Atogepant

Generic name: atogepant (a toe' je pant)
Brand name: Qulipta
Dosage form: Tablet (10 mg; 30 mg; 60mg)
Drug class: CGRP inhibitors

Medically reviewed by Melisa Puckey, BPharm. Last updated on Aug 23, 2023.

What is atogepant?

Atogepant (Qulipta) is a prescription medicine used for the preventive treatment of episodic migraine in adults. Atogepant is CGRP inhibitor (calcitonin gene-related peptide receptor antagonist) that works by blocking a small protein (CGRP) in the body that is involved with migraines and pain.

Atogepant has been shown in clinical trials to reduce the number of monthly migraines, the number of monthly headache days, and decrease the number of days patients had to take other medicines to treat migraines.

Atogepant is a once-a-day tablet that is FDA approved to prevent episodic migraine headaches in adults.

Before taking this medicine

Tell your healthcare provider about all of your medical conditions before you take atogepant, this includes if you:

have problems with your liver.
have problems with your kidneys or are on dialysis.
are planning to become pregnant or are pregnant, as it is not known if this medicine will harm your unborn baby.
are planning to breastfeed or are breastfeeding as it is not known if this medicine passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby while taking this medicine.
are allergic to atogepant, or any of the ingredients in atogepant tablets. A list of ingredients in Qulipta brand of atogepant is below.

How should I take atogepant?

Atogepant is a tablet that is taken by mouth (orally).
Atogepant is taken once daily, around the same time each day, it can be taken with or without food.
Atogepant is used to prevent migraines. You should take it every day, whether you feel well or have a migraine.
Take this medicine exactly as directed by your healthcare provider.
Do not stop taking atogepant without talking to your doctor.

Atogepant dosing information

Qulipta brand of atogepant is available as 10 mg, 30 mg, or 60 mg tablets.
The usual adult dose for preventive treatment of migraine is:

10 mg, 30 mg, or 60 mg taken orally once daily and can be taken with or without food.

The dose you are prescribed may depend on your kidney function and any other medications you take. See below “What other drugs will affect atogepant?”

What happens if I miss a dose?

If you miss a dose take your tablet as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What happens if I overdose?

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at Poison Help. If the victim has collapsed, has trouble breathing, had a seizure, or can't be awakened, immediately call emergency services at 911.

Atogepant side effects

Common atogepant side effects may include:

constipation,
nausea, and
fatigue.

This is not all of the possible side effects of atogepant. Talk with doctor, pharmacist or health professional for medical advice about side effects. Side effects may be reported to FDA at 1-800-FDA-1088.

What other drugs will affect atogepant?

Tell your doctor, pharmacist, or healthcare provider about any other prescription, over-the-counter medicines, vitamins, and nutritional supplements you are taking, planning to take, or if you are stopping or reducing the dose of these products.

Medications and other products may interact with atogepant. Your doctor may need to change the doses of your medications or monitor you carefully for side effects depending on what other products you are taking.

It is very important to tell your healthcare provider of any of these medications:

ketoconazole or itraconazole
cyclosporine
clarithromycin
rifampin
carbamazepine
phenytoin
St. John’s wort
efavirenz
etravirine

This is not a complete list of drug interactions with atogepant. Not all possible interactions are listed here.

How should I store atogepant?

atogepant should be stored at room temperature between 68ºF to 77ºF (20ºC to 25ºC).
Keep medicines out of the reach of children and pets.

What are the ingredients in atogepant?

Qulipta Brand

Active ingredient: atogepant
Inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, mannitol, microcrystalline cellulose, polyvinylpyrrolidone vinyl acetate copolymer, sodium chloride, sodium stearyl fumarate, and vitamin E polyethylene glycol succinate.