Generic Name: clopidogrel (kloe PID oh grel)
Brand Names: Plavix
What is Plavix?
Plavix may also be used for purposes not listed in this medication guide.
Plavix keeps your blood from coagulating (clotting) to prevent unwanted blood clots that can occur with certain heart or blood vessel conditions. Because of this drug action, Plavix can make it easier for you to bleed, even from a minor injury.
Your doctor will perform blood tests to make sure you do not have certain genetic conditions that would prevent you from safely using Plavix.
You should not use Plavix if you have any active bleeding such as a stomach ulcer or bleeding in the brain (such as from a head injury).
Plavix increases your risk of bleeding, which can be severe or life-threatening. Call your doctor or seek emergency medical attention if you have bleeding that will not stop, if you have blood in your urine, black or bloody stools, or if you cough up blood or vomit that looks like coffee grounds.
If you need surgery or dental work, tell the surgeon or dentist ahead of time that you take Plavix.
Before taking this medicine
You should not use Plavix if you are allergic to clopidogrel, or if you have any active bleeding such as a stomach ulcer or bleeding in the brain (such as from a head injury).
Some medicines can interact with clopidogrel and should not be used at the same time. Your doctor may need to change your treatment plan if you also take other medicines, especially certain stomach acid reducers (esomeprazole, omeprazole, Nexium, Prilosec).
To make sure Plavix is safe for you, tell your doctor if you have:
a bleeding or blood clotting disorder, such as TTP (thrombocytopenic purpura) or hemophilia;
a history of stroke, including TIA ("mini-stroke");
a stomach ulcer or ulcerative colitis;
kidney disease; or
if you are allergic to medicines like clopidogrel, such as prasugrel, ticagrelor, or ticlopidine.
Plavix is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
It is not known whether clopidogrel passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.
How should I take Plavix?
Take Plavix exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Plavix can be taken with or without food.
Because Plavix keeps your blood from clotting, it can also make it easier for you to bleed, even from a minor injury. Contact your doctor or seek emergency medical attention if you have bleeding that will not stop.
If you need surgery or dental work, tell the surgeon or dentist ahead of time that you are using this medicine. You may need to stop using the medicine for a short time before having surgery, to prevent excessive bleeding. Follow your doctor's instructions and start taking this medicine again as soon as possible.
You should not stop using this medicine suddenly. Use Plavix regularly even if you feel fine or have no symptoms. Get your prescription refilled before you run out of medicine completely.
Store at room temperature away from moisture and heat.
See also: Dosage Information (in more detail)
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking Plavix?
Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.
Avoid drinking alcohol. It may increase your risk of bleeding in your stomach or intestines.
Plavix side effects
Get emergency medical help if you have any signs of an allergic reaction to Plavix: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Plavix may cause you to bleed more easily, which can be severe or life-threatening. Seek emergency medical attention if you have any unusual bleeding, or bleeding that will not stop. You may also have bleeding on the inside of your body, such as in your stomach or intestines. Call your doctor at once if you have blood in your urine, black or bloody stools, or if you cough up blood or vomit that looks like coffee grounds.
Call your doctor at once if you have any other serious side effects:
easy bruising, purple or red pinpoint spots under your skin;
pale skin, weakness, fever, or jaundice (yellowing of the skin or eyes);
little or no urination;
fast heart rate, feeling short of breath;
nausea, vomiting, diarrhea, stomach pain;
heart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating; or
signs of a stroke - sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Plavix?
Certain other medicines may increase your risk of bleeding. Tell your doctor if you take aspirin, especially if you have had a stroke. Talk to your doctor about whether you should take aspirin with Plavix.
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Plavix, especially:
a blood thinner - (warfarin, Coumadin, Jantoven);
NSAIDs (nonsteroidal anti-inflammatory drugs) - aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others; or
an antidepressant - citalopram, desvenlafaxine, duloxetine, escitalopram, fluoxetine (Prozac), fluvoxamine, milnacipran, paroxetine, sertraline (Zoloft), trazodone, venlafaxine, vilazodone, and others.
This list is not complete. Other drugs may interact with clopidogrel, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
More about Plavix (clopidogrel)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Images
- Drug Interactions
- Compare Alternatives
- Support Group
- Pricing & Coupons
- En Español
- 45 Reviews – Add your own review/rating
- Generic Availability
- Drug class: platelet aggregation inhibitors
Related treatment guides
Where can I get more information?
- Your pharmacist can provide more information about Plavix.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Plavix only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2018 Cerner Multum, Inc. Version: 13.01. Revision Date: 2017-8-15, 10:03:22 AM.