N 106 reviews
7.0

Generic name: sumatriptan systemic

Drug class: antimigraine agents

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Maxalt Rx C N 85 reviews
8.0

Generic name: rizatriptan systemic

Drug class: antimigraine agents

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Relpax Rx C N 110 reviews
8.0

Generic name: eletriptan systemic

Drug class: antimigraine agents

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Amerge Rx C N 19 reviews
9.0

Generic name: naratriptan systemic

Drug class: antimigraine agents

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Axert Rx C N 26 reviews
9.0

Generic name: almotriptan systemic

Drug class: antimigraine agents

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Butalbital Compound Rx C 3 X 8 reviews
8.0

Generic name: aspirin / butalbital / caffeine systemic

Drug class: analgesic combinations

For consumers: dosage, interactions, side effects

 
Treximet Rx C N X 79 reviews
9.0

Generic name: naproxen / sumatriptan systemic

Drug class: antimigraine agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Zomig Rx C N X 51 reviews
7.0

Generic name: zolmitriptan systemic

Drug class: antimigraine agents

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Maxalt-MLT Rx C N 52 reviews
9.0

Generic name: rizatriptan systemic

Drug class: antimigraine agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Cambia Rx D N X 20 reviews
8.0

Generic name: diclofenac systemic

Drug class: nonsteroidal anti-inflammatory agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Excedrin Migraine OTC N N X 63 reviews
7.0

Generic name: acetaminophen / aspirin / caffeine systemic

Drug class: analgesic combinations

For consumers: dosage, interactions, side effects

 
Fiorinal Rx C 3 X 38 reviews
8.0

Generic name: aspirin / butalbital / caffeine systemic

Drug class: analgesic combinations

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
gabapentin Off Label Rx C N X 67 reviews
8.0

Generic name: gabapentin systemic

Drug class: gamma-aminobutyric acid analogs

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
Frova Rx C N 32 reviews
9.0

Generic name: frovatriptan systemic

Drug class: antimigraine agents

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
rizatriptan Rx C N 176 reviews
9.0

Generic name: rizatriptan systemic

Brand names:  Maxalt, Maxalt-MLT

Drug class: antimigraine agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Reglan Rx B N X 37 reviews
4.0

Generic name: metoclopramide systemic

Drug class: GI stimulants, miscellaneous antiemetics

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
cyclobenzaprine Off Label Rx B N X 24 reviews
7.0

Generic name: cyclobenzaprine systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
aspirin / butalbital / caffeine Rx C 3 X 49 reviews
8.0

Generic name: aspirin / butalbital / caffeine systemic

Brand names:  Butalbital Compound, Fiorinal, Farbital

Drug class: analgesic combinations

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, Prescribing Information

 
Excedrin OTC N N X 11 reviews
7.0

Generic name: acetaminophen / aspirin / caffeine systemic

Drug class: analgesic combinations

For consumers: dosage, interactions, side effects

 
naratriptan Rx C N 27 reviews
8.0

Generic name: naratriptan systemic

Brand name:  Amerge

Drug class: antimigraine agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Norflex Off Label Rx C N X 1 review
4.0

Generic name: orphenadrine systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
Methergine Off Label Rx C N 6 reviews
8.0

Generic name: methylergonovine systemic

Drug class: uterotonic agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Off Label: Yes

 
Migranal Rx X N 14 reviews
7.0

Generic name: dihydroergotamine systemic

Drug class: antimigraine agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Botox Rx C N 7 reviews
7.0

Generic name: onabotulinumtoxinA systemic

Drug class: skeletal muscle relaxants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
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Topics under Migraine

Alternative treatments for Migraine

The following products are considered to be alternative treatments or natural remedies for Migraine. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However there may be historical, cultural or anecdotal evidence linking their use to the treatment of Migraine.

Learn more about Migraine

Legend

Off Label This medication may not be approved by the FDA for the treatment of this condition.
Prescription Only / Over the Counter
Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Pregnancy
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act Schedule
N The drug is not subject to the Controlled Substances Act.
1 The drug has a high potential for abuse. The drug has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use of the drug under medical supervision.
2 The drug has a high potential for abuse. The drug has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse of the drug may lead to severe psychological or physical dependence.
3 The drug has a potential for abuse less than the drugs in schedules 1 and 2. The drug has a currently accepted medical use in treatment in the United States. Abuse of the drug may lead to moderate or low physical dependence or high psychological dependence.
4 The drug has a low potential for abuse relative to the drugs in schedule 3. The drug has a currently accepted medical use in treatment in the United States. Abuse of the drug may lead to limited physical dependence or psychological dependence relative to the drugs in schedule 3.
5 The drug has a low potential for abuse relative to the drugs in schedule 4. The drug has a currently accepted medical use in treatment in the United States. Abuse of the drug may lead to limited physical dependence or psychological dependence relative to the drugs in schedule 4.
Alcohol
X Interacts with Alcohol.

Synonym(s): Basilar Artery Migraine; Basilar-Type Migraine; Complicated Migraine; Hemiplegic Migraine; Migraine Headache

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