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Dupilumab Dosage

Medically reviewed by Drugs.com. Last updated on Sep 21, 2020.

Applies to the following strengths: 300 mg/2 mL; 200 mg/1.14 mL

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Atopic Dermatitis

Initial dose: 600 mg subcutaneously (two 300 mg injections in different sites)
Maintenance dose: 300 mg subcutaneously every other week

Comments:
-This drug can be used with or without topical corticosteroids.
-Topical calcineurin inhibitors may be used but should be reserved for problem areas only (i.e., face, neck, intertriginous and genital areas).
-If a dose is missed, administer within 7 days then resume the original schedule; if administered within 7 days, it should be skipped until the next dose.

Use: For moderate-to-severe atopic dermatitis not adequately controlled with topical prescription therapies or when those therapies are not advisable

Usual Adult Dose for Asthma

400 mg subcutaneously (two 200 mg injections) initially, followed by 300 mg subcutaneously every other week
OR
600 mg subcutaneously (two 300 mg injections) initially, followed by 300 mg subcutaneously every other week

For patients requiring concomitant oral corticosteroids or with comorbid moderate-to-severe atopic dermatitis, start with an initial dose of 600 mg subcutaneously followed by 300 mg subcutaneously every other week.

Use: As add-on maintenance treatment in patients with moderate-to-severe asthma with an eosinophilic phenotype or with oral corticosteroid dependent asthma

Usual Pediatric Dose for Atopic Dermatitis

12 years and older:
Less than 60 kg:
-Initial dose: 400 mg subcutaneously (two 200 mg injections in different sites)
-Maintenance dose: 200 mg subcutaneously every other week
60 kg or greater:
-Initial dose: 600 mg subcutaneously (two 300 mg injections in different sites)
-Maintenance dose: 300 mg subcutaneously every other week

Comments:
-This drug can be used with or without topical corticosteroids.
-Topical calcineurin inhibitors may be used but should be reserved for problem areas only (i.e., face, neck, intertriginous and genital areas).
-If a dose is missed, administer within 7 days then resume the original schedule; if administered within 7 days, it should be skipped until the next dose.

Use: For patients 12 years and older with moderate-to-severe atopic dermatitis not adequately controlled with topical prescription therapies or when those therapies are not advisable

Usual Pediatric Dose for Asthma

12 years and older:
400 mg subcutaneously (two 200 mg injections) initially, followed by 300 mg subcutaneously every other week
OR
600 mg subcutaneously (two 300 mg injections) initially, followed by 300 mg subcutaneously every other week

For patients requiring concomitant oral corticosteroids or with comorbid moderate-to-severe atopic dermatitis, start with an initial dose of 600 mg subcutaneously followed by 300 mg subcutaneously every other week.

Use: As add-on maintenance treatment in patients with moderate-to-severe asthma with an eosinophilic phenotype or with oral corticosteroid dependent asthma

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS:
-Hypersensitivity to the active component or any of the ingredients

Safety and efficacy have not been established in patients younger than 12 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-This drug is supplied as a prefilled syringe with or without a needle shield; refer to the manufacturer instructions for use for more information.
-The patient may self-inject this drug after training in subcutaneous injection technique using the prefilled syringe.
-Administer the injections into the thigh or abdomen, except for the 2 inches (5 cm) around the navel; the upper arm can also be used if a caregiver administers the injection.
-Do not inject into skin that is tender, damaged, bruised, or scarred.
-Rotate the injection site with each injection.
-For the initial 400 mg dose, administer each of the two 200 mg injections at different injection sites.
-For the initial 600 mg dose, administer each of the two 300 mg injections at different injection sites.
-If a dose is missed, administer it within 7 days from the missed dose and then resume the original schedule. If the missed dose is not administered within 7 days, wait until the next dose on the original schedule.

Storage requirements:
-Store refrigerated at 36F to 46F (2C to 8C) in the original carton to protect from light.
-Prefilled syringes may be kept at room temperature up to 77F (25C) for a maximum of 14 days. Do not store above 77F (25C).
-After removal from the refrigerator, this drug should be used within 14 days or discarded.
-Do not expose the prefilled syringe to heat or direct sunlight.
-Do not freeze. do not shake.

Reconstitution/preparation techniques:
-Before injection, remove the prefilled syringe from the refrigerator and allow to reach room temperature (45 minutes for the 300 mg/2 mL prefilled syringe and 30 minutes for the 200 mg/1.14 mL prefilled syringe) without removing the needle cap.
-Inspect visually for particulate matter and discoloration prior to administration. This drug is a clear to slightly opalescent, colorless to pale yellow solution. Do not use if the liquid contains visible particulate matter, is discolored or cloudy (other than clear to slightly opalescent, colorless to pale yellow).

General:
-This drug is sterile and preservative-free. Discard any unused portion.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Frequently Asked Questions