Generic Name: meclofenamate (MEK loe FEN a mate)
Brand Name: Meclomen
Medically reviewed on July 23, 2018
What is meclofenamate?
Meclofenamate is a nonsteroidal anti-inflammatory drug (NSAID). Meclofenamate works by reducing hormones that cause inflammation and pain in the body.
Meclofenamate is used to treat fever or mild to moderate pain in adults. Meclofenamate is also used to relieve symptoms of osteoarthritis or rheumatoid arthritis in adults, and juvenile arthritis in children who are at least 14 years old.
Meclofenamate is also used to treat menstrual pain or heavy menstrual bleeding.
Meclofenamate may also be used for purposes not listed in this medication guide.
Meclofenamate can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Do not use meclofenamate just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
Meclofenamate may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using meclofenamate, especially in older adults.
Before taking this medicine
Meclofenamate may increase your risk of heart attack or stroke, especially if you use it long term or have heart disease. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
Meclofenamate may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using meclofenamate.
To make sure meclofenamate is safe for you, tell your doctor if you have:
a history of heart attack, stroke, or blood clot;
a history of stomach ulcers or bleeding;
liver or kidney disease;
Taking meclofenamate during the last 3 months of pregnancy may harm the unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It is not known whether meclofenamate passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.
Meclofenamate is not approved for use by anyone younger than 14 years old.
How should I take meclofenamate?
Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take meclofenamate in larger amounts or for longer than recommended. Use the lowest dose that is effective in treating your condition.
Do not take more than 400 milligrams (mg) of meclofenamate in one day.
If you use this medicine long-term, you may need frequent medical tests at your doctor's office.
Store at room temperature, away from moisture, heat, and light.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include decreased urination, confusion, behavior changes, agitation, or seizure (convulsions).
What should I avoid while taking meclofenamate?
Ask a doctor or pharmacist before using any cold, allergy, or pain medication. Many medicines available over the counter contain aspirin or other medicines similar to meclofenamate. Taking certain products together can cause you to get too much of this type of medication. Check the label to see if a medicine contains aspirin, ibuprofen, ketoprofen, or naproxen.
Avoid taking aspirin while you are taking meclofenamate.
Avoid drinking alcohol. It may increase your risk of stomach bleeding.
Meclofenamate side effects
Get emergency medical help if you have signs of an allergic reaction: sneezing, runny or stuffy nose; wheezing or trouble breathing; hives; swelling of your face, lips, tongue, or throat.
Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath.
Stop using meclofenamate and call your doctor at once if you have:
the first sign of any skin rash, no matter how mild;
shortness of breath (even with mild exertion);
swelling or rapid weight gain;
signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
kidney problems--little or no urinating, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath;
low red blood cells (anemia)--pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; or
severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Older adults may be more likely to have symptoms of stomach bleeding.
Common side effects may include:
nausea, stomach pain; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect meclofenamate?
Ask your doctor before using meclofenamate if you take an antidepressant such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone. Taking any of these medicines with an NSAID may cause you to bruise or bleed easily.
Tell your doctor about all your current medicines and any you start or stop using, especially:
heart or blood pressure medication, including a diuretic or "water pill"; or
steroid medicine (such as prednisone).
This list is not complete. Other drugs may interact with meclofenamate, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2018 Cerner Multum, Inc. Version: 2.02.
More about meclofenamate
- Meclofenamate Side Effects
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- Dosage Information
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- Drug class: Nonsteroidal anti-inflammatory drugs