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Medications for Rheumatoid Arthritis

Other names: Arthritis; Arthritis, Rheumatoid; RA

What is Rheumatoid Arthritis:  Rheumatoid arthritis is a chronic (long-term) inflammatory disease that primarily affects the joints and surrounding tissues, but can also affect other organ systems.

Medications to treat Rheumatoid Arthritis

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Popularity
methotrexate X N X 73 reviews
7.0

Generic name: methotrexate systemic

Brand names:  Rasuvo, Rheumatrex Dose Pack, Trexall, Otrexup

Drug class: antimetabolites, antirheumatics, antipsoriatics, other immunosuppressants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Celebrex C N 17 reviews
8.0

Generic name: celecoxib systemic

Drug class: cox-2 inhibitors

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Plaquenil N N 39 reviews
6.0

Generic name: hydroxychloroquine systemic

Drug class: antirheumatics, antimalarial quinolines

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Enbrel B N 86 reviews
8.0

Generic name: etanercept systemic

Drug class: antirheumatics, TNF alfa inhibitors

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Humira B N 96 reviews
6.0

Generic name: adalimumab systemic

Drug class: antirheumatics, TNF alfa inhibitors

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Actemra C N 12 reviews
8.0

Generic name: tocilizumab systemic

Drug class: interleukin inhibitors

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
prednisone C N 32 reviews
8.0

Generic name: prednisone systemic

Brand name:  Rayos

Drug class: glucocorticoids

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
meloxicam C N X 33 reviews
6.0

Generic name: meloxicam systemic

Brand name:  Mobic

Drug class: nonsteroidal anti-inflammatory agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
hydroxychloroquine N N 75 reviews
6.0

Generic name: hydroxychloroquine systemic

Brand name:  Plaquenil

Drug class: antirheumatics, antimalarial quinolines

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Arava X N X 21 reviews
6.0

Generic name: leflunomide systemic

Drug class: antirheumatics, selective immunosuppressants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Remicade B N 26 reviews
8.0

Generic name: infliximab systemic

Drug class: antirheumatics, TNF alfa inhibitors

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
sulfasalazine B N 26 reviews
5.0

Generic name: sulfasalazine systemic

Brand names:  Sulfazine, Azulfidine, Azulfidine EN-tabs

Drug class: antirheumatics, 5-aminosalicylates

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Mobic C N X 18 reviews
6.0

Generic name: meloxicam systemic

Drug class: nonsteroidal anti-inflammatory agents

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Norco Off Label C 2 X 2 reviews
6.0

Generic name: acetaminophen / hydrocodone systemic

Drug class: narcotic analgesic combinations

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Off Label: Yes

 
Vicodin Off Label C 2 X 7 reviews
9.0

Generic name: acetaminophen / hydrocodone systemic

Drug class: narcotic analgesic combinations

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Off Label: Yes

 
Orencia C N 23 reviews
6.0

Generic name: abatacept systemic

Drug class: antirheumatics, selective immunosuppressants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Rituxan C N 9 reviews
7.0

Generic name: rituximab systemic

Drug class: antirheumatics, CD20 monoclonal antibodies

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
leflunomide X N X 40 reviews
6.0

Generic name: leflunomide systemic

Brand name:  Arava

Drug class: antirheumatics, selective immunosuppressants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
naproxen C N X 20 reviews
7.0

Generic name: naproxen systemic

Brand names:  Aleve, Naprosyn, Aflaxen, All Day Pain Relief, All Day Relief, Anaprox, Anaprox-DS, EC-Naprosyn, Flanax Pain Reliever, Midol Extended Relief, Naprelan

Drug class: nonsteroidal anti-inflammatory agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
acetaminophen / hydrocodone Off Label C 2 X 25 reviews
7.0

Generic name: acetaminophen / hydrocodone systemic

Brand names:  Norco, Vicodin, Lortab, Anexsia, Co-Gesic, Hycet, Liquicet, Lorcet 10 / 650, Lorcet Plus, Maxidone, Stagesic, Theracodophen Low 90, Vicodin ES, Vicodin HP, Xodol, Zamicet, Zolvit, Zydone

Drug class: narcotic analgesic combinations

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, Prescribing Information

Off Label: Yes

 
diclofenac D N X 30 reviews
7.0

Generic name: diclofenac systemic

Brand names:  Voltaren, Cataflam, Voltaren-XR

Drug class: nonsteroidal anti-inflammatory agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Sulfazine B N 4 reviews
4.0

Generic name: sulfasalazine systemic

Drug class: antirheumatics, 5-aminosalicylates

For consumers: dosage, interactions, side effects

 
Cimzia B N 5 reviews
8.0

Generic name: certolizumab systemic

Drug class: TNF alfa inhibitors

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Vimovo C N X 5 reviews
8.0

Generic name: esomeprazole / naproxen systemic

Drug class: nonsteroidal anti-inflammatory agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
ibuprofen C N X 5 reviews
8.0

Generic name: ibuprofen systemic

Brand names:  Advil, IBU, Motrin, A-G Profen, Actiprofen, Addaprin, Genpril, Haltran, Ibu-4, Ibu-6, Ibu-8, IBU-200, Ibu-Tab, Midol IB, Motrin IB, Nuprin, Proprinal, Q-Profen

Drug class: nonsteroidal anti-inflammatory agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
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Topics under Rheumatoid Arthritis

Alternative treatments for Rheumatoid Arthritis

The following products are considered to be alternative treatments or natural remedies for Rheumatoid Arthritis. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However there may be historical, cultural or anecdotal evidence linking their use to the treatment of Rheumatoid Arthritis.

Learn more about Rheumatoid Arthritis

Legend

Off Label This medication may not be approved by the FDA for the treatment of this condition.
Prescription Only / Over the Counter
Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Pregnancy
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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