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Pronunciation: DU-pix-ent
Generic name: dupilumab
Dosage form: injection for subcutaneous use
Drug class: Interleukin inhibitors

Medically reviewed by Carmen Pope, BPharm. Last updated on Feb 8, 2024.

What is Dupixent?

Dupixent (dupilumab) is a biologic that is given by subcutaneous (under the skin) injection that may be used to treat the following inflammatory conditions:

Dupixent works by targeting and binding to a protein that is associated with inflammation called interleukin-4 (IL-4) receptor alpha subunit (IL-4Ra)], preventing IL-4 and IL-3 signaling. This inhibits the inflammatory response including the release of proinflammatory cytokines, chemokines, nitric oxide, and IgE. Dupixent is an interleukin-4 receptor alpha antagonist.

Dupixent was first FDA-approved on March 28, 2017.


Hypersensitivity reactions including anaphylaxis, serum sickness, angioedema, urticaria, rash, erythema nodosum, and erythema multiforme have been reported with Dupixent. Do not use Dupixent if you are allergic to dupilumab or any of the ingredients. Stop Dupixent immediately and contact your healthcare provider if you develop any allergy symptoms.

May cause conjunctivitis and keratitis. Report new onset or worsening eye symptoms to your healthcare provider. Your healthcare provider may suggest an ophthalmological examination.

May increase the risk of developing eosinophilic conditions. Tell your doctor if you develop a red or purple rash, shortness of breath, or tingling or nerve pain in your hands or feet.

Your healthcare provider will decide if you need to continue with oral, topical, or inhaled corticosteroids while being treated with Dupixent. These should be reduced gradually, do not discontinue without your doctor’s advice.

Report new onset or worsening joint pain or swelling to your healthcare provider. Further investigation may be required.

Any pre-existing worm or parasitic (helminth) infections should be treated before initiating Dupixent. If patients become infected during treatment and do not respond to antihelminths, then discontinue Dupixent until the infection resolves.

Avoid the use of live vaccines. May reduce the immune response to other vaccinations.

It is not known if Dupixent is safe and effective for children with:

Before taking

Before using Dupixent tell your healthcare provider about all your medical conditions, including if you:


It is not known whether Dupixent will harm your unborn baby. There is a pregnancy exposure registry for women who use Dupixent during pregnancy. Your healthcare provider can enroll you in this registry or you can enroll yourself or get more information about the registry by calling 1-877-311-8972 or going to


It is not known whether Dupixent passes into breast milk.

How should I use Dupixent?

Use Dupixent exactly as prescribed by your doctor. Follow all directions on your Dupixent label and package insert.

Dupixent is not a rescue medicine for asthma attacks. Use only fast-acting inhalation medicine for an attack.

A healthcare provider may teach you how to properly use the medication by yourself. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don't understand all the instructions.

This drug can be used with or without topical corticosteroids. Topical calcineurin inhibitors may be used but should be reserved for problem areas only (e.g., face, neck, intertriginous, and genital areas).

What happens if I miss a dose?

If you miss your injection by 7 days or less, use the missed dose as soon as you remember and then start a new every-week dose schedule from the time you remember.

If your dose schedule is every other week and you miss a dose of Dupixent give the injection within 7 days from the missed dose, then continue with your original schedule. If the missed dose is not given within 7 days, wait until the next scheduled dose to give your injection.

If your dose schedule is every 4 weeks and you miss a dose of Dupixent, give the injection within 7 days from the missed dose, then continue with your original schedule. If the missed dose is not given within 7 days, start a new every 4-week dose schedule from the time you remember to take your injection.

Do not use two doses at one time.

What happens if I overdose?

If you inject too much Dupixent, call your healthcare provider or Poison Help line at 1-800-222-1222 or go to the nearest hospital emergency room right away.

What should I avoid while using Dupixent?

Do not receive a "live" vaccine while using Dupixent. The vaccine may not work as well during this time and may not fully protect you from disease. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

What are the side effects of Dupixent?

Get emergency medical help if you have signs of an allergic reaction to Dupixent: hives, rash, itching; fever, swollen glands, joint pain; feeling light-headed, difficulty breathing; swelling of your face, lips, tongue, or throat.

Dupixent may cause serious side effects. Call your doctor at once if you have:

The most common side effects of Dupixent include:

The following additional side effects have been reported with Dupixent:

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all of the possible side effects of Dupixent. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

What other drugs will affect Dupixent?

Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Especially tell your healthcare provider if you:

Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine or other asthma medicine to come back. This list is not complete. Other drugs may interact with dupilumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.


Store refrigerated at 2°C to 8°C (36°F to 46°F) in the original carton to protect from light. You may store a prefilled syringe or injection pen at cool room temperature for up to 14 days. Do not store above 25°C (77°F).

Throw the medicine away if not used within 14 days. Do not put it back into the refrigerator. Do not expose it to heat or direct sunlight. Do NOT freeze. Do NOT shake.


Active: dupilumab.

Inactive: L-arginine hydrochloride, L-histidine, polysorbate 80, sodium acetate, sucrose, and water for injection.

The pre-filled syringe is available as 300mg/2mL, 200mg/1.14mL, and 100mg/0.67mL.

The pre-filled pen is available as 300mg/2mL, and 200mg/1.14 mL.


Sanofi-aventis U.S. LLC and Regeneron Pharmaceuticals Inc.

Popular FAQ

Dupixent can start to work in 2 to 4 weeks to relieve your symptoms of moderate-to-severe eczema, asthma, or chronic rhinosinusitis with nasal polyps. In studies of eosinophilic esophagitis, improved inflammation, swallowing or other symptoms was seen in at 24 weeks In patients 12 years and older and at 16 weeks in 1 to 11 years olds. For adults with prurigo nodularis, improved itching was seen at 12 and 24 weeks, and reduced skin lesions (clear or almost clear skin) at 24 weeks. Continue reading

Injections can be painful for many people, including injections with Dupixent (dupilumab). The amount of discomfort people feel from injections can depend on many factors, including the temperature of the medication that is being injected and individual pain tolerance. However, there are some things you can do to reduce pain and discomfort from your Dupixent injection. Continue reading

Dupixent is associated with several different eye problems, including conjunctivitis, blepharitis, dry eyes, itchy eyes, and keratitis. The cause of the eye problems is thought to be due to Dupixent blocking interleukin-13 (IL-13), an inflammatory protein that also stimulates the production of goblet cells. Goblet cells are responsible for creating mucus in the eye and ensuring the stability of tears. So when Dupixent blocks IL-13 it also lowers the numbers of epithelial goblet cells leading to eye inflammation and eye problems. Continue reading

No, Dupixent (dupilumab) is not an immunosuppressant or a steroid. Dupixent works by targeting a type of protein called an interleukin, that is involved in inflammation. Dupixent calms an overreactive immune system but does not suppress the immune system. This leads to fewer and less severe episodes of inflammation when used to treat conditions such as atopic dermatitis or asthma. Continue reading

Yes, it does appear that Dupixent can cause weight gain, although this is not listed as a side effect in the product information. A case series of 12 people prescribed Dupixent reported an average weight gain of 6.1kg over one year – the amount of weight gained ranged from 0.1kg to 18.0kg. Anecdotally, blog sites also report weight gain as a side effect. How Dupixent causes weight gain is not known; however, people should be informed that weight gain may be a possible side effect of Dupixent. Continue reading

Dupixent can stay out of the fridge for a maximum of 14 days at room temperature (up to 77°F [25°C]). If you do not use it within 14 days, then it must be thrown away. Do not expose Dupixent to temperatures above 77°F and do not put it back in the refrigerator if it has been inadvertently left out and allowed to warm up to room temperature. Continue reading

Dupixent has not been reported to have a drug interaction with alcohol. A few case reports of flushing (facial redness) have been reported by people who used Dupixent and drank alcohol, but it is not known if this was caused by the medicine. If you choose to drink, it is always best to drink in moderation and check with your healthcare provider if you take any medication. Continue reading

Yes, it does appear that Dupixent can cause joint pain although this is not listed in the product information as a side effect. However, several reports of painful joints, tendinitis, and arthritic-like pain associated with Dupixent use have appeared recently in the literature including a 55-year-old woman with multiple joint and thumb pain, a 38-year-old with severe pain and stiffness in one ankle that progressed to her knees, hips and elbows within days of her first dose, and a 40-year-old with generalized joint pain and morning stiffness. Continue reading

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.