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How long does clobetasol stay in your system?

Medically reviewed by Carmen Pope, BPharm. Last updated on Aug 21, 2023.

Official answer


It is unknown how long clobetasol stays in your system because the half-life of the drug is not available through any reference source. Some researchers have found that suppression of cortisol levels is still apparent 96 hours after topical use of this medicine, which implies that clobetasol can stay in your system for long periods of time, possibly for up to a few weeks. Clobetasol is not recommended to be used for more than two consecutive weeks.

  • Clobetasol Updated Jan 19, 2021. ASHP.
  • Nakamura RC, Abreu Ld, Duque-Estrada B, Tamler C, Leverone AP. Comparison of nail lacquer clobetasol efficacy at 0.05%, 1% and 8% in nail psoriasis treatment: prospective, controlled and randomized pilot study. An Bras Dermatol. 2012 Mar-Apr;87(2):203-11. doi: 10.1590/s0365-05962012000200003. PMID: 22570023.

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