Skip to main content


Pronunciation: DU-pill-U-mab
Brand name: Dupixent
Dosage form: injection for subcutaneous use
Drug class: Interleukin inhibitors

Medically reviewed by Carmen Pope, BPharm. Last updated on Feb 8, 2024.

What is dupilumab?

Dupilumab (Dupixent) is a biologic that is given by subcutaneous (under the skin) injection that may be used to treat the following inflammatory conditions:

Dupilumab works by targeting and binding to a protein that is associated with inflammation called interleukin-4 (IL-4) receptor alpha subunit (IL-4Ra)], preventing IL-4 and IL-3 signaling. This inhibits the inflammatory response including the release of proinflammatory cytokines, chemokines, nitric oxide, and IgE. Dupilumab is an interleukin-4 receptor alpha antagonist.

Dupilumab was first FDA-approved on March 28, 2017.


Hypersensitivity reactions including anaphylaxis, serum sickness, angioedema, urticaria, rash, erythema nodosum, and erythema multiforme have been reported with Dupilumab. Do not use Dupilumab if you are allergic to dupilumab or any of the ingredients. Stop Dupilumab immediately and contact your healthcare provider if you develop any allergy symptoms.

May cause conjunctivitis and keratitis. Report new onset or worsening eye symptoms to your healthcare provider. Your healthcare provider may suggest an ophthalmological examination.

May increase the risk of developing eosinophilic conditions. Tell your doctor if you develop a red or purple rash, shortness of breath, or tingling or nerve pain in your hands or feet.

Your healthcare provider will decide if you need to continue with oral, topical, or inhaled corticosteroids while being treated with Dupilumab. These should be reduced gradually, do not discontinue without your doctor’s advice.

Report new onset or worsening joint pain or swelling to your healthcare provider. Further investigation may be required.

Any pre-existing worm or parasitic (helminth) infections should be treated before initiating Dupilumab. If patients become infected during treatment and do not respond to antihelminths, then discontinue dupilumab until the infection resolves.

Avoid the use of live vaccines. May reduce the immune response to other vaccinations.

It is not known if dupilumab is safe and effective for children with:

Before taking

Before using dupilumab tell your healthcare provider about all your medical conditions, including if you:


It is not known whether dupilumab will harm your unborn baby. There is a pregnancy exposure registry for women who use dupilumab during pregnancy. Your healthcare provider can enroll you in this registry or you can enroll yourself or get more information about the registry by calling 1-877-311-8972 or going to


It is not known whether dupilumab passes into breast milk.

How should I use dupilumab?

Use dupilumab exactly as prescribed by your doctor. Follow all directions on your dupilumab label and package insert.

Dupilumab is not a rescue medicine for asthma attacks. Use only fast-acting inhalation medicine for an attack. Seek medical attention if your breathing problems get worse quickly, or if you think your asthma medications are not working as well.

Dupilumab is injected under the skin, usually once every 2 to 4 weeks. Your first dose may be given in 2 injections.

This drug can be used with or without topical corticosteroids.

Topical calcineurin inhibitors may be used but should be reserved for problem areas only (e.g., face, neck, intertriginous, and genital areas).

What happens if I miss a dose?

If you miss your injection by 7 days or less, use the missed dose as soon as you remember and then start a new every-week dose schedule from the time you remember.

If your dose schedule is every other week and you miss a dose of dupilumab give the injection within 7 days from the missed dose, then continue with your original schedule. If the missed dose is not given within 7 days, wait until the next scheduled dose to give your injection.

If your dose schedule is every 4 weeks and you miss a dose of dupilumab, give the injection within 7 days from the missed dose, then continue with your original schedule. If the missed dose is not given within 7 days, start a new every 4-week dose schedule from the time you remember to take your injection.

Do not use two doses at one time.

What happens if I overdose?

If you inject too much dupilumab, call your healthcare provider or Poison Help line at 1-800-222-1222 or go to the nearest hospital emergency room right away.

What should I avoid while using dupilumab?

Do not receive a "live" vaccine while using dupilumab. The vaccine may not work as well during this time and may not fully protect you from disease. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

What are the side effects of dupilumab?

Get emergency medical help if you have signs of an allergic reaction to dupilumab: hives, rash, itching; fever, swollen glands, joint pain; feeling light-headed, difficulty breathing; swelling of your face, lips, tongue, or throat.

Dupilumab may cause serious side effects. Call your doctor at once if you have:

The most common side effects of dupilumab include:

The following additional side effects have been reported with dupilumab:

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all of the possible side effects of dupilumab. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

What other drugs will affect dupilumab?

Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you:

Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine or other asthma medicine to come back.

This list is not complete. Other drugs may interact with dupilumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.


Store refrigerated at 2°C to 8°C (36°F to 46°F) in the original carton to protect from light.

You may store a prefilled syringe or injection pen at cool room temperature for up to 14 days. Do not store above 25°C (77°F). Throw the medicine away if not used within 14 days. Do not put it back into the refrigerator.

Do not expose dupilumab to heat or direct sunlight. Do NOT freeze. Do NOT shake.


Active: dupilumab.

Inactive: L-arginine hydrochloride, L-histidine, polysorbate 80, sodium acetate, sucrose, and water for injection.

The pre-filled syringe is available as 300mg/2mL, 200mg/1.14mL, and 100mg/0.67mL.

The pre-filled pen is available as 300mg/2mL, and 200mg/1.14 mL.


Sanofi-aventis U.S. LLC and Regeneron Pharmaceuticals Inc.

Popular FAQ

Dupixent can start to work in 2 to 4 weeks to relieve your symptoms of moderate-to-severe eczema, asthma, or chronic rhinosinusitis with nasal polyps. In studies of eosinophilic esophagitis, improved inflammation, swallowing or other symptoms was seen in at 24 weeks In patients 12 years and older and at 16 weeks in 1 to 11 years olds. For adults with prurigo nodularis, improved itching was seen at 12 and 24 weeks, and reduced skin lesions (clear or almost clear skin) at 24 weeks. Continue reading

Dupixent is approved by the FDA for five different uses, for use in: eczema (atopic dermatitis), asthma, nasal polyps (growths on the sinuses) accompanied by chronic rhinosinusitis (sinus and nasal cavity swelling), eosinophilic esophagitis (EoE), and prurigo nodularis. Dupixent works by lowering inflammation (swelling) that can lead to symptoms of these conditions. Continue reading

Dupixent (generic name: dupilumab) is given as a subcutaneous (under the skin) injection into the upper thigh or stomach area by the patient or a caregiver. Your doctor will tell you how often to inject Dupixent. Continue reading

More FAQ

View more FAQ

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.