Dupixent Side Effects

Generic Name: dupilumab

Note: This document contains side effect information about dupilumab. Some of the dosage forms listed on this page may not apply to the brand name Dupixent.

In Summary

Common side effects of Dupixent include: allergic conjunctivitis, conjunctivitis, injection site reaction, ophthalmic inflammation, and eye irritation. Other side effects include: oral herpes simplex infection. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to dupilumab: subcutaneous solution

Along with its needed effects, dupilumab (the active ingredient contained in Dupixent) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking dupilumab:

• Blistering or crusting of the skin
• itchiness, redness of the eyes
• excessive tearing
• painful cold sores or blisters on the lips, nose, eyes, or genitals
• reddening of the skin
• scaly patches on the skin
• sores or white patches on the lips, mouth, or throat

• Burning or dry eyes
• fever
• pain, swelling of the eye or eyelid

Some side effects of dupilumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

For Healthcare Professionals

Applies to dupilumab: subcutaneous solution

Ocular

Very common (10% or more): Conjunctivitis (cluster includes conjunctivitis, allergic conjunctivitis, bacterial conjunctivitis, viral conjunctivitis, giant papillary conjunctivitis, eye irritation, and eye inflammation) (10%)
Common (1% to 10%): Blepharitis, eye pruritus, keratitis (e.g., keratitis, ulcerative keratitis, allergic keratitis, atopic keratoconjunctivitis, ophthalmic herpes simplex), dry eye^[Ref]

Local

Very common (10% or more): Injection site reactions (10%)^[Ref]

Immunologic

Common (1% to 10%): Herpes simplex viral infections (e.g., herpes simplex, genital herpes, herpes simplex otitis externa, herpes virus infection), immunogenicity
Very rare (less than 0.01%): Serum sickness/serum sickness-like reactions^[Ref]

Hypersensitivity

Uncommon (0.1% to 1%): Hypersensitivity^[Ref]

Gastrointestinal

Common (1% to 10%): Oral herpes^[Ref]

Hematologic

Common (1% to 10%): Eosinophilia^[Ref]

Nervous system

Common (1% to 10%): Headache^[Ref]

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer