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Dupixent

Generic Name: dupilumab (doo PIL us mab)
Brand Name: Dupixent

Medically reviewed by Judith Stewart, BPharm. Last updated on Nov 12, 2020.

What is Dupixent?

Dupixent (dupilumab) is used to treat moderate-to-severe eczema (atopic dermatitis) that cannot be controlled with topical medicines applied to the skin. Dupixent is used for eczema in adults and children at least 6 years old.

Dupixent is also used together with other medications to treat moderate-to-severe asthma that is not controlled with other asthma medicines. It is used for asthma in adults and children at least 12 years old.

Dupixent is used only in adults to treat a condition called chronic rhinosinusitis (long-term sinus inflammation) that is associated with nasal polyps.

Important Information

Follow all directions on your Dupixent label and package insert. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

To make sure Dupixent is safe for you, tell your doctor if you have:

  • an allergy to dupilumab
  • if you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.

Dupilumab may interact with other drugs or health problems.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Dupixent with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

Before taking this medicine

You should not use Dupixent if you are allergic to dupilumab.

Dupixent should not be given to a child younger than 12 years old to treat asthma, or younger than 6 years old to treat eczema.

To make sure Dupixent is safe for you, tell your doctor if you have:

  • eye problems;

  • a parasite infection (such as roundworms or tapeworms); or

  • if you are scheduled to receive any vaccine.

If you use Dupixent to treat eczema or chronic rhinosinusitis with nasal polyposis, tell your doctor if you also have asthma.

Tell your doctor if you are pregnant or breastfeeding.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of dupilumab on the baby.

How should I use Dupixent?

Use Dupixent exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.

Dupixent is not a rescue medicine for asthma attacks. Use only fast-acting inhalation medicine for an attack. Seek medical attention if your breathing problems get worse quickly, or if you think your asthma medications are not working as well.

Dupixent is injected under the skin, usually once every 2 to 4 weeks. Your first dose may be given in 2 injections.

A healthcare provider may teach you how to properly use the medication by yourself. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don't understand all instructions.

Do not shake the prefilled syringe or injection pen. Prepare your injection only when you are ready to give it. Do not use if the medicine looks cloudy, has changed colors, or has particles in it. Call your pharmacist for new medicine.

Store this medicine in the original carton in the refrigerator. Protect from light and do not freeze.

Take a syringe or pen out of the refrigerator and let it reach room temperature for 30 to 45 minutes before injecting your dose. Leave the needle cap on until you are ready to inject your dose.

You may store a prefilled syringe or injection pen at cool room temperature for up to 14 days. Throw the medicine away if not used within 14 days. Do not put it back into the refrigerator.

Each prefilled syringe or injection pen is for one use only. Throw it away after one use, even if there is still medicine left inside.

Use a needle and syringe or pen only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

If you also use other medications to treat eczema or asthma, do not change your doses or stop using the other medications without your doctor's advice.

Dupixent dosing information

Usual Adult Dose for Atopic Dermatitis:

Initial dose: 600 mg subcutaneously (two 300 mg injections in different sites)
Maintenance dose: 300 mg subcutaneously every other week

Comments:
-This drug can be used with or without topical corticosteroids.
-Topical calcineurin inhibitors may be used but should be reserved for problem areas only (i.e., face, neck, intertriginous and genital areas).
-If a dose is missed, administer within 7 days then resume the original schedule; if administered within 7 days, it should be skipped until the next dose.

Use: For moderate-to-severe atopic dermatitis not adequately controlled with topical prescription therapies or when those therapies are not advisable

Usual Adult Dose for Asthma:

400 mg subcutaneously (two 200 mg injections) initially, followed by 300 mg subcutaneously every other week
OR
600 mg subcutaneously (two 300 mg injections) initially, followed by 300 mg subcutaneously every other week

For patients requiring concomitant oral corticosteroids or with comorbid moderate-to-severe atopic dermatitis, start with an initial dose of 600 mg subcutaneously followed by 300 mg subcutaneously every other week.

Use: As add-on maintenance treatment in patients with moderate-to-severe asthma with an eosinophilic phenotype or with oral corticosteroid dependent asthma

Usual Pediatric Dose for Atopic Dermatitis:

12 years and older:
Less than 60 kg:
-Initial dose: 400 mg subcutaneously (two 200 mg injections in different sites)
-Maintenance dose: 200 mg subcutaneously every other week
60 kg or greater:
-Initial dose: 600 mg subcutaneously (two 300 mg injections in different sites)
-Maintenance dose: 300 mg subcutaneously every other week

Comments:
-This drug can be used with or without topical corticosteroids.
-Topical calcineurin inhibitors may be used but should be reserved for problem areas only (i.e., face, neck, intertriginous and genital areas).
-If a dose is missed, administer within 7 days then resume the original schedule; if administered within 7 days, it should be skipped until the next dose.

Use: For patients 12 years and older with moderate-to-severe atopic dermatitis not adequately controlled with topical prescription therapies or when those therapies are not advisable

Usual Pediatric Dose for Asthma:

12 years and older:
400 mg subcutaneously (two 200 mg injections) initially, followed by 300 mg subcutaneously every other week
OR
600 mg subcutaneously (two 300 mg injections) initially, followed by 300 mg subcutaneously every other week

For patients requiring concomitant oral corticosteroids or with comorbid moderate-to-severe atopic dermatitis, start with an initial dose of 600 mg subcutaneously followed by 300 mg subcutaneously every other week.

Use: As add-on maintenance treatment in patients with moderate-to-severe asthma with an eosinophilic phenotype or with oral corticosteroid dependent asthma

What happens if I miss a dose?

If you miss your injection by 7 days or less, use the missed dose as soon as you remember and then go back to your regular injection schedule.

If you are more than 7 days late for the injection:

  • For the every-other-week injection schedule: Skip the missed dose and use the medicine at your next scheduled injection time.

  • For the every-4-weeks schedule: Start a new dosing schedule on the day you use the missed injection and use your next injection 4 weeks later.

Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Dupixent?

Do not receive a "live" vaccine while using Dupixent. The vaccine may not work as well during this time, and may not fully protect you from disease. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

Dupixent side effects

Get emergency medical help if you have signs of an allergic reaction to Dupixent: hives, rash, itching; fever, swollen glands, joint pain; feeling light-headed, difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • new or worsening eye pain or discomfort;

  • vision changes;

  • watery eyes (your eyes may be more sensitive to light);

  • feeling like something is in your eye; or

  • blood vessel inflammation--fever, chest pain, trouble breathing, skin rash, numbness or prickly feeling in your arms or legs.

Common Dupixent side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Dupixent?

Tell your doctor about all your other medicines, especially:

  • an oral, inhaled, or topical steroid medicine; or

  • any medicine to treat asthma.

This list is not complete. Other drugs may interact with dupilumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Dupixent only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Popular FAQ

No, Dupixent is not an immunosuppressant or a steroid. Dupixent works by targeting a type of protein called an interleukin, that is involved in inflammation. Dupixent calms an overreactive immune system but it does not suppress the immune system. This leads to fewer and less severe symptoms of chronic inflammatory conditions, such as atopic dermatitis or asthma. Continue reading

Yes, it does appear that Dupixent can cause joint pain although this is not listed in the product information as a side effect. However, several reports of painful joints, tendinitis, and arthritic-like pain associated with Dupixent use have appeared recently in the literature including a 55-year-old woman with multiple joint and thumb pain, a 38-year-old with severe pain and stiffness in one ankle that progressed to her knees, hips and elbows within days of her first dose, and a 40-year-old with generalized joint pain and morning stiffness. Continue reading

Yes, it does appear that Dupixent can cause weight gain, although this is not listed as a side effect in the product information. A case series of 12 people prescribed Dupixent reported an average weight gain of 6.1kg over one year – the amount of weight gained ranged from 0.1kg to 18.0kg. Anecdotally, blog sites also report weight gain as a side effect. How Dupixent causes weight gain is not known; however, people should be informed that weight gain may be a possible side effect of Dupixent. Continue reading

Dupixent is associated with several different eye problems, including conjunctivitis, blepharitis, dry eyes, itchy eyes, and keratitis. The cause of the eye problems is thought to be due to Dupixent blocking interleukin-13 (IL-13), an inflammatory protein that also stimulates the production of goblet cells. Goblet cells are responsible for creating mucus in the eye and ensuring the stability of tears. So when Dupixent blocks IL-13 it also lowers the numbers of epithelial goblet cells leading to eye inflammation and eye problems. Continue reading

Dupixent is not a cure for eczema; however, it does effectively reduce symptoms in the majority of people prescribed it. Dupixent significantly reduces itching, skin appearance, the frequency of AD flares, sleep, and quality of life in most people. However, there does appear to be a subset of people who only partially respond to Dupixent (partial responders), or who respond initially, and then their symptoms return (non-durable responders). Continue reading

Dupixent helps to prevent severe asthma attacks and improve breathing in people with moderate-to-severe eosinophilic or oral steroid-dependent asthma who are aged 12 years and older. It may also reduce the need for oral corticosteroids, such as prednisone, and improve the overall quality of life. Dupixent is used in addition to current asthma medications, such as albuterol and other bronchodilators. Dupixent will not resolve an acute asthma attack. Continue reading

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