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How long does it take for Skyrizi to work?

Medically reviewed by Melisa Puckey, BPharm. Last updated on May 13, 2020.

Official Answer

by Drugs.com

Skyrizi (risankizumab-rzaa) is an injection given under the skin (subcutaneous injection) to treat patients who have moderate or severe plaque psoriasis (raised, silvery flaking of the skin).

How long does it take for Skyrizi to work?

First of all, how do you measure improvement in psoriasis?

  • To measure how good or bad your psoriasis is, a score is used called the PASI (Psoriasis Area and Severity Index).
  • It scores your psoriasis on redness, thickness, amount of scaling and how much of the body is affected.
  • If your psoriasis score has a 90% reduction it is called PASI 90. If you had a 100% reduction in your PASI score would be a PASI 100.

Two clinical trials (UltlMMa-1 and UltlMMa-2) looked at how long it takes Skyrizi to work on plaque psoriasis.

The percentage of patients who achieved 90% improvement in their PASI score (PASI 90)

  • 44% at week 4
  • 75% at week 16
  • 82% at week 52

The percentage of patients who achieved 100% improvement in their PASI score (PASI 100)

  • 42% at week 16
  • 57% at week 52
PASI 90 PASI 100
Week 4 44% Not available
Week 16 75% 42%
Week 52 82% 57%

Bottom Line:

  • Skyrizi injection starts to work within a few weeks, with 44% of patients seeing a 90% reduction in their PASI score in 4 weeks.
  • Skyrizi continues to improve plaque psoriasis symptoms so that by week 52, 82% have a PASI 90 and by 57% achieve a PASI 100.
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