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Pronunciation: tol-t-s
Generic name: ixekizumabIX-ee-KIZ-ue-mab ]
Dosage forms: Autoinjector (80 mg/mL), Prefilled Syringe (80 mg/mL)
Drug class: Interleukin inhibitors

Medically reviewed by Melisa Puckey, BPharm. Last updated on May 8, 2024.

What is Taltz?

Taltz injection is used to treat plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, and non-radiographic axial spondyloarthritis, which are all autoimmune disorders. Taltz works by reducing inflammation, which helps improve the symptoms of these conditions.   

Taltz is a monoclonal antibody that works by binding and neutralizing a naturally occurring protein called interleukin 17A (IL-17A).  This protein is involved in inflammation and how the immune system responds. When Taltz (ixekizumab) binds to the protein, inflammation is reduced, and this improves symptoms of plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, and non-radiographic axial spondyloarthritis. Taltz is called an interleukin inhibitor as it blocks and inhibits interleukin 17A

Taltz injection can be self-administered or given by a caregiver using the autoinjector or prefilled syringe.  

Who can use Taltz?

Taltz is FDA-approved to treat:

Taltz side effects

Common Taltz Effects 

Common Taltz side effects may include nausea, ear infection, cold symptoms such as stuffy nose, sneezing, sore throat, and also pain or redness where the medicine was injected,

Serious Taltz side effects

Allergic reaction: Immediately get emergency medical help if you have signs of an allergic reaction such as rash, chest tightness, or difficulty breathing. feeling like you might pass out, swelling of your face, eyelids, lips, mouth, tongue, or throat.

Taltz may cause other serious side effects

Call your doctor at once if you have:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Infections. This medicine affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, sweating, muscle pain, weight loss, skin sores, shortness of breath, cough with red or pink mucus, increased urination, or painful urination.

Tuberculosis. Your doctor may perform tests to make sure you do not have tuberculosis or other infections

Hypersensitivity. Serious hypersensitivity reactions can occur with this medicine. If an allergic reaction occurs discontinue treatment immediately and initiate appropriate therapy. Taltz injection is contraindicated in patients who have had previous serious hypersensitivity reaction to this medicine.

Immunization. You should not have live vaccines while being treated with this medicine.

Inflammatory bowel disease. Crohn's disease and ulcerative colitis, including exacerbations have occurred during treatment with this medicine. Patients should be monitored closely when this medicine is prescribed to patients with inflammatory bowel disease (IBD). If IBD develops and appropriate medical management should be started.

Before taking this medicine

You should not use this medicine if you are allergic to the active ingredient ixekizumab, or any of the inactive ingredients contained in this medicine. To check for a complete list of ingredients, see the Ingredients section below.

To make sure Taltz injection is safe for you, tell your doctor if you have:

Your doctor may perform tests to make sure you do not have tuberculosis or other infections.

Make sure you are up to date with all age-appropriate vaccinations before you start treatment with this medicine.


Tell your doctor if you are pregnant or plan to become pregnant . It is not known if Taltz can harm your unborn baby. If you are pregnant or you become pregnant, your name may be listed on a pregnancy registry to track the effects of ixekizumab on the baby. The purpose of this registry is to collect information about the health of you and your baby. 


Tell your doctor if you are breastfeeding or planning to breastfeed. It is not known whether this medicine passes into breast milk or if it could harm a nursing baby.

How is Taltz given?

Take this medicine exactly as prescribed. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or longer than recommended.

Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

Taltz is a solution (liquid) injected under the skin (subcutaneously) using a prefilled syringe or a prefilled autoinjector. You may be shown how to use injections at home. Do not give yourself this medicine if you do not understand how to use the injection.

Taltz instructions

For more detailed instructions, including diagrams for all device types, click on this link: Taltz Instructions For Use.

Taltz Dosing information

Usual Adult Taltz Dose for Plaque Psoriasis

Usual Pediatric Taltz Dose for Plaque Psoriasis

Usual Adult Taltz Dose for Psoriatic Arthritis

Usual Adult Taltz Dose for Ankylosing Spondylitis

Usual Adult Taltz Dose for Non-radiographic Axial Spondyloarthritis

Taltz injection is available as: 

Autoinjector: 80 mg/mL solution in a single-dose prefilled autoinjector.

Prefilled Syringe: 80 mg/mL solution in a single-dose prefilled syringe.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Taltz?

Do not share this medicine with another person, even if they have the same symptoms you have.

Do not receive a "live" vaccine while using this injection. The vaccine may not work as well during this time, and may not fully protect you from disease. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

What other drugs will affect Taltz?

Other drugs may interact with this medicine including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

It is important to tell your doctor if you take any of these medicines:

Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with Taltz so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. To check for interactions with Taltz click on the link below.


Active ingredient: ixekizumab

Inactive ingredients: Polysorbate 80, Sucrose, and Water for Injection. Sodium Hydroxide may have been added to adjust pH.

Not made with natural rubber latex.



Taltz (ixekizumab) injection is a registered trademark of Eli Lilly and Company.

Eli Lilly and Company Indianapolis, IN 46285, USA, US License Number 1891.

Popular FAQ

Monoclonal antibodies (mAbs) are man-made proteins that mimic the natural antibodies produced by our immune systems. Monoclonal antibodies can be formulated into medicines to treat various types of illnesses, such as cancer, rheumatoid arthritis or psoriasis. Continue reading

Taltz and Cosentyx are similar in the way they work, their side effects, and their potential for interactions, but Taltz does appear to provide patients with psoriatic arthritis (PA) with more quality-adjusted life-years (QALYs) compared with Cosentyx at a marginally lower cost. Cosentyx may have a quicker onset of effect. Continue reading

Common side effects of Taltz include injection site reactions, conjunctivitis, and nausea. More serious side effects include infections, inflammatory bowel disease, and severe allergic reactions. Continue reading

Treatment with Taltz (ixekizumab) starts to improve symptoms in patients with moderate-to-severe psoriasis within about 1-2 weeks, according to clinical trial results. After 12 weeks, nearly 90% of patients will have significantly clearer skin. Continue reading

Alcohol is not known to interact with Taltz (ixekizumab), a humanized interleukin-17A antagonist used to treat adults and children with moderate-to-severe plaque psoriasis and other conditions.

While Taltz may not interact with alcohol, the American Academy of Dermatology (AAD) and the National Psoriasis Foundation (NPF) recommend that dermatologists strongly advise patients with psoriasis to limit alcohol intake. It is thought that consumption of alcohol increases the risk for severe disease in patients with psoriasis. Continue reading

Weight gain is not a known side effect of Taltz (ixekizumab), a humanized interleukin-17A antagonist used to treat adults and children with moderate-to-severe plaque psoriasis, as well as other conditions.

While body weight can impact how well some drug treatments work, researchers have found that treatment with Taltz is safe and effective regardless of a patient's body weight. Continue reading

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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Taltz only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.