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Dupilumab Dosage

Medically reviewed on May 19, 2017.

Applies to the following strengths: 300 mg/2 mL

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Dermatitis

Initial dose: 600 mg subcutaneously (two 300 mg injections) initially
Maintenance dose: 300 mg subcutaneously every other week

Comments:
-This drug can be used with or without topical corticosteroids.
-Topical calcineurin inhibitors may be used, but should be reserved for problem areas only (i.e., face, neck, intertriginous and genital areas).
-If a dose is missed, it should be administered within 7 days from the missed dose and then resume the original schedule. If the missed dose is not administered within 7 days, it should be skipped until the next dose on the original schedule.

Use: For moderate-to-severe atopic dermatitis not adequately controlled with topical prescription therapies or when those therapies are not advisable

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-This drug is supplied as a prefilled syringe with or without a needle shield; refer to the manufacturer instructions for use.
-The patient may self-inject this drug after training in subcutaneous injection technique using the prefilled syringe.
-Administer the injections into the thigh or abdomen, except for the 2 inches (5 cm) around the navel; the upper arm can also be used if a caregiver administers the injection.
-Do not inject into skin that is tender, damaged, bruised, or scarred.
-Rotate the injection site with each injection.
-For the initial 600 mg dose, administer each of the two 300 mg injections at different injection sites.
-Do not inject into skin that is tender, damaged, bruised, or scarred.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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