Medically reviewed: November 28, 2017
What is Activase?
Activase is a thrombolytic (THROM-bo-LIT-ik) drug, sometimes called a "clot-busting" drug. It helps your body produce a substance that dissolves unwanted blood clots.
Activase is used to treat a stroke caused by a blood clot or other obstruction in a blood vessel. This medicine is also used to prevent death from a heart attack (acute myocardial infarction).
Activase is also used to treat a blood clot in the lung (pulmonary embolism).
Activase is also used to dissolve blood clots that have formed in or around a catheter placed inside a blood vessel. This improve the flow of medicines injected in through the catheter, or blood drawn out through the catheter.
Activase may also be used for purposes not listed in this medication guide.
Activase increases your risk of severe or fatal bleeding, especially from a surgical incision, or from the skin where a needle was inserted. Seek emergency help if you have any bleeding that will not stop.
Before taking this medicine
You should not be treated with Activase if you are allergic to it, or if you have:
active bleeding inside your body;
a brain tumor or aneurysm (dilated blood vessel);
severe or uncontrolled high blood pressure;
a bleeding or blood clotting disorder such as hemophilia;
bleeding inside your brain (if you are receiving Activase to treat a stroke); or
a recent history of stroke (if you are receiving Activase for pulmonary embolism).
If possible before you receive Activase, tell your doctor if you have ever had:
any type of stroke;
bleeding in your brain, stomach, intestines, or urinary tract;
high blood pressure;
an infection of the lining of your heart (also called bacterial endocarditis);
a serious injury or major surgery;
severe bruising or infection around a vein where an IV was placed;
an organ biopsy;
eye problems caused by diabetes;
liver or kidney disease; or
if you are pregnant or breastfeeding.
In an emergency situation it may not be possible to tell your caregivers if you are pregnant or breast-feeding. Make sure any doctor caring for your pregnancy or your baby knows you have received this medicine.
How is alteplase given?
Activase is injected into a vein through an IV. A healthcare provider will give you this injection.
Activase is usually given within 3 hours after the first signs of stroke or heart attack symptoms. Your breathing, blood pressure, oxygen levels, and other vital signs will be watched closely.
You will also be watched closely for several hours after receiving Activase, to make sure you do not have an allergic reaction to the medication.
When used to clear blood clots from a catheter, Activase is given in 1 or 2 doses. After the first dose, a small amount of blood is withdrawn through the catheter to make sure it is cleared of blood clots. If blood cannot be easily withdrawn 2 hours after the first dose of this medicine, a second dose may be given.
After treatment with Activase, your doctor may prescribe a blood thinner or other medication to help prevent future blood clots. Carefully follow all dosing instructions. These medications can make it easier for you to bleed, even from a minor injury.
What happens if I miss a dose?
Because you will receive Activase in a clinical setting, you are not likely to miss a dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid after receiving Activase?
Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.
Activase side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Activase increases your risk of bleeding, which can be severe or fatal. Call your doctor or seek emergency medical attention if you have bleeding that will not stop. Bleeding may occur from a surgical incision, or from the skin where a needle was inserted during a blood test or while receiving injectable medication. You may also have bleeding on the inside of your body, such as in your stomach or intestines, kidneys or bladder, brain, or within the muscles.
Call your doctor or get emergency medical help if you have signs of bleeding, such as:
sudden headache, feeling very weak or dizzy;
bleeding gums, nosebleeds;
bleeding from a wound, incision, catheter, or needle injection;
bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
red or pink urine;
heavy menstrual periods or abnormal vaginal bleeding; or
sudden numbness or weakness (especially on one side of the body), slurred speech, problems with vision or balance.
Also call your doctor at once if you have:
chest pain or heavy feeling, pain spreading to the jaw or shoulder, nausea, sweating, general ill feeling;
swelling, rapid weight gain, little or no urination;
severe stomach pain, nausea, and vomiting;
darkening or purple discoloration of your fingers or toes;
very slow heartbeats, shortness of breath, feeling light-headed;
sudden severe back pain, muscle weakness, numbness or loss of feeling in your arms or legs;
increased blood pressure--severe headache, blurred vision, pounding in your neck or ears, anxiety, nosebleed; or
Bleeding is the most common side effect of Activase.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Activase?
Tell your doctor about all your current medicines and any you start or stop using, especially:
any medication used to treat or prevent blood clots;
This list is not complete. Other drugs may interact with alteplase, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2018 Cerner Multum, Inc. Version: 2.01.
More about Activase (alteplase)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Español
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- Drug class: thrombolytics