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Medications for Headache

Drugs associated with Headache

The following drugs and medications are in some way related to, or used in the treatment of this condition.

What is Headache: A headache is pain or discomfort in the head, scalp, or neck. Most headaches are due to tension, migraine, or a combination of the two. Serious underlying causes of headaches, like a tumor or a stroke, are extremely rare, despite the fact that many people worry about these possibilities.

Most people with headaches can feel much, much better by making lifestyle changes, including learning ways to relax, and occasionally by taking medications.

Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Popularity
Fioricet Rx C N X 105 reviews
8.0

Generic name: acetaminophen / butalbital / caffeine systemic

Drug class: analgesic combinations

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
ibuprofen Rx/OTC C N X 14 reviews
8.0

Generic name: ibuprofen systemic

Brand names:  Advil, Motrin, IBU, Advil Liqui-Gels, Advil Migraine, Motrin IB, A-G Profen, Ibu-6, Ibu-8, IBU-200, Nuprin, Proprinal, Actiprofen, Addaprin, Advil Children's, Genpril, Haltran, Ibu-4, Ibu-Tab, Midol IB, Q-Profen

Drug class: nonsteroidal anti-inflammatory agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Advil Rx/OTC C N X 2 reviews
9.0

Generic name: ibuprofen systemic

Drug class: nonsteroidal anti-inflammatory agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Butalbital Compound Rx C 3 X 2 reviews
8.0

Generic name: aspirin / butalbital / caffeine systemic

Drug class: analgesic combinations

For consumers: dosage, interactions, side effects

 
Fioricet with Codeine Rx C 3 X 14 reviews
9.0

Generic name: acetaminophen / butalbital / caffeine / codeine systemic

Drug class: narcotic analgesic combinations

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Midrin Rx N 4 X 46 reviews
8.0

Generic name: acetaminophen / dichloralphenazone / isometheptene mucate systemic

Drug class: antimigraine agents

For consumers: dosage, interactions, side effects

 
acetaminophen / butalbital / caffeine Rx C N X 158 reviews
8.0

Generic name: acetaminophen / butalbital / caffeine systemic

Brand names:  Fioricet, Esgic, Zebutal, Anolor 300, Capacet, Margesic, Vanatol LQ

Drug class: analgesic combinations

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, Prescribing Information

 
naproxen Rx/OTC C N X 24 reviews
8.0

Generic name: naproxen systemic

Brand names:  Aleve, Naprosyn, Anaprox, Naprelan, Anaprox-DS, Leader Naproxen Sodium, Aflaxen, All Day Pain Relief, All Day Relief, EC-Naprosyn, Flanax Pain Reliever, Midol Extended Relief

Drug class: nonsteroidal anti-inflammatory agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Aleve Rx/OTC C N X 5 reviews
7.0

Generic name: naproxen systemic

Drug class: nonsteroidal anti-inflammatory agents

For consumers: dosage, interactions, side effects

 
Fiorinal Rx C 3 X 16 reviews
9.0

Generic name: aspirin / butalbital / caffeine systemic

Drug class: analgesic combinations

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Naprosyn Rx/OTC C N X Add review
10

Generic name: naproxen systemic

Drug class: nonsteroidal anti-inflammatory agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Bupap Rx C N X 4 reviews
8.0

Generic name: acetaminophen / butalbital systemic

Drug class: analgesic combinations

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Motrin Rx/OTC C N X 3 reviews
9.0

Generic name: ibuprofen systemic

Drug class: nonsteroidal anti-inflammatory agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
aspirin / butalbital / caffeine Rx C 3 X 18 reviews
9.0

Generic name: aspirin / butalbital / caffeine systemic

Brand names:  Butalbital Compound, Fiorinal, Farbital

Drug class: analgesic combinations

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, Prescribing Information

 
Esgic Rx C N X 8 reviews
9.0

Generic name: acetaminophen / butalbital / caffeine systemic

Drug class: analgesic combinations

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Anaprox Rx/OTC C N X Add review Add

Generic name: naproxen systemic

Drug class: nonsteroidal anti-inflammatory agents

For consumers: dosage, interactions, side effects

 
Naprelan Rx/OTC C N X 1 review
10

Generic name: naproxen systemic

Drug class: nonsteroidal anti-inflammatory agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Tylenol PM Rx/OTC N N X 3 reviews
5.0

Generic name: acetaminophen / diphenhydramine systemic

Drug class: analgesic combinations

For consumers: dosage, interactions, side effects

 
IBU Rx/OTC C N X Add review
6.0

Generic name: ibuprofen systemic

Drug class: nonsteroidal anti-inflammatory agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
acetaminophen / butalbital Rx C N X 13 reviews
9.0

Generic name: acetaminophen / butalbital systemic

Brand names:  Bupap, Phrenilin, Tencon, Allzital, Axocet, Marten-Tab, Orbivan CF

Drug class: analgesic combinations

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, Prescribing Information

 
acetaminophen / dichloralphenazone / isometheptene mucate Rx N 4 X 58 reviews
8.0

Generic name: acetaminophen / dichloralphenazone / isometheptene mucate systemic

Brand names:  Midrin, Epidrin, Duradrin, LarkaDrin, Migragesic IDA, Nodolor

Drug class: antimigraine agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, Prescribing Information

 
Fiorinal with Codeine Rx C 3 X 10 reviews
9.0

Generic name: aspirin / butalbital / caffeine / codeine systemic

Drug class: narcotic analgesic combinations

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
trazodone Off Label Rx C N X 4 reviews
3.0

Generic name: trazodone systemic

Drug class: phenylpiperazine antidepressants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
Advil Liqui-Gels Rx/OTC C N X 1 review
7.0

Generic name: ibuprofen systemic

Drug class: nonsteroidal anti-inflammatory agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Percogesic Rx/OTC N N X 9 reviews
9.0

Generic name: acetaminophen / phenyltoloxamine systemic

Drug class: analgesic combinations

For consumers: dosage, interactions, side effects

 
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Topics under Headache

Alternative treatments for Headache

The following products are considered to be alternative treatments or natural remedies for Headache. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However there may be historical, cultural or anecdotal evidence linking their use to the treatment of Headache.

Learn more about Headache

Legend

Off Label This medication may not be approved by the FDA for the treatment of this condition.
Prescription Only / Over the Counter
Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Pregnancy
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act Schedule
N The drug is not subject to the Controlled Substances Act.
1 The drug has a high potential for abuse. The drug has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use of the drug under medical supervision.
2 The drug has a high potential for abuse. The drug has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse of the drug may lead to severe psychological or physical dependence.
3 The drug has a potential for abuse less than the drugs in schedules 1 and 2. The drug has a currently accepted medical use in treatment in the United States. Abuse of the drug may lead to moderate or low physical dependence or high psychological dependence.
4 The drug has a low potential for abuse relative to the drugs in schedule 3. The drug has a currently accepted medical use in treatment in the United States. Abuse of the drug may lead to limited physical dependence or psychological dependence relative to the drugs in schedule 3.
5 The drug has a low potential for abuse relative to the drugs in schedule 4. The drug has a currently accepted medical use in treatment in the United States. Abuse of the drug may lead to limited physical dependence or psychological dependence relative to the drugs in schedule 4.
Alcohol
X Interacts with Alcohol.

Synonym(s): Tension Headache

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