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Dupilumab Side Effects

For the Consumer

Applies to dupilumab: subcutaneous solution

Along with its needed effects, dupilumab may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking dupilumab:

More common
  • Blistering or crusting of the skin
  • itchiness, redness of the eyes
  • excessive tearing
  • painful cold sores or blisters on the lips, nose, eyes, or genitals
  • reddening of the skin
  • scaly patches on the skin
  • sores or white patches on the lips, mouth, or throat
Less common
  • Burning or dry eyes
  • fever
  • pain, swelling of the eye or eyelid

Some side effects of dupilumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

For Healthcare Professionals

Applies to dupilumab: subcutaneous solution

Ocular

Very common (10% or more): Conjunctivitis (cluster includes conjunctivitis, allergic conjunctivitis, bacterial conjunctivitis, viral conjunctivitis, giant papillary conjunctivitis, eye irritation, and eye inflammation) (10%)
Common (1% to 10%): Blepharitis, eye pruritus, keratitis (cluster includes keratitis, ulcerative keratitis, allergic keratitis, atopic keratoconjunctivitis, and ophthalmic herpes simplex), dry eye[Ref]

Local

Very common (10% or more): Injection site reactions (10%)[Ref]

Immunologic

Common (1% to 10%): Herpes simplex viral infections (e.g., herpes simplex, genital herpes, herpes simplex otitis externa, herpes virus infection), immunogenicity[Ref]

Hypersensitivity

Uncommon (0.1% to 1%): Hypersensitivity[Ref]

Gastrointestinal

Common (1% to 10%): Oral herpes[Ref]

References

1. "Product Information. Dupixent (dupilumab)." sanofi-aventis, Bridgewater, NJ.

Some side effects of dupilumab may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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