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What's the dosing schedule for Skyrizi?

Medically reviewed by Leigh Ann Anderson, PharmD. Last updated on June 21, 2022.

Official answer

by Drugs.com

For treatment of plaque psoriasis and psoriatic arthritis in adults, you’ll receive your first two starter doses of Skyrizi four weeks apart, then you’ll have an injection every 12 weeks thereafter.

  • If you are being treated for psoriatic arthritis, your doctor may prescribe Skyrizi to be used alone or in combination with non-biologic disease-modifying antirheumatic drugs (DMARDs), such as methotrexate.
  • Once you start your Skyrizi maintenance injections, you’ll have only 4 doses per year.

For treatment of Crohn's disease in adults, the dosing schedule is three intravenous (given into a vein) starter doses given 4 weeks apart (at Week 0, 4 and 8), then a subcutaneous (under the skin) injection given at Week 12, followed by an injection every 8 weeks thereafter.

  • After completing the initial starter doses, you will receive Skyrizi as an injection under the skin (subcutaneous) using the prefilled cartridge with an on-body injector. You can administer this at home after training from your healthcare provider. The injection dose is delivered in 5 minutes and you will not see the needle.
  • You will receive only 6 doses per year after you receive your starter doses for Crohn's disease management.

Before use, you should receive training on how to inject the medicine. Be sure to read the instructions for use before you start using Skyrizi and each time you get a refill. There may be new information you need to know. If you do not have the instructions, ask your pharmacist for a copy. Use this medicine exactly as directed by your doctor.

Can I use Skyrizi at home?

You can inject subcutaneous (under the skin) Skyrizi with a prefilled syringe or a pen injector for treatment of plaque psoriasis and psoriatic arthritis. You will receive the subcutaneous injections either in your doctor’s office or at home after training by your healthcare provider.

For Crohn's disease, the initial starter intravenous doses are given in a healthcare facility. Then you will receive Skyrizi as an injection under the skin (subcutaneous) using the prefilled cartridge with an on-body injector. You can administer this dose at home after training from your healthcare provider.

What is the typical dose of Skyrizi?

The recommended starter and maintenance dose of Skyrizi (risankizumab) for both plaque psoriasis and psoriatic arthritis is 150 mg given as a subcutaneous (under the skin) injection. ‚Äč

The recommended starter doses of Skyrizi for treatment of Crohn's disease is 600 mg administered by intravenous infusion over at least one hour for the first three doses (Week 0, 4, and 8). Then, the recommended maintenance dosage is 360 mg given by subcutaneous (under the skin) injection at Week 12, and then every 8 weeks, thereafter.

If a dose is missed, administer the dose as soon as possible, then resume dosing at the regularly scheduled time. If you inject too much Skyrizi, call your doctor right away for instructions.

Only use the dose of Skyrizi that your doctor prescribes.

What diseases are Skyrizi used for?

Skyrizi is used to treat adults with moderate or severe plaque psoriasis, psoriatic arthritis, and Crohn's disease.

  • Plaque psoriasis is a chronic (long-term) autoimmune disease in which the cells of your skin are replaced at an unusually fast rate. This causes raised silvery plaques that can be flaky, red, and itchy. In autoimmune diseases the body's immune system starts to mistakenly attack healthy cells and tissues.
  • Psoriatic arthritis is an inflammatory disease of the skin and joints and impacts approximately 30% of patients with psoriasis.
  • Crohn's disease is an inflammatory bowel disease (IBD) that is characterized by ongoing inflammation (pain and swelling) of the gastrointestinal tract. Crohn's-related inflammation usually affects the intestines but it may occur anywhere from the mouth to the anus.

This is not all the information you need to know about Skyrizi (risankizumab-rzaa) for safe and effective use and does not take the place of talking to your doctor about your treatment. Review the full Skyrizi information here and discuss this information and any questions you have with your doctor or other health care provider.

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