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Dupixent Dosage

Generic name: Dupilumab 300mg in 2mL
Dosage form: injection, solution

Medically reviewed by Drugs.com. Last updated on Jun 19, 2020.

DUPIXENT is administered by subcutaneous injection, either by pre-filled syringe or pre-filled pen. The DUPIXENT pre-filled pen is only for use in adults and adolescents aged 12 years and older.

Atopic Dermatitis

Dosing in Adults

The recommended dose of DUPIXENT for adult patients is an initial dose of 600 mg (two 300 mg injections), followed by 300 mg given every other week (Q2W).

Dosing in Pediatric Patients (6 to 17 Years of Age)

The recommended dose of DUPIXENT for patients 6 to 17 years of age is specified in Table 1.

Table 1: Dose of DUPIXENT for Subcutaneous Administration in Pediatric Patients (6 to 17 Years of Age)

Body Weight Initial Dose Subsequent Doses
15 to less than 30 kg 600 mg (two 300 mg injections) 300 mg every 4 weeks (Q4W)
30 to less than 60 kg 400 mg (two 200 mg injections) 200 mg every other week (Q2W)
60 kg or more 600 mg (two 300 mg injections) 300 mg every other week (Q2W)

Concomitant Topical Therapies

DUPIXENT can be used with or without topical corticosteroids. Topical calcineurin inhibitors may be used, but should be reserved for problem areas only, such as the face, neck, intertriginous and genital areas.

Asthma

The recommended dose of DUPIXENT for adults and adolescents (12 years of age and older) is:

  • an initial dose of 400 mg (two 200 mg injections) followed by 200 mg given every other week or
  • an initial dose of 600 mg (two 300 mg injections) followed by 300 mg given every other week
  • for patients with oral corticosteroids-dependent asthma, or with co-morbid moderate-to-severe atopic dermatitis for which DUPIXENT is indicated, start with an initial dose of 600 mg followed by 300 mg given every other week

Chronic Rhinosinusitis with Nasal Polyposis

The recommended dose of DUPIXENT for adult patients is 300 mg given every other week.

Important Administration Instructions

DUPIXENT is intended for use under the guidance of a healthcare provider. A patient may self-inject DUPIXENT after training in subcutaneous injection technique using the pre-filled syringe or pre-filled pen. The DUPIXENT pre-filled pen is only for use in adults and adolescents aged 12 years and older. In adolescents 12 years of age and older, it is recommended that DUPIXENT be given by or under the supervision of an adult. DUPIXENT pre-filled syringe should be given by a caregiver in children 6-11 years of age. Provide proper training to patients and/or caregivers on the preparation and administration of DUPIXENT prior to use according to the "Instructions for Use".

For atopic dermatitis and asthma patients taking an initial 600 mg dose, administer each of the two DUPIXENT 300 mg injections at different injection sites.

For atopic dermatitis and asthma patients taking an initial 400 mg dose, administer each of the two DUPIXENT 200 mg injections at different injection sites.

Administer subcutaneous injection into the thigh or abdomen, except for the 2 inches (5 cm) around the navel. The upper arm can also be used if a caregiver administers the injection.

Rotate the injection site with each injection. DO NOT inject DUPIXENT into skin that is tender, damaged, bruised, or scarred.

If an every other week dose is missed, instruct the patient to administer the injection within 7 days from the missed dose and then resume the patient's original schedule. If the missed dose is not administered within 7 days, instruct the patient to wait until the next dose on the original schedule.

If an every 4 week dose is missed, instruct the patient to administer the injection within 7 days from the missed dose and then resume the patient's original schedule. If the missed dose is not administered within 7 days, instruct the patient to administer the dose, starting a new schedule based on this date.

The DUPIXENT "Instructions for Use" contains more detailed instructions on the preparation and administration of DUPIXENT [see Instructions for Use].

Preparation for Use of DUPIXENT

Before injection, remove DUPIXENT from the refrigerator and allow DUPIXENT to reach room temperature (45 minutes for the 300 mg/2 mL pre-filled syringe or pre-filled pen and 30 minutes for the 200 mg/1.14 mL pre-filled syringe) without removing the needle cap.

Inspect DUPIXENT visually for particulate matter and discoloration prior to administration. DUPIXENT is a clear to slightly opalescent, colorless to pale yellow solution. Do not use if the liquid contains visible particulate matter, is discolored or cloudy (other than clear to slightly opalescent, colorless to pale yellow). DUPIXENT does not contain preservatives; therefore, discard any unused product remaining in the pre-filled syringe or pre-filled pen.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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