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Medications for Rheumatoid Arthritis

Other names: Arthritis; Arthritis, Rheumatoid; RA

What is Rheumatoid Arthritis?

Rheumatoid arthritis is a long-term inflammatory condition that can affect the joints and other tissues and organs in the body.

What causes Rheumatoid Arthritis?

Rheumatoid arthritis (RA) is considered an autoimmune condition, which means it is caused by your immune system making antibodies which attack your tissue.

Experts are not sure why the immune system in some people does this, but they have identified certain risk factors that make some people more likely than others to develop RA. These include:

  • Smoking
  • Hormones: Women are more likely to develop RA than men
  • Having a family history of RA: Some evidence that RA can run in families

Some research suggests triggers, such as infection, trauma, or injury may kick off RA; however, none of these have been proven.

What are the symptoms of Rheumatoid Arthritis?

The main symptoms of RA are joint pain, swelling, and stiffness. Usually, symptoms develop gradually over several weeks, but in some people, symptoms develop rapidly.

The small joints of the hand and feet (such as the wrists, fingers, knees, toes, and ankles) are usually the first to become affected. Stiffness is usually worse first thing in the morning or after periods of inactivity and may make movement difficult. RA usually affects the joints on both sides of the body equally.

The pain is typically described as throbbing and aching. Joint stiffness is usually worse in the morning but still tends to persist, unlike stiffness caused by osteoarthritis which tends to wear off after about 30 minutes. Because the tissue inside the joints is affected, joints may look swollen and feel hot and tender to the touch. Some people develop firm swellings under the skin, called nodules,  around affected joints.
Joint and bone destruction can occur over time if the disease process is not well-controlled.

Patients may also lack energy and have experience fevers, sweating, a poor appetite, and weight loss. Other symptoms may occur depending on what other parts of the body are affected, for example, dry eyes, or heart or lung problems.

How is Rheumatoid arthritis diagnosed?

If you develop any symptoms suggestive of RA, see your doctor. Your doctor will complete a physical exam checking your joints for warmth or redness, and also check your reflexes and joint strength.

Other tests that may be conducted include:

  • Blood tests
  • C-reactive protein (CRC)
  • Rheumatoid Factor test
  • X-rays
  • An MRI.

How is Rheumatoid Arthritis treated?

Rheumatoid arthritis usually requires lifelong treatment with:

  • Medications
  • Physical therapy
  • Targeted home exercises
  • Health education
  • Possibly surgery.


Early, aggressive treatment of rheumatoid arthritis can delay joint destruction. 

Drugs Used to Treat Rheumatoid Arthritis

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Activity
Gordogesic N N Add review 0.0

Generic name: methyl salicylate topical

Drug class: topical rubefacient

For consumers: interactions, side effects

H.P. Acthar Gel C N Add review 0.0

Generic name: corticotropin systemic

Drug class: corticotropin

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Hadlima B N Add review 0.0

Generic name: adalimumab systemic

Drug class: TNF alfa inhibitors

For consumers: dosage, interactions, side effects

Hycet Off Label C 2 X Add review 0.0

Generic name: acetaminophen / hydrocodone systemic

Drug class: narcotic analgesic combinations

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Off Label: Yes

Hyrimoz B N Add review 0.0

Generic name: adalimumab systemic

Drug class: TNF alfa inhibitors

For consumers: dosage, interactions, side effects

Inflectra B N Add review 0.0

Generic name: infliximab systemic

Drug class: TNF alfa inhibitors

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

interferon gamma-1b Off Label C N Add review 0.0

Generic name: interferon gamma-1b systemic

Drug class: interferons

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph

Off Label: Yes

Ixifi B N Add review 0.0

Generic name: infliximab systemic

Drug class: TNF alfa inhibitors

For consumers: dosage, interactions, side effects

Lorcet Plus Off Label C 2 X Add review 0.0

Generic name: acetaminophen / hydrocodone systemic

Drug class: narcotic analgesic combinations

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Off Label: Yes

meclofenamate N N X Add review 0.0

Generic name: meclofenamate systemic

Drug class: Nonsteroidal anti-inflammatory drugs

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Mentholatum Deep Heating N N Add review 0.0

Generic name: methyl salicylate topical

Drug class: topical rubefacient

For consumers: interactions, side effects

methyl salicylate N N 7 reviews 6.8

Generic name: methyl salicylate topical

Brand names:  Analgesic Balm Greaseless, Arthricare Cream, Boroleum, Castiva Cooling, Eucalyptamint, Exocaine Plus, Flex-All 454 Maximum Strength, Gordogesic, Mentholatum Deep Heating, Salonpas Pain Patch, Satogesic …show all

Drug class: topical rubefacient

For consumers: interactions,

Myoflex N N Add review 0.0

Generic name: trolamine salicylate topical

Drug class: topical rubefacient

For consumers: dosage, side effects

Nalfon D N X Add review 0.0

Generic name: fenoprofen systemic

Drug class: Nonsteroidal anti-inflammatory drugs

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Neoral C N Add review 0.0

Generic name: cyclosporine systemic

Drug class: calcineurin inhibitors

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

penicillamine D N Add review 0.0

Generic name: penicillamine systemic

Brand names:  Cuprimine, D-Penamine, Depen, Depen Titratabs …show all

Drug class: antirheumatics

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Renflexis B N Add review 0.0

Generic name: infliximab systemic

Drug class: TNF alfa inhibitors

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Rinvoq N 11 reviews 6.7

Generic name: upadacitinib systemic

Drug class: antirheumatics

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Salonpas Pain Patch N N 5 reviews 6.0

Generic name: methyl salicylate topical

Drug class: topical rubefacient

For consumers: interactions, side effects

Satogesic N N Add review 0.0

Generic name: methyl salicylate topical

Drug class: topical rubefacient

For consumers: interactions, side effects

tetracycline Off Label D N Add review 0.0

Generic name: tetracycline systemic

Drug class: tetracyclines

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

Theracodophen Low 90 Off Label C 2 X Add review 0.0

Generic name: acetaminophen / hydrocodone systemic

Drug class: narcotic analgesic combinations

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Off Label: Yes

tolmetin C N X 1 review 9.0

Generic name: tolmetin systemic

Drug class: Nonsteroidal anti-inflammatory drugs

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

trolamine salicylate N N 3 reviews 4.0

Generic name: trolamine salicylate topical

Brand names:  Arthricream, Asper-Flex, Myoflex

Drug class: topical rubefacient

For consumers: dosage,

upadacitinib N 11 reviews 6.7

Generic name: upadacitinib systemic

Brand name:  Rinvoq

Drug class: antirheumatics

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph

Topics under Rheumatoid Arthritis

Alternative treatments for Rheumatoid Arthritis

The following products are considered to be alternative treatments or natural remedies for Rheumatoid Arthritis. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However there may be historical, cultural or anecdotal evidence linking their use to the treatment of Rheumatoid Arthritis.

Learn more about Rheumatoid Arthritis

IBM Watson Micromedex

Symptom checker

Symptoms and treatments

Drugs.com Health Center

Mayo Clinic Reference

ICD-10 CM Clinical Codes (External)

Legend

Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Off Label This medication may not be approved by the FDA for the treatment of this condition.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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Further information

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