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Dupixent Dosage

Generic name: Dupilumab 300mg in 2mL
Dosage form: injection, solution

Medically reviewed by Drugs.com. Last updated on Jun 26, 2019.

DUPIXENT is administered by subcutaneous injection.

Atopic Dermatitis

Dosing in Adults

The recommended dose of DUPIXENT for adult patients is an initial dose of 600 mg (two 300 mg injections), followed by 300 mg given every other week.

Dosing in Adolescents

The recommended dose of DUPIXENT for patients 12 to 17 years of age is specified in Table 1.

Table 1: Dose of DUPIXENT for Subcutaneous Administration in Adolescent Patients
Body Weight Initial Dose Subsequent Doses (every other week)
less than 60 kg 400 mg (two 200 mg injections) 200 mg
60 kg or more 600 mg (two 300 mg injections) 300 mg

Concomitant Topical Therapies

DUPIXENT can be used with or without topical corticosteroids. Topical calcineurin inhibitors may be used, but should be reserved for problem areas only, such as the face, neck, intertriginous and genital areas.

Asthma

The recommended dose of DUPIXENT for adults and adolescents (12 years of age and older) is:

  • an initial dose of 400 mg (two 200 mg injections) followed by 200 mg given every other week or
  • an initial dose of 600 mg (two 300 mg injections) followed by 300 mg given every other week
  • for patients with oral corticosteroids-dependent asthma, or with co-morbid moderate-to-severe atopic dermatitis for which DUPIXENT is indicated, start with an initial dose of 600 mg followed by 300 mg given every other week

Chronic Rhinosinusitis with Nasal Polyposis

The recommended dose of DUPIXENT for adult patients is 300 mg given every other week.

Important Administration Instructions

DUPIXENT is intended for use under the guidance of a healthcare provider. A patient may self-inject DUPIXENT after training in subcutaneous injection technique using the pre-filled syringe. Provide proper training to patients and/or caregivers on the preparation and administration of DUPIXENT prior to use according to the "Instructions for Use".

For atopic dermatitis and asthma patients taking an initial 600 mg dose, administer each of the two DUPIXENT 300 mg injections at different injection sites.

For asthma patients taking an initial 400 mg dose, administer each of the two DUPIXENT 200 mg injections at different injection sites.

Administer subcutaneous injection into the thigh or abdomen, except for the 2 inches (5 cm) around the navel. The upper arm can also be used if a caregiver administers the injection.

Rotate the injection site with each injection. DO NOT inject DUPIXENT into skin that is tender, damaged, bruised, or scarred.

If a dose is missed, instruct the patient to administer the injection within 7 days from the missed dose and then resume the patient's original schedule. If the missed dose is not administered within 7 days, instruct the patient to wait until the next dose on the original schedule.

The DUPIXENT "Instructions for Use" contains more detailed instructions on the preparation and administration of DUPIXENT [see Instructions for Use].

Preparation for Use of DUPIXENT Pre-filled Syringe with Needle Shield

Before injection, remove DUPIXENT pre-filled syringe from the refrigerator and allow DUPIXENT to reach room temperature (45 minutes for the 300 mg/2 mL pre-filled syringe and 30 minutes for the 200 mg/1.14 mL pre-filled syringe) without removing the needle cap.

Inspect DUPIXENT visually for particulate matter and discoloration prior to administration. DUPIXENT is a clear to slightly opalescent, colorless to pale yellow solution. Do not use if the liquid contains visible particulate matter, is discolored or cloudy (other than clear to slightly opalescent, colorless to pale yellow). DUPIXENT does not contain preservatives; therefore, discard any unused product remaining in the pre-filled syringe.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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