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Taltz Side Effects

Generic Name: ixekizumab

Note: This page contains side effects data for the generic drug ixekizumab. It is possible that some of the dosage forms included below may not apply to the brand name Taltz.

For the Consumer

Applies to ixekizumab: subcutaneous solution

As well as its needed effects, ixekizumab (the active ingredient contained in Taltz) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking ixekizumab, check with your doctor immediately:

More common:
  • Body aches or pain
  • burning, dry, or itching eyes
  • cough or hoarseness
  • difficulty with breathing
  • discharge or excessive tearing
  • ear congestion
  • fever or chills
  • headache
  • itching in the genital or other skin areas
  • loss of voice
  • lower back or side pain
  • nasal congestion
  • painful or difficult urination
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • runny nose
  • sneezing
  • sore mouth or tongue
  • sore throat
  • unusual tiredness or weakness
  • white patches in the mouth or on the tongue
  • Hives or welts, Itching, or skin rash
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • rectal bleeding
  • redness of the skin
  • severe diarrhea
  • severe stomach pain

Minor Side Effects

Some ixekizumab side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
Less common:
  • Nausea

For Healthcare Professionals

Applies to ixekizumab: subcutaneous solution


Common (1% to 10%): Urticaria
Uncommon (0.1% to 1%): Angioedema[Ref]


Common (1% to 10%): Nausea
Uncommon (0.1% to 1%): Oral candidiasis, inflammatory bowel disease[Ref]


Very common (10% or more): Neutropenia (11%)
Common (1% to 10%): Thrombocytopenia[Ref]


Very common (10% or more): Infections (26%), immunogenicity (22%)
Common (1% to 10%): Tinea infections, influenza
Uncommon (0.1% to 1%): Serious infections[Ref]


Very common (10% or more): Injection site reactions (17%), erythema, pain[Ref]


Common (1% to 10%): Conjunctivitis[Ref]


Very common (10% or more): Upper respiratory tract infections (including nasopharyngitis and rhinovirus infection) (14%)
Uncommon (0.1% to 1%): Rhinitis[Ref]


Frequency not reported: Serious hypersensitivity reactions (e.g., anaphylaxis, angioedema, urticaria)[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Taltz Autoinjector (ixekizumab)." Eli Lilly and Company, Indianapolis, IN.

3. Cerner Multum, Inc. "Australian Product Information." O 0

It is possible that some side effects of Taltz may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

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