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This is what really works for managing psoriasis.

Medications for Plaque Psoriasis

Other names: Psoriasis vulgaris

What is Plaque Psoriasis:  Plaque psoriasis (psoriasis vulgaris) is the most common form of psoriasis. It is characterized by raised, inflamed, red lesions covered by a silvery white scale. It is typically found on the elbows, knees, scalp and lower back.

Medications to treat Plaque Psoriasis

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Popularity
Otezla C N 125 reviews
5.0

Generic name: apremilast systemic

Drug class: antirheumatics

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Enbrel B N 9 reviews
7.0

Generic name: etanercept systemic

Drug class: antirheumatics, TNF alfa inhibitors

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Humira B N 14 reviews
6.0

Generic name: adalimumab systemic

Drug class: antirheumatics, TNF alfa inhibitors

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Taclonex C N 2 reviews
9.0

Generic name: betamethasone / calcipotriene topical

Drug class: topical antipsoriatics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
calcipotriene C N 1 review
8.0

Generic name: calcipotriene topical

Brand names:  Dovonex, Calcitrene, Sorilux

Drug class: topical antipsoriatics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
betamethasone C N 3 reviews
10

Generic name: betamethasone topical

Brand name:  Sernivo

Drug class: topical steroids

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Cosentyx B N 24 reviews
8.0

Generic name: secukinumab systemic

Drug class: interleukin inhibitors

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Dovonex C N 1 review
8.0

Generic name: calcipotriene topical

Drug class: topical antipsoriatics

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Taclonex Scalp C N 1 review
8.0

Generic name: betamethasone / calcipotriene topical

Drug class: topical antipsoriatics

For consumers: dosage, interactions, side effects

 
Taltz N 35 reviews
7.0

Generic name: ixekizumab systemic

Drug class: interleukin inhibitors

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
betamethasone / calcipotriene C N 5 reviews
7.0

Generic name: betamethasone / calcipotriene topical

Brand names:  Taclonex, Taclonex Scalp, Enstilar

Drug class: topical antipsoriatics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, Prescribing Information

 
methylprednisolone C N Add review
10

Generic name: methylprednisolone systemic

Drug class: glucocorticoids

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Calcitrene C N Add review Rate

Generic name: calcipotriene topical

Drug class: topical antipsoriatics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
etanercept B N 9 reviews
7.0

Generic name: etanercept systemic

Brand names:  Enbrel, Erelzi

Drug class: antirheumatics, TNF alfa inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

 
dexamethasone C N 1 review
3.0

Generic name: dexamethasone systemic

Drug class: glucocorticoids

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Enstilar C N 1 review
6.0

Generic name: betamethasone / calcipotriene topical

Drug class: topical antipsoriatics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Sorilux C N Add review Rate

Generic name: calcipotriene topical

Drug class: topical antipsoriatics

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
adalimumab B N 14 reviews
6.0

Generic name: adalimumab systemic

Brand names:  Humira, Amjevita

Drug class: antirheumatics, TNF alfa inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

 
apremilast C N 127 reviews
5.0

Generic name: apremilast systemic

Brand name:  Otezla

Drug class: antirheumatics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

 
secukinumab B N 26 reviews
8.0

Generic name: secukinumab systemic

Brand name:  Cosentyx

Drug class: interleukin inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

 
hydroxyurea Off Label D N Add review Rate

Generic name: hydroxyurea systemic

Drug class: antimetabolites

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
Sernivo C N Add review Rate

Generic name: betamethasone topical

Drug class: topical steroids

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Remicade B N Add review Rate

Generic name: infliximab systemic

Drug class: antirheumatics, TNF alfa inhibitors

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Amjevita B N Add review Rate

Generic name: adalimumab systemic

Drug class: antirheumatics, TNF alfa inhibitors

For consumers: dosage, interactions, side effects

 
Erelzi B N Add review Rate

Generic name: etanercept systemic

Drug class: antirheumatics, TNF alfa inhibitors

For consumers: dosage, interactions, side effects

 
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Legend

Off Label This medication may not be approved by the FDA for the treatment of this condition.
Prescription Only / Over the Counter
Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Pregnancy
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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