Dupixent Pre-filled Syringe
Generic name: dupilumab [ doo-PIL-ue-mab ]
Other brand names of dupilumab include: Dupixent Pre-filled Pen, Dupixent Pre-filled Syringe
Drug class: Interleukin inhibitors
What is Dupixent Pre-filled Syringe?
Dupixent Pre-filled Syringe is used alone or with topical steroids to treat moderate-to-severe eczema (atopic dermatitis) in adults and children at least 6 months old. This medicine is used when other topical treatments did not work or stopped working.
Dupixent Pre-filled Syringe is also used with other medications for the maintenance treatment of moderate-to-severe asthma in adults and children at least 6 years old.
Dupixent Pre-filled Syringe is also used in adults with other medicines for the maintenance treatment of chronic obstructive pulmonary disease (COPD) that is not controlled by other medicines.
Dupixent Pre-filled Syringe is not a rescue medicine for treating breathing problems that get worse quickly.
Dupixent Pre-filled Syringe is also used with other medicines for the maintenance treatment of chronic rhinosinusitis with nasal polyposis (long term sinus inflammation) that is not controlled by other medicines in adults and children at least 12 years old.
Dupixent Pre-filled Syringe is also used to treat eosinophilic esophagitis in adults and children at least 1 year old who weigh at least 33 pounds (15 kilograms).
Dupixent Pre-filled Syringe is also used to treat prurigo nodularis in adults.
Dupixent Pre-filled Syringe is also used to treat chronic spontaneous urticaria that is not controlled by allergy medicine in adults and children at least 12 years old.
The prefilled pen is for use in adults and children at least 2 years old. The prefilled syringe is for use in adults and children at least 6 months old.
Dupixent Pre-filled Syringe may also be used for purposes not listed in this medication guide.
Dupixent Pre-filled Syringe side effects
Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.
Dupixent Pre-filled Syringe may cause serious side effects. Call your doctor at once if you have:
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new or worsening breathing problems;
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fast pulse, swollen glands, itching, nausea or vomiting, stomach cramps;
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eye pain, or changes in your vision such as blurred vision;
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new or worsening joint symptoms--joint pain, trouble walking, loss of balance or coordination;
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blood vessel inflammation--fever, headache, new or worsening cough, numbness, trouble breathing, night sweats, stomach pain, weight loss, skin rash, severe tingling, body or chest pain, feeling weak or tired; or
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psoriasis symptoms--itchy or scaly skin rash.
Common side effects of Dupixent Pre-filled Syringe may include:
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pain, bruising, swelling, or irritation where the medicine was injected;
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high count of a certain type of white blood cells (eosinophilia);
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redness, swelling, or irritation of your eyes or eyelids, blurred vision;
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stomach pain, nausea, vomiting, diarrhea;
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dry eyes;
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dizziness, sleep problems (insomnia), headache;
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cold symptoms such as runny or stuffy nose, sneezing, sore throat;
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joint or muscle pain, back pain;
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cold sores in or around your mouth and lips;
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skin sores or blisters, itching, tingling, burning pain in your thigh or lower back; or
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pain and burning when you urinate.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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Warnings
Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.
Before taking this medicine
You should not use Dupixent Pre-filled Syringe if you are allergic to it.
Tell your doctor if you have or have ever had:
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eye problems;
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infection caused by helminthic parasites; or
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if you are scheduled to receive a vaccine.
While you are using Dupixent Pre-filled Syringe, you may also have an increased risk of becoming infected with parasites (helminths). Talk with your doctor about what to look out for and how to treat this condition.
Make sure you are current on all vaccines before you start using Dupixent Pre-filled Syringe.
Do not allow a young child to use Dupixent Pre-filled Syringe without help from an adult.
It is not known if Dupixent Pre-filled Syringe will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
If you are pregnant, your name may be listed on a pregnancy registry to track the effects of dupilumab on the baby.
Ask a doctor if it is safe to breastfeed while using Dupixent Pre-filled Syringe.
How should I use Dupixent Pre-filled Syringe?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Dupixent Pre-filled Syringe is injected under the skin in the stomach, thigh, or upper arm. Your doctor will determine your treatment schedule.
A healthcare provider may teach you how to properly use the medication by yourself. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.
Prepare an injection only when you are ready to give it. Leave the needle cap on until you are ready to inject your dose. Call your pharmacist if the medicine looks cloudy, has changed colors or has particles in it.
Do not inject within 2 inches of your navel (belly button), or areas where the skin is hard, tender, bruised, or has scars. Do not inject into the same place two times in a row.
Doses are based on weight. Your dose may change if you gain or lose weight.
Throw away a prefilled syringe or pen after one use, even if there is still medicine left inside. Do not reuse a needle, syringe or pen. Place them in a puncture-proof "sharps" container and dispose of it following state or local laws. Keep out of the reach of children and pets.
If you also use a steroid medication, you should not stop using it suddenly. Follow your doctor's instructions about tapering your dose.
You may need frequent vision exams.
Store this medicine in the original container in the refrigerator. Protect from light and do not freeze or shake the medicine.
Take the medicine out of the refrigerator and let it reach room temperature for 30 to 45 minutes before injecting your dose. Do not heat a syringe or pen with hot water, sunlight, or a microwave.
You may store this medicine at room temperature for up to 14 days. Throw the medicine away if not used within 14 days. Do not put it back into the refrigerator.
What happens if I miss a dose?
For a once a week schedule: use the missed dose as soon as you can and start a new weekly schedule on the day you remember to use it.
If you use Dupixent Pre-filled Syringe every other week: use the medicine as soon as you remember and stay on your original schedule, but skip the missed dose and use your next dose at the regular time if you are 7 days late or more for the dose.
If you use Dupixent Pre-filled Syringe every 4 weeks: use the medicine as soon as you remember and stay on your original schedule, but start a new every 4 week schedule on the day you remember if you are 7 days late or more for the dose.
Do not use two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while using Dupixent Pre-filled Syringe?
Avoid receiving a "live" vaccine while you are being treated or right before starting treatment with Dupixent Pre-filled Syringe. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), and zoster (shingles).
What other drugs will affect Dupixent Pre-filled Syringe?
Tell your doctor about all your other medicines, especially:
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an oral, inhaled, or topical steroid medicine; or
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any medicine to treat asthma.
This list is not complete. Other drugs may affect Dupixent Pre-filled Syringe, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Biological Products Related to Dupixent
Find detailed information on biosimilars for this medication.
Popular FAQ
Why do Dupixent injections hurt so much?
Dupixent (dupilumab) injections can cause discomfort for some people. The amount of discomfort people feel from injections can depend on many factors, including the temperature of the medication and individual pain tolerance. However, there are some things you can do to reduce pain and discomfort from your Dupixent injection. Continue reading
How fast does Dupixent work?
Dupixent (generic name: dupilumab) can start to work in 2 to 4 weeks to relieve symptoms associated with inflammatory conditions like eczema, asthma, and sinus swelling due to nasal polyps. Initial improvements in some patients were seen at 12 weeks for chronic obstructive pulmonary disease (COPD), prurigo nodularis, and chronic spontaneous urticaria (CSU), and at 24 weeks for eosinophilic esophagitis.
Continue readingWhy does Dupixent cause eye problems?
Dupixent is associated with several different eye problems, including conjunctivitis, blepharitis, dry eyes, itchy eyes, and keratitis. The cause of the eye problems is thought to be due to Dupixent blocking interleukin-13 (IL-13), an inflammatory protein that also stimulates the production of goblet cells. Goblet cells are responsible for creating mucus in the eye and ensuring the stability of tears. So when Dupixent blocks IL-13 it also lowers the numbers of epithelial goblet cells leading to eye inflammation and eye problems. Continue reading
How does the Dupixent Myway copay card work?
With a Dupixent MyWay copay card, you may pay as little as $0 for out-of-pocket costs if you have commercial insurance. The maximum benefit per year is $13,000. Continue reading
Does Dupixent cause weight gain?
Yes, it does appear that Dupixent can cause weight gain, although this is not listed as a side effect in the product information. A case series of 12 people prescribed Dupixent reported an average weight gain of 6.1kg over one year – the amount of weight gained ranged from 0.1kg to 18.0kg. Anecdotally, blog sites also report weight gain as a side effect. How Dupixent causes weight gain is not known; however, people should be informed that weight gain may be a possible side effect of Dupixent. Continue reading
Is Dupixent an immunosuppressant?
No, Dupixent (dupilumab) is not an immunosuppressant or a steroid. Dupixent works by targeting a type of protein called an interleukin, that is involved in inflammation. Dupixent calms an overreactive immune system but does not suppress the immune system. This leads to fewer and less severe episodes of inflammation when used to treat conditions such as eczema, asthma, COPD, rhinosinusitis, esophagitis, chronic urticaria, and prurigo nodularis.
Continue readingWhy do insurance companies deny Dupixent?
There are a few different reasons why insurance companies deny Dupixent (dupilumab) coverage. Patients might run into insurance coverage challenges ranging from formulary exclusions and prior authorization hurdles to stringent step therapy requirements. Continue reading
How long can Dupixent stay out of the fridge?
Dupixent can stay out of the fridge for a maximum of 14 days at room temperature (up to 77°F [25°C]). If you do not use it within 14 days, then it must be thrown away. Do not expose Dupixent to temperatures above 77°F and do not put it back in the refrigerator if it has been inadvertently left out and allowed to warm up to room temperature. Continue reading
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