Medically reviewed on March 27, 2018
What is Inflectra?
Inflectra reduces the effects of a substance in the body that can cause inflammation.
Inflectra is used to treat rheumatoid arthritis, psoriatic arthritis, ulcerative colitis, Crohn's disease, and ankylosing spondylitis. This medicine is also used to treat severe or disabling plaque psoriasis.
Inflectra is often used when other medicines have not been effective.
Inflectra may also be used for purposes not listed in this medication guide.
Using Inflectra may increase your risk of developing certain types of cancer, including a rare fast-growing type of lymphoma that can be fatal. Ask your doctor about your specific risk.
Inflectra affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, tiredness, flu symptoms, cough, or skin pain.
Before taking this medicine
You should not be treated with Inflectra if you are allergic to it.
Tell your doctor if you have ever had tuberculosis, if anyone in your household has tuberculosis, or if you have recently traveled to an area where certain infections are common (Ohio River Valley, Mississippi River Valley, and the Southwest).
Tell your doctor if you have ever had:
severe heart failure, or other heart problems;
an active or recent infection, fever, cough, flu symptoms, open sores or skin wounds;
a weak immune system;
numbness or tingling anywhere in your body;
a disease that affects the nerves or muscles, such as multiple sclerosis or Guillain-Barré syndrome;
vaccination with BCG (Bacille Calmette-Guérin); or
if you are scheduled to receive any vaccines.
Make sure your child is current on all vaccines before he or she starts treatment with Inflectra.
Inflectra may cause a rare type of lymphoma (cancer) of the liver, spleen, and bone marrow that can be fatal. This has occurred mainly in teenagers and young men with Crohn's disease or ulcerative colitis. However, anyone with an inflammatory autoimmune disorder may have a higher risk of lymphoma. Talk with your doctor about your own risk.
Inflectra may cause other types of cancer, such as skin cancer or cancer of the cervix. Ask your doctor about this risk.
If you use Inflectra while you are pregnant, make sure any doctor caring for your new baby knows that you used the medicine during pregnancy. Being exposed to this medicine in the womb could affect your baby's vaccination schedule during the first 6 months of life.
You should not breast-feed while you are receiving Inflectra.
Inflectra is not for use in children younger than 6 years old.
How is Inflectra given?
Before you start treatment with Inflectra, your doctor may perform tests to make sure you do not have tuberculosis or other infections.
Inflectra is given as an infusion into a vein. A healthcare provider will give you this injection.
You may be watched closely after receiving Inflectra, to make sure the medicine has not caused any serious side effects.
Inflectra affects your immune system. You may get infections more easily, even serious or fatal infections. Your doctor will need to examine you on a regular basis, and you may need frequent TB tests.
If you need surgery, tell the surgeon ahead of time that you are using Inflectra.
If you've ever had hepatitis B, using Inflectra can cause this virus to become active or get worse. You may need frequent liver function tests while using Inflectra and for several months after you stop.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your Inflectra.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while receiving Inflectra?
Avoid activities that may increase your risk of bleeding injury.
Do not receive a "live" vaccine while using Inflectra, or you could develop a serious infection. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), and zoster (shingles).
Inflectra side effects
Some side effects may occur during the injection. Tell your caregiver if you feel dizzy, nauseated, light-headed, itchy or tingly, short of breath, or have a headache, fever, chills, muscle or joint pain, pain or tightness in your throat, chest pain, or trouble swallowing during the injection. Infusion reactions may also occur within 1 or 2 hours after injection.
Serious and sometimes fatal infections may occur during treatment with Inflectra. Call your doctor right away if you have signs of infection such as: fever, extreme tiredness, flu symptoms, cough, or skin symptoms (pain, warmth, or redness).
Also call your doctor if you have:
skin changes, new growths on the skin;
pale skin, easy bruising or bleeding;
liver problems--stomach pain (upper right side), tiredness, dark urine, jaundice (yellowing of the skin or eyes);
lupus-like syndrome--joint pain or swelling, chest discomfort, feeling short of breath, skin rash on your cheeks or arms (worsens in sunlight);
nerve problems--numbness or tingling, problems with vision, or weak feeling in your arms or legs, seizure;
new or worsening psoriasis--skin redness or scaly patches, raised bumps filled with pus;
signs of heart failure--shortness of breath with swelling of your ankles or feet, rapid weight gain;
signs of tuberculosis--fever, cough, night sweats, loss of appetite, weight loss, feeling constantly tired.
Common side effects may include:
stuffy nose, sinus pain;
sore throat, cough, chest pain;
headache, feeling light-headed;
rash, itching; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Inflectra?
Tell your doctor about all your other medicines, especially:
phototherapy for psoriasis; or
any other medicines to treat Crohn's disease, ulcerative colitis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, or psoriasis.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Copyright 1996-2018 Cerner Multum, Inc. Version: 17.01.
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- Drug class: TNF alfa inhibitors