Does Feverfew interact with any drugs?

Medically reviewed by Leigh Ann Anderson, PharmD. Last updated on May 15, 2025.

Official Answer by Drugs.com

Feverfew, an herbal supplement that is a member of the daisy family, may interact with over 40 medicines. This includes drugs used to help prevent blood clots like the anticoagulant warfarin.

Most drug interactions that may occur with feverfew are reported as mild; however, most interactions are not well documented.

Feverfew may be used as an herbal supplement to prevent migraine headaches and associated nausea and vomiting; however, the evidence is not conclusive on its effectiveness for this condition.

Lab studies suggest feverfew may increase the risk of bleeding, especially in people with blood-clotting disorders or using blood thinners to help prevent clots. Examples of drugs that may interfere include:

aspirin
warfarin (Jantoven)
heparin
Eliquis (apixaban)
Plavix (clopidogrel)
Pradaxa (dabigatran)
Savaysa (edoxaban)
Xarelto (rivaroxaban)
low molecular weight heparins like enoxaparin or dalteparin

If you take any medicine used to anticoagulate (thin) your blood to help prevent clot, speak with your doctor before using feverfew.

Nonsteroidal anti-inflammatory agents (NSAIDs) like ibuprofen or naproxen may also theoretically increase bleeding if used with feverfew. NSAIDs are most commonly used to treat mild pain, headache and inflammation.

Call your doctor at once if you have signs of bleeding such as: swelling, pain, dizziness, weakness, bleeding gums, nosebleeds, heavy menstrual periods or abnormal vaginal bleeding, blood in your urine, bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds, or any bleeding that will not stop.

This is not a complete list of all the drugs that may interact with feverfew. For more information, review:

Drug interactions with Feverfew (in more detail)

This is not all the information you need to know about Feverfew for safe and effective use and does not take the place of your doctor’s directions. Review the full product information and discuss this information and any questions you have with your doctor or other health care provider.

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