What are the new drugs for the treatment of plaque psoriasis?
Medically reviewed by Judith Stewart, BPharm Last updated on Apr 22, 2020.
Official Answerby Drugs.com
Interleukin-23 antagonists work by blocking interleukin-23 (IL-23), a pro-inflammatory cytokine thought to play a major role in chronic immune-mediated diseases, including plaque psoriasis.
Interleukin-23 antagonists are part of a wider group of drugs called biologics. Biologics are administered via subcutaneous injection or intravenous infusion and are reserved for moderate to severe cases of psoriasis. Other biologic drugs include tumor necrosis factor-alpha (TNF-alpha) blockers, interleukin 12 and 23 (IL-12/23) antagonists, and interleukin 17 (IL-17) antagonists.
Systemic therapies, including biologic treatments, are only used for psoriasis that has not responded to other treatments (topical treatments and phototherapy).
For more information on other psoriasis drugs, including topical treatments, see Medications for Psoriasis
New Treatments for Plaque Psoriasis - Latest FDA Approvals
|Drug||Administration||Drug Class||Patient Population||Company||FDA Approved for Psoriasis||Psoriasis Indication||Other Indications|
|Skyrizi (risankizumab-rzaa)||subcutaneous injection at weeks 0, 4, then every 12 weeks||interleukin-23 antagonist||adults||AbbVie Inc.||23-Apr-2019||
|Cimzia (certolizumab pegol)||subcutaneous injection every 2 weeks||tumor necrosis factor (TNF) blocker||adults||UCB, Inc.||24-May-2018||
|Ilumya (tildrakizumab-asmn)||subcutaneous injection at weeks 0, 4, then every 12 weeks||interleukin-23 antagonist||adults||Sun Pharmaceutical Industries, Inc.||20-Mar-2018||
|Tremfya (guselkumab)||subcutaneous injection at weeks 0, 4, then every 8 weeks||interleukin-23 antagonist||adults||Janssen Biotech, Inc.||13-Jul-2017||
|Siliq (brodalumab)||subcutaneous injection at weeks 0, 1, and 2, then every 2 weeks||interleukin-17A antagonist||adults||Bausch Health Companies Inc.||15-Feb-2017||
|Taltz (ixekizumab)||subcutaneous injection at weeks 0, 2, 4, 6, 8, 10, and 12, then every 4 weeks||interleukin-17A antagonist||adults and children 6 years and older||Eli Lilly and Company||22-Mar-2016||
|Cosentyx (secukinumab)||subcutaneous injection at weeks 0, 1, 2, 3, and 4, then every 4 weeks||interleukin-17A antagonist||adults||Novartis Pharmaceuticals Corporation||21-Jan-2015||
|Otezla (apremilast)||oral tablets twice daily||phosphodiesterase 4 (PDE4) inhibitor||adults||Celgene Corporation||23-Sep-2014||
subcutaneous injection at weeks 0 and 4, then every
|interleukin-12 and -23 antagonist||adults and children 12 years and older||Janssen Biotech, Inc.||25-Sep-2009||
|Humira (adalimumab)||subcutaneous injection at weeks 0 and 1, then every 2 weeks||tumor necrosis factor (TNF) blocker||adults||AbbVie Inc.||18-Jan-2008||
|Remicade (infliximab)||intravenous infusion at weeks 0, 2 and 6, then every 8 weeks||tumor necrosis factor (TNF) blocker||adults||Janssen Biotech, Inc.||26-Sep-2006||
Adults: subcutaneous injection twice weekly for 3 months then once weekly
Children: subcutaneous injection once weekly
|tumor necrosis factor (TNF) blocker||adults and children 4 years and older||Amgen Inc.||30-Apr-2004||
Humira (adalimumab) Biosimilars
- Amjevita (adalimumab-atto)
- Cyltezo (adalimumab-adbm)
- Hyrimoz (adalimumab-adaz)
- Hadlima (adalimumab-bwwd)
- Abrilada (adalimumab-afzb)
Remicade (infliximab) Biosimilars
- Inflectra (infliximab-dyyb)
- Renflexis (infliximab-abda)
- Ixifi (infliximab-qbtx)
- Avsola (infliximab-axxq)
Enbrel (etanercept) Biosimilars
For more information, see Psoriasis: Treatment Options to Manage Your Symptoms & Skin
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