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Dupilumab Dosage

Medically reviewed by Drugs.com. Last updated on Mar 25, 2024.

Applies to the following strengths: 100 mg/0.67 mL; 300 mg/2 mL; 200 mg/1.14 mL

Usual Adult Dose for Atopic Dermatitis

Initial dose: 600 mg subcutaneously once
Subsequent doses: 300 mg subcutaneously every other week

Comments:


Use: For the treatment of patients with moderate to severe atopic dermatitis whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable

Usual Adult Dose for Sinusitis

300 mg subcutaneously every other week

Use: As an add-on maintenance treatment in patients with inadequately controlled chronic rhinosinusitis with nasal polyposis (CRSwNP)

Usual Adult Dose for Asthma

Initial loading dose: 400 mg subcutaneously once
Subsequent doses: 200 mg subcutaneously every 2 weeks
OR
Initial loading dose: 600 mg subcutaneously once
Subsequent doses: 300 mg subcutaneously every 2 weeks

For patients with oral corticosteroid-dependent asthma, with comorbid moderate to severe atopic dermatitis, or with comorbid CRSwNP:


Comments:

Use: As an add-on maintenance treatment of patients with moderate to severe asthma characterized by an eosinophilic phenotype or with oral corticosteroid-dependent asthma

Usual Adult Dose for Eosinophilic Esophagitis

At least 40 kg: 300 mg subcutaneously every week

Use: For the treatment of patients with eosinophilic esophagitis

Usual Adult Dose for Prurigo Nodularis

Initial dose: 600 mg subcutaneously once
Subsequent doses: 300 mg subcutaneously every other week

Comments:


Use: For the treatment of patients with prurigo nodularis

Usual Pediatric Dose for Atopic Dermatitis

6 months to 5 years:


6 to 17 years:

Comments:

Use: For the treatment of patients with moderate to severe atopic dermatitis whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable

Usual Pediatric Dose for Asthma

6 to 11 years:


For patients 6 to 11 years with comorbid moderate to severe atopic dermatitis:

12 years and older:
OR

For patients 12 years and older with oral corticosteroid-dependent asthma or with comorbid moderate to severe atopic dermatitis:

Comments:

Use: As an add-on maintenance treatment of patients with moderate to severe asthma characterized by an eosinophilic phenotype or with oral corticosteroid-dependent asthma

Usual Pediatric Dose for Eosinophilic Esophagitis

1 year and older:


Use: For the treatment of patients with eosinophilic esophagitis

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS:


Safety and efficacy have not been established in patients younger than 6 months with atopic dermatitis, younger than 6 years with asthma, or younger than 1 year or weighing less than 15 kg with eosinophilic esophagitis. Safety and efficacy have not been established in patients younger than 18 years with CRSwNP or prurigo nodularis.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:


Storage requirements:

Reconstitution/preparation techniques:

General:

Patient advice:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.