Ixekizumab Dosage
Medically reviewed by Drugs.com. Last updated on June 18, 2020.
Applies to the following strengths: 80 mg/mL
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Plaque Psoriasis
160 mg (two 80 mg injections) subcutaneously at Week 0, followed by 80 mg at Weeks 2, 4, 6, 8, 10, and 12, then 80 mg every 4 weeks
Use: For the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy
Usual Adult Dose for Psoriatic Arthritis
160 mg (two 80 mg injections) subcutaneously at Week 0, followed by 80 mg at every 4 weeks
Comments:
-For psoriatic arthritis patients with coexistent moderate-to-severe plaque psoriasis, use the dosing regimen for plaque psoriasis.
-This drug may be administered alone or in combination with a conventional disease-modifying antirheumatic drug (cDMARD) (e.g., methotrexate).
Use: For the treatment of adult patients with active psoriatic arthritis
Usual Adult Dose for Ankylosing Spondylitis
160 mg (two 80 mg injections) subcutaneously at Week 0, followed by 80 mg at every 4 weeks
Comments:
-cDMARDs (e.g., sulfasalazine), corticosteroids, non-steroidal anti-inflammatory drugs (NSAIDs), and/or analgesics may be used during therapy with this drug.
Use: For the treatment of adult patients with active ankylosing spondylitis
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Precautions
CONTRAINDICATIONS:
-Hypersensitivity to the active component or any of the ingredients
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Storage requirements:
-Protect from light until use.
-Store refrigerated at 2C to 8C (36F to 46F).
-Do not freeze.
-Do not use this drug if it has been frozen.
-Do not shake.
-Discard the single-dose autoinjector or syringe after use in a puncture-resistant container.
-Not made with natural rubber latex.
Reconstitution/preparation techniques:
Preparation for Use of Autoinjector and Prefilled Syringe:
-Before injection, remove autoinjector or prefilled syringe from the refrigerator and allow it to reach room temperature (30 minutes) without removing the needle cap.
-Inspect visually for particulate matter and discoloration prior to administration. The solution should be clear and colorless to slightly yellow.
-Do not use if the liquid contains visible particles, is discolored or cloudy (other than clear and colorless to slightly yellow).
-The product does not contain preservatives, therefore discard any unused product remaining in the autoinjector or prefilled syringe.
-Instruct patients using the autoinjector or prefilled syringe to inject the full amount (1 mL), which provides 80 mg of drug, according to the directions provided in the manufacturer product information.
General:
-There are 2 delivery systems (i.e., autoinjector and prefilled syringe). The instructions for use of each system contain more detailed instructions on the preparation and administration.
-This drug is intended for use under the guidance and supervision of a physician.
-Patients may self-inject after training in subcutaneous injection technique using the autoinjector or prefilled syringe.
-Administer each injection at a different anatomic location (such as upper arms, thighs or any quadrant of the abdomen) than the previous injection, and not into areas where the skin is tender, bruised, erythematous, indurated, or affected by psoriasis.
-Administration in the upper, outer arm may be performed by a caregiver or healthcare provider.
-If a dose is missed, administer the dose as soon as possible. Thereafter, resume dosing at the regular scheduled intervals.
Patient advice:
-Inform patients that this drug may lower the ability of their immune system to fight infections.
-Instruct patients of the importance of communicating any history of infections to the healthcare provider, and contacting their healthcare provider if they develop any symptoms of infection.
-Advise patients to seek immediate medical attention if they experience any symptoms of serious hypersensitivity reactions.
Frequently asked questions
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More about ixekizumab
- Side Effects
- During Pregnancy or Breastfeeding
- Drug Interactions
- En Español
- 130 Reviews
- Drug class: interleukin inhibitors
Consumer resources
- Other brands
- Taltz
Professional resources
Related treatment guides
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.