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Activase

Generic name: alteplaseAL-te-plase ]
Brand names: Activase, Cathflo Activase
Drug class: Thrombolytics

Medically reviewed by Drugs.com on Jun 3, 2024. Written by Cerner Multum.

What is Activase?

Activase is a thrombolytic (THROM-bo-LIT-ik) drug, sometimes called a "clot-busting" drug. It helps your body produce a substance that dissolves unwanted blood clots.

Activase is used to treat a stroke caused by a blood clot or other obstruction in a blood vessel. This medicine is also used to prevent death from a heart attack (acute myocardial infarction).

Activase is also used to treat a blood clot in the lung (pulmonary embolism).

Activase is also used to dissolve blood clots that have formed in or around a catheter placed inside a blood vessel. This improve the flow of medicines injected in through the catheter, or blood drawn out through the catheter.

Activase may also be used for purposes not listed in this medication guide.

Activase side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Activase increases your risk of bleeding, which can be severe or fatal. Call your doctor or seek emergency medical attention if you have bleeding that will not stop. Bleeding may occur from a surgical incision, or from the skin where a needle was inserted during a blood test or while receiving injectable medication. You may also have bleeding on the inside of your body, such as in your stomach or intestines, kidneys or bladder, brain, or within the muscles.

Call your doctor or get emergency medical help if you have signs of bleeding, such as:

Also call your doctor at once if you have:

Bleeding is the most common side effect of alteplase.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings

Activase increases your risk of severe or fatal bleeding, especially from a surgical incision, or from the skin where a needle was inserted. Seek emergency help if you have any bleeding that will not stop.

Before taking this medicine

You should not be treated with Activase if you are allergic to it, or if you have:

If possible before you receive Activase, tell your doctor if you have ever had:

In an emergency situation it may not be possible to tell your caregivers if you are pregnant or breast-feeding. Make sure any doctor caring for your pregnancy or your baby knows you have received Activase.

How is Activase given?

Activase is given as an infusion into a vein. A healthcare provider will give you this injection.

Activase is usually given within 3 hours after the first signs of stroke or heart attack symptoms. Your breathing, blood pressure, oxygen levels, and other vital signs will be watched closely.

You will also be watched closely for several hours after receiving Activase, to make sure you do not have an allergic reaction to the medication.

When used to clear blood clots from a catheter, Activase is given in 1 or 2 doses.

Your doctor may prescribe a blood thinner or other medication to help prevent future blood clots. Carefully follow all dosing instructions. These medications can make it easier for you to bleed, even from a minor injury.

lisinopril, aspirin, metoprolol, clopidogrel, Eliquis, warfarin, apixaban, Xarelto, Plavix, rivaroxaban

What happens if I miss a dose?

Because you will receive Activase in a clinical setting, you are not likely to miss a dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid after receiving Activase?

Ask your doctor before taking aspirin or ibuprofen (Motrin, Advil) shortly after you have received Activase. These medications can increase your risk of bleeding.

Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.

What other drugs will affect Activase?

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect Activase, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Does Activase interact with my other drugs?

Enter other medications to view a detailed interaction report.

Activase Biosimilars

Biosimilar and interchangeable products are biological products that are highly similar to and have no clinically meaningful differences from the reference product.

Reference products

These are biological products that have already been approved by the FDA, against which biosimilar products are compared. There are 2 for Activase.

Activase (alteplase) - Genentech, Inc.
Formulation type Strength
Single-Dose Vial 100 mg
Single-Dose Vial 50 mg
Cathflo Activase (alteplase) - Genentech, Inc.
Formulation type Strength
Single-Dose Vial 2 mg

View Cathflo Activase information in detail.

Popular FAQ

What is the antidote for Activase?

There is no antidote for Activase; if a patient experiences severe bleeding during Activase therapy, immediately discontinue treatment and provide supportive therapy such as tranexamic acid or aminocaproic acid, or fresh frozen plasma or cryoprecipitate if fibrinogen levels are less than 150mg/dL. Stop all other antiplatelet or anticoagulant treatments and investigate (eg, CT brain, CT abdo/pelvis; FBC, coagulation profile [repeat every 2 hours until bleeding controlled]). Continue reading

Is Activase the same as tPA?

Yes, Activase is the same as tPA but technically tPA is an abbreviation for tissue plasminogen activator which is the drug class that encompasses all tissue plasminogen activators, of which there are 3 that have been FDA approved in the United States, namely Activase (generic name alteplase), Retavase (generic name reteplase), TNKase (generic name Tenecteplase). Sometimes healthcare professionals use "tPA" to refer to Activase because it was the first tissue plasminogen activator that was approved. But errors may arise because staff get confused between the abbreviation TNK and tPA, which has resulted in TNKase being given to a stroke patient instead of the intended Activase (TNKase is not approved for stroke patients).

Continue reading
How is Activase (alteplase) given/administered?

How Activase is given or administered depends upon the patient’s weight and what it is being used to treat (such as a stroke, pulmonary embolism, or myocardial infarction. For example, when used to treat a heart attack (myocardial infarction), there are two Activase dose regimens, an accelerated and a 3-hour regimen, with different recommendations depending on if the patient is over 67kg or not. For the accelerated regimen, adults weighing 67 kg or less get a 15 mg IV bolus, followed by 0.75 mg/kg IV (not to exceed 50 mg) infused over 30 minutes, and then 0.5 mg/kg IV (not to exceed 35 mg) over the next 60 minutes Adults greater than or equal to 67 kg get a 15 mg IV bolus, followed by 50 mg IV infused over 30 minutes, and then 35 mg IV infused over the next 60 minutes Continue reading

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.