Yuflyma Side Effects
Generic name: adalimumab
Medically reviewed by Drugs.com. Last updated on Apr 9, 2025.
Note: This document provides detailed information about Yuflyma Side Effects associated with adalimumab. Some dosage forms listed on this page may not apply specifically to the brand name Yuflyma.
Applies to adalimumab: subcutaneous solution.
Important warnings
This medicine can cause some serious health issues
Precautions
If you will be using this medicine for a long time, it is very important that your doctor check your or your child's progress at regular visits. This will allow your doctor to see if this medicine is working properly and to decide whether you should continue to use it. Blood and urine tests may be needed to check for unwanted effects.
You or your child will need to have a skin test for tuberculosis before using this medicine. Tell your doctor if you or anyone in your home has ever had a positive reaction to a tuberculosis skin test.
Adalimumab can temporarily lower the number of white blood cells in your blood, which may increase the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding:
- If you can, avoid people with infections. Check with your doctor right away if you or your child think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.
- Check with your doctor right away if you or your child notice any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, or pinpoint red spots on your skin.
- Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Check with your medical doctor before having any dental work done.
- Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime.
- Be careful not to cut yourself when you are using sharp objects such as a safety razor or fingernail or toenail cutters.
- Avoid contact sports or other situations where bruising or injury could occur.
Do not take other medicines unless they have been discussed with your doctor. Using abatacept (Orencia®) or anakinra (Kineret®) together with this medicine may increase your risk of having serious side effects.
This medicine may cause other unwanted effects that may not occur until months or years after this medicine is used. A small number of people (including children and teenagers) who have used this type of medicine have developed certain types of cancer (eg, leukemia). Some patients also developed a rare type of cancer called lymphoma. Talk with your doctor if you or your child have unusual bleeding, bruising, or weakness, swollen lymph nodes in the neck, underarms, or groin, or unexplained weight loss. Also, check with your doctor right away if your or your child's skin has red, scaly patches, or raised bumps that are filled with pus.
Adalimumab may cause serious allergic reactions (eg, anaphylaxis and angioneurotic edema), which can be life-threatening and requires immediate medical attention. Check with your doctor right away if you or your child have a cough, difficulty swallowing, dizziness, fast heartbeat, large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs, rash, itching, trouble breathing, or unusual tiredness or weakness after you receive the medicine.
Check with your doctor right away if you or your child has swelling of the face, fingers, feet, or lower legs, or sudden weight gain. These may be signs of a heart condition called congestive heart failure (CHF).
Some people who have used this medicine developed lupus-like symptoms during treatment and got better after the medicine was stopped. Check with your doctor right away if you or your child start having chest pains, joint pain, or a rash on the cheeks or arms that is sensitive to the sun.
Do not have any live vaccines (immunizations) while you or your child are being treated with adalimumab (the active ingredient contained in Yuflyma) Your child's vaccines need to be current before using adalimumab. Be sure to ask your child's doctor if you have any questions about this.
The needle cover of some prefilled syringes and pens contain dry natural rubber (a derivative of latex), which may cause allergic reactions in people who are sensitive to latex. Tell your doctor if you or your child have a latex allergy before using this medicine.
Serious skin reactions can occur during treatment with this medicine. Check with your doctor right away if you or your child has blistering, peeling, or loosening of the skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills while using this medicine.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Serious side effects of Yuflyma
Along with its needed effects, adalimumab may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking adalimumab:
More common side effects
- body aches or pain
- cough
- ear congestion
- gas with stomach pain
- hoarseness
- lightheadedness
- loss of voice
- lower back or side pain
- muscle aches and pains
- pain or tenderness around the eyes or cheekbones
- rapid and sometimes shallow breathing
- shivering
- stomach fullness
- stuffy nose
- sunken eyes
- thirst
- trouble sleeping
- warmth on the skin
- wrinkled skin
Less common side effects
- abnormal vaginal bleeding or discharge
- agitation
- arm, back, or jaw pain
- black, tarry stools
- bleeding from the gums or nose
- blindness
- bloating or swelling of the face, arms, hands, lower legs, or feet
- blood in the stool or change in bowel habits
- bloody or cloudy urine
- blurred vision
- broken bones
- change in size, shape, or color of an existing mole
- change in skin color
- chest pain, tightness, or heaviness
- chills
- clear or bloody discharge from the nipple
- cold hands and feet
- confusion
- constipation
- cough
- coughing or spitting up blood
- decreased urination
- decreased vision
- depression
- difficulty with breathing
- difficulty, burning, or painful urination
- dimpling of the breast skin
- dizziness
- drowsiness
- eye pain
- fainting
- fast, slow, or irregular heartbeat
- fever
- forgetfulness
- frequent urge to urinate
- general feeling of illness
- hair loss
- headache
- hives, itching, skin rash
- increased thirst
- inverted nipple
- irregular breathing
- irregular pulse
- irritability
- light colored stools
- loss of appetite
- lump in the breast or under your arm
- lump or swelling in the stomach
- mole that leaks fluid or bleeds
- muscle cramps or spasms
- nausea
- new mole
- night sweats
- no blood pressure or pulse
- noisy breathing
- numbness or tingling in your arms, legs, or face
- pain, redness, or swelling in the arms or legs without any injury present
- pale skin
- persistent non-healing sore on your skin
- pink growth
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- raised, firm, or bright red patch
- redness or swelling of the breast
- seeing or hearing things that are not there
- seizures
- sharp back pain just below your ribs
- shiny bump on your skin
- slurred speech or problems with swallowing
- sneezing
- sore on the skin of the breast that does not heal
- sore throat
- sores, ulcers, or white spots on the lips or mouth
- spitting up blood
- stiff neck
- stomach pain
- stopping of the heart
- sudden high fever or low grade fever for months
- sweating
- swelling of the face, fingers, feet, or lower legs
- swollen glands
- swollen neck veins
- tiredness
- trouble breathing
- trouble thinking
- unconsciousness
- unexplained bruising or bleeding
- unpleasant breath odor
- unusual tiredness or weakness
- unusual weight gain or loss
- visual disturbances
- vomiting
- vomiting of blood or material that looks like coffee grounds
- yellow skin or eyes
Incidence not known
- blistering, peeling, or loosening of the skin
- diarrhea
- inability to move the arms and legs
- joint or muscle pain
- pinpoint red spots on the skin
- red skin lesions, often with a purple center
- red, irritated eyes
- red, scaling, or crusted skin
- sudden numbness and weakness in the arms and legs
- unusual bleeding or bruising
Other side effects of Yuflyma
Some side effects of adalimumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common side effects
- bladder pain
- bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
- pounding in the ears
Less common side effects
- abnormal healing
- decrease in height
- difficulty with moving
- difficulty with walking
- dry mouth
- heartburn
- indigestion
- loss of hearing
- loss of strength or energy
- menstrual changes
- muscle or joint stiffness, tightness, or rigidity
- muscle pain or weakness
- pain in the back, ribs, arms, or legs
- shakiness in the legs, arms, hands, and feet
- swelling or redness in the joints
For healthcare professionals
Applies to adalimumab: subcutaneous kit, subcutaneous solution.
Cardiovascular adverse events
- Common (1% to 10%): Hypertension
- Uncommon (0.1% to 1%): Arrhythmia, atrial fibrillation, chest pain, coronary artery disorder, heart arrest, hypertensive encephalopathy, myocardial infarct, palpitation, pericardial effusion, pericarditis, syncope, tachycardia, congestive heart failure, peripheral edema, systemic vasculitis, deep vein thrombosis
- Rare (less than 0.1%): Vascular occlusion, aortic stenosis, thrombophlebitis, aortic aneurysm[Ref]
Dermatologic
- Very common (10% or more): Rash (12%)
- Common (1% to 10%): Dermatitis, eczema, pruritus, cellulitis, urticaria, psoriasis, ecchymosis, increased bruising, purpura, erysipelas, cutaneous vasculitis, herpes zoster
- Postmarketing reports: Stevens Johnson Syndrome, cutaneous vasculitis, erythema multiforme, new or worsening psoriasis (all subtypes including pustular and palmoplantar), alopecia, erythema multiforme, panniculitis[Ref]
Endocrine
- Uncommon (0.1% to 1%): Parathyroid disorder[Ref]
Gastrointestinal
- Common (1% to 10%): Diarrhea, nausea, abdominal pain, vomiting, stomatitis, mouth ulceration
- Uncommon (0.1% to 1%): Cholecystitis, cholelithiasis, gastroenteritis, gastrointestinal hemorrhage, gastritis, dyspepsia, gastrointestinal disorder, gastrointestinal hemorrhage, rectal hemorrhage, abdominal bloating
- Rare (less than 0.1%): Esophagitis, intestinal stenosis, colitis, enteritis
- Frequency not reported: Diverticulitis, large bowel perforations including perforations associated with diverticulitis and appendiceal perforations associated with appendicitis, pancreatitis[Ref]
Genitourinary
- Common (1% to 10%): Urinary tract infection, hematuria
- Uncommon (0.1% to 1%): Cystitis, kidney calculus, menstrual disorder, pyelonephritis[Ref]
Hematologic
- Common (1% to 10%): Lymphopenia, agranulocytosis, granulocytopenia, leucopenia, thrombocytopenia, anemia, lymphadenopathy, leukocytosis
- Rare (less than 0.1%): Pancytopenia, polycythemia, idiopathic thrombocytopenia purpura, lymphoma-like reaction, leg thrombosis, hypertriglyceridemia[Ref]
Hepatic
- Uncommon (0.1% to 1%): Liver failure, hepatitis
- Rare (less than 0.1%): Hepatic enzymes increased, hepatic necrosis
- Postmarketing reports: Hepatic failure[Ref]
Hypersensitivity
- Frequency not reported: Anaphylaxis, angioneurotic edema[Ref]
Immunologic
- Common (1% to 10%): Flu syndrome
- Uncommon (0.1% to 1%): Sarcoidosis
- Frequency not reported: Development of autoantibodies[Ref]
Local
- Very common (10% or more): Injection site pain (12%)
- Common (1% to 10%): Injection site reaction[Ref]
Metabolic
- Common (1% to 10%): Hypercholesterolemia, hyperlipidemia
- Uncommon (0.1% to 1%): Dehydration, ketosis, paraproteinemia, increased alkaline phosphatase[Ref]
Musculoskeletal
- Common (1% to 10%): Back pain
- Uncommon (0.1% to 1%): Arthritis, bone disorder, bone fracture (not spontaneous), bone necrosis, joint disorder, muscle cramps, myasthenia, pyogenic arthritis, synovitis, tendon disorder, pelvic pain
- Rare (less than 0.1%): Rhabdomyolysis[Ref]
Nervous system
- Very common (10% or more): Headache (12%)
- Uncommon (0.1% to 1%): Confusion, paraesthesia, subdural hematoma, tremor, demyelinating disorders (e.g., optic neuritis, Guillain-Barre syndrome), cerebrovascular accident, multiple sclerosis,
- Very rare (less than 0.01%): Hypertrophic pachymeningitis[Ref]
Ocular
- Uncommon (0.1% to 1%): Optic neuritis, cataract[Ref]
Oncologic
- Uncommon (0.1% to 1%): Adenoma, Merkel Cell Carcinoma (neuroendocrine carcinoma of the skin)
- Rare (less than 0.1%): Skin papilloma, carcinomas (breast, gastrointestinal, skin, testicular), lymphoma, melanoma, cancer of the white blood cells (known as Hepatosplenic T-Cell Lymphoma or HSTCL), mostly in adolescents and young adults[Ref]
Other
- Very common (10% or more): Accidental injury (10%)
- Uncommon (0.1% to 1%): Pain in extremity, thorax pain
- Rare (less than 0.1%): Pyrexia
- Frequency not reported: Sepsis, pain in thorax, opportunistic infections, tuberculosis, histoplasmosis, abscess, joint infection, wound infection, superficial fungal infections[Ref]
Renal
- Frequency not reported: Renal pain, renal impairment[Ref]
Respiratory
- Very common (10% or more): Upper respiratory infection (17%), sinusitis (11%), pneumonia, pharyngitis, nasopharyngitis
- Uncommon (0.1% to 1%): Asthma, bronchospasm, dyspnea, lung function decreased, pleural effusion, interstitial lung disease (including pulmonary fibrosis), pulmonary embolism
- Frequency not reported: Cough, upper respiratory infection, pharyngeal edema, nasal congestion, pulmonary edema, pleural effusion, pleurisy[Ref]
Psychiatric
- Common (1% to 10%): Mood alterations (including depression), anxiety, insomnia[Ref]
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References
1. (2003) "Product Information. Humira (adalimumab)." Abbott Pharmaceutical
2. Cerner Multum, Inc. "UK Summary of Product Characteristics."
3. Cerner Multum, Inc. "Australian Product Information."
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Further information
Yuflyma side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.