What is Inflectra?
Inflectra reduces the effects of a substance in the body that can cause inflammation.
Inflectra is used to treat rheumatoid arthritis, psoriatic arthritis, ulcerative colitis, Crohn's disease, and ankylosing spondylitis. This medicine is also used to treat severe or disabling plaque psoriasis.
Inflectra is often used when other medicines have not been effective.
Inflectra may also be used for purposes not listed in this medication guide.
Using Inflectra may increase your risk of developing certain types of cancer, including a rare fast-growing type of lymphoma that can be fatal. Ask your doctor about your specific risk.
Inflectra can lower blood cells that help your body fight infections. Serious and sometimes fatal infections may occur. Call your doctor right away if you have signs of infection such as fever, tiredness, flu symptoms, cough, or skin pain.
Before taking this medicine
You should not be treated with Inflectra if you are allergic to it.
Tell your doctor if you have ever had tuberculosis, if anyone in your household has tuberculosis, or if you have recently traveled to an area where certain infections are common (Ohio River Valley, Mississippi River Valley, and the Southwest).
To make sure Inflectra is safe for you, tell your doctor if you have:
severe heart failure, or other heart problems;
an active or recent infection, fever, cough, flu symptoms, open sores or skin wounds;
a history of seizures;
a history of cancer;
a weak immune system;
numbness or tingling anywhere in your body;
a disease that affects the nerves or muscles, such as multiple sclerosis or Guillain-Barré syndrome;
if you have recently been vaccinated with BCG (Bacille Calmette-Guérin); or
if you are scheduled to receive any vaccines.
Make sure your child is current on all vaccines before he or she starts treatment with Inflectra.
Some people using Inflectra have developed a rare fast-growing type of lymphoma (cancer). This condition affects the liver, spleen, and bone marrow, and it can be fatal. This has occurred mainly in male teenagers and young men using this medicine with other medicines to treat Crohn's disease or ulcerative colitis.
However, people with autoimmune disorders (including rheumatoid arthritis, Crohn's disease, ankylosing spondylitis, and psoriasis) may have a higher risk of lymphoma. Talk to your doctor about your individual risk.
Using Inflectra may increase your risk of developing other types of cancer, including skin cancer. Ask your doctor about your specific risk.
Tell your doctor if you are pregnant or plan to become pregnant. If you use Inflectra while you are pregnant, make sure any doctor caring for your new baby knows that you used the medicine during pregnancy. Being exposed to this medicine in the womb could affect your baby's vaccination schedule during the first 6 months of life.
It is not known whether Inflectra passes into breast milk. You should not breast-feed while you are receiving this medicine.
Inflectra is not for use in children younger than 6 years old.
How is infliximab given?
Before you start treatment with Inflectra, your doctor may perform tests to make sure you do not have tuberculosis (TB) or other infections.
Inflectra is injected into a vein through an IV. A healthcare provider will give you this injection. You may be watched closely after receiving this medicine, to make sure the medicine has not caused any serious side effects.
Inflectra can lower blood cells that help your body fight infections and help your blood to clot. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Your blood may need to be tested often, and you may need frequent TB tests.
If you need surgery, tell the surgeon ahead of time that you are using Inflectra.
If you have ever had hepatitis B, Inflectra can cause this condition to come back or get worse. You will need frequent blood tests to check your liver function during treatment and for several months after you stop using this medicine.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your Inflectra injection.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while receiving Inflectra?
Avoid activities that may increase your risk of bleeding injury.
Do not receive a "live" vaccine while using Inflectra, or you could develop a serious infection. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.
Inflectra side effects
Some side effects may occur during the injection. Tell your caregiver right away if you feel dizzy, nauseated, light-headed, itchy or tingly, swollen, short of breath, or have a headache, fever, chills, muscle or joint pain, pain or tightness in your throat, chest pain, or trouble swallowing during the injection. Infusion reactions may also occur within 1 or 2 hours after injection.
Serious and sometimes fatal infections may occur during treatment with Inflectra. Call your doctor right away if you have signs of infection such as: fever, extreme tiredness, flu symptoms, cough, or skin symptoms (pain, warmth, or redness).
Call your doctor at once if you have:
skin changes, new growths on the skin;
pale skin, easy bruising or bleeding;
liver problems--upper stomach pain, tiredness, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
lupus-like syndrome--joint pain or swelling, chest discomfort, feeling short of breath, skin rash on your cheeks or arms (worsens in sunlight);
nerve problems--numbness or tingling, problems with vision, or weak feeling in your arms or legs;
new or worsening psoriasis--skin redness or scaly patches, raised bumps filled with pus;
signs of heart failure--shortness of breath with swelling of your ankles or feet, rapid weight gain;
signs of tuberculosis--fever, cough, night sweats, loss of appetite, weight loss, feeling constantly tired.
Common side effects may include:
stuffy nose, sinus pain;
sore throat, cough
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Inflectra?
Tell your doctor about all your current medicines and any you start or stop using, especially:
phototherapy for psoriasis; or
any other medicines to treat Crohn's disease, ulcerative colitis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, or psoriasis.
This list is not complete. Other drugs may interact with infliximab, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
More about Inflectra (infliximab)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Español
- 0 Reviews – Add your own review/rating
- Drug class: TNF alfa inhibitors
Related treatment guides
Where can I get more information?
- Your pharmacist can provide more information about Inflectra.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 16.01.
Date modified: February 01, 2018
Last reviewed: April 27, 2017